ID A0A0Q5T8K4_9BACT Unreviewed; 887 AA.
AC A0A0Q5T8K4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=ASG33_14300 {ECO:0000313|EMBL:KQS31475.1};
OS Dyadobacter sp. Leaf189.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Dyadobacter.
OX NCBI_TaxID=1736295 {ECO:0000313|EMBL:KQS31475.1, ECO:0000313|Proteomes:UP000051810};
RN [1] {ECO:0000313|EMBL:KQS31475.1, ECO:0000313|Proteomes:UP000051810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf189 {ECO:0000313|EMBL:KQS31475.1,
RC ECO:0000313|Proteomes:UP000051810};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQS31475.1, ECO:0000313|Proteomes:UP000051810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf189 {ECO:0000313|EMBL:KQS31475.1,
RC ECO:0000313|Proteomes:UP000051810};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQS31475.1}.
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DR EMBL; LMPS01000004; KQS31475.1; -; Genomic_DNA.
DR RefSeq; WP_056286220.1; NZ_LMPS01000004.1.
DR AlphaFoldDB; A0A0Q5T8K4; -.
DR STRING; 1736295.ASG33_14300; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000051810; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000051810}.
FT DOMAIN 711..727
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 637..644
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 887 AA; 100444 MW; A1118B4D906EE37F CRC64;
MAKAHKETPL NKQYNQIKAK YPGALLLFRV GDFYETFGED AIRASKILGI VLTRRNNGGA
HEELAGFPHH SLDNYLPKLV RAGERVAICD QLEDPATAKG IVKRGVTELV TPGVSYNDNV
LDTRRNNYLA AVHCGDNNLY GIAFLDISTG EFMTSQGNAA YIDKMLQGFS PSEVLFCKKF
KQEFSQLFGG KYHTFQLEDW CFGFDYGYEQ LTSHFQTTTL KGYGIETLPL GIVAAGVILH
YLKETEHKEV AHIGRITRLE EEKYVWLDRF TVRNLELVYA QQEGGVPLIQ ILDHTVTPMG
ARLLRKWMVL PLKEKLPIEE RLNIVSHFLK HESVHESILQ NLKLIGDLER LISKVAVRRI
NPKELGQLKR SLNQIIPIKE SLYKLLEKEK KKAKKDEAGE VVLSSELEVL LKYADQLDPC
IELVNKIETE LREDAPVLSN LGRMIKKGVD AELDELHAIS YEGKDYLLQL QNREIERTGI
SSLKIAYNKV FGYYLEVTHA HQNKVPAEWI RKQTLVNAER YITPELKEYE EKIINAEDSI
AAIEYRIFSE LITAATEQVN VIQKNASIIS ALDVLSSFAT VARKNNYVKP VITEDNRLDI
RDGRHPVIEQ QLPVGESYVP NDLYLDDSSQ QIIIITGPNM AGKSALLRQT ALIVLMAQMG
CYVPAKSASV GLVDKIFTRV GASDNLSRGE STFMVEMTET ASILNNLSDR SLILMDEIGR
GTSTYDGVSI AWAITEYLHS QHDCRPKTLF ATHYHELNQL SEDFPRIKNF NVAVKEVDNK
VIFLRKLKPG GSAHSFGIHV AQIAGMPQPI VLRANEIMQH LEKEHMTQEH KKKIKEIPKN
NFQLSIFEPA DPKIEELKEK LSMIDVNTLS PIEALLKLNE FQKLVKK
//
