ID A0A0Q5DKH1_9BURK Unreviewed; 695 AA.
AC A0A0Q5DKH1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KQQ45083.1};
GN ORFNames=ASF61_20835 {ECO:0000313|EMBL:KQQ45083.1};
OS Duganella sp. Leaf126.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Duganella.
OX NCBI_TaxID=1736266 {ECO:0000313|EMBL:KQQ45083.1, ECO:0000313|Proteomes:UP000051032};
RN [1] {ECO:0000313|EMBL:KQQ45083.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf126 {ECO:0000313|EMBL:KQQ45083.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQQ45083.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf126 {ECO:0000313|EMBL:KQQ45083.1};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQQ45083.1}.
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DR EMBL; LMNW01000005; KQQ45083.1; -; Genomic_DNA.
DR RefSeq; WP_056152733.1; NZ_LMNW01000005.1.
DR AlphaFoldDB; A0A0Q5DKH1; -.
DR STRING; 1736266.ASF61_20835; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000051032; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 297..473
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 477..569
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 605..690
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 695 AA; 73502 MW; F694C9E50CA4246A CRC64;
MTAHYQVHGA VAVITLDNPP VNGMGLATRT AAVAGIERAL ADDAVRAIVI TGAGKAFSGG
ADIREFNSPK ALAEPTLHTL IATAESATKP VVAAIHTICM GGGLELSLGC HYRVALPGAK
IALPEVKLGL LPGAGGTQRL PRVLGLEPAL QMIVTGEPVL SEQLAQTPLF DRVFEPGADL
IASAIAFADS IADVRPLPKV RARAVTHPQA DAVLQHARAQ ALARAPGYPA PLECIATVGA
AVSMPFEQGM KFERERFMHL IQGTESKALR HAFFAERVAG KVPDVPADTA LRPLTSAAVV
GAGMMGVGIA INFLNAGMPV ALLETSQHAL DKGLASLRTL YDNAVAKGRL TPEQLAQRVA
LVRGTLDYAD LAQADIVVEA VFEDLAVKQA VFRALDAVAR PGAILATNTS TLDVDAIAAV
TGRPQDVLGL HFFSPAHVMK LLEIVRGRET AVDVIATALA LSKKLRKTGV VARVCDGFIG
NRMIEQYSRQ AGFLLEEGAL PAQVDAAAER FGFAMGPFRM ADLAGNDIGQ AIRQRRAVEK
PELAYSRTAD LLCAMGRLGQ KTGAGWYDYR PGQRTPHPNA EVDAMIVAHS AQLGLERREI
ADREIVERLV YALVNEGARI LEEGIALRAS DIDMVYLTGY GFPAYRGGPM FYADTVGLPA
VLAAMQRFAA GRHGDAWTPA PLLARLAAEG GRFNG
//
