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Database: UniProt
Entry: A0A0Q6V7D9_9ACTN
LinkDB: A0A0Q6V7D9_9ACTN
Original site: A0A0Q6V7D9_9ACTN 
ID   A0A0Q6V7D9_9ACTN        Unreviewed;       487 AA.
AC   A0A0Q6V7D9;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ASC61_07015 {ECO:0000313|EMBL:KQV74772.1};
OS   Aeromicrobium sp. Root344.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Aeromicrobium.
OX   NCBI_TaxID=1736521 {ECO:0000313|EMBL:KQV74772.1, ECO:0000313|Proteomes:UP000051702};
RN   [1] {ECO:0000313|EMBL:KQV74772.1, ECO:0000313|Proteomes:UP000051702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root344 {ECO:0000313|EMBL:KQV74772.1,
RC   ECO:0000313|Proteomes:UP000051702};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQV74772.1, ECO:0000313|Proteomes:UP000051702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root344 {ECO:0000313|EMBL:KQV74772.1,
RC   ECO:0000313|Proteomes:UP000051702};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQV74772.1}.
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DR   EMBL; LMDH01000001; KQV74772.1; -; Genomic_DNA.
DR   RefSeq; WP_056210618.1; NZ_LMDH01000001.1.
DR   EnsemblBacteria; KQV74772; KQV74772; ASC61_07015.
DR   Proteomes; UP000051702; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051702};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051702}.
FT   DOMAIN      178    306       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      390    459       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     186    193       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   487 AA;  54929 MW;  1B4F10A788743956 CRC64;
     MNDGQETSPE EHLNRVWQGA VDTLSPGAKV WVYSAKPLTL HNNIMIVAVQ DDLTRAQLES
     RVRPALEHAI STTLQQETRL VVTIEPTLID THQSRQDDLS TNQPNVYGQD NDLDDEDDDD
     QDEFVPTWAE RKTTPPRIGS VAEARLNPRY LFENFVIGSS NRFAHAAAVA VAEAPGKAYN
     PLVIHGESGL GKTHLLHAIG HYVLNLYPSS RVRYVNSEEF TNDVINAIRE NRTAALKRKY
     REIDVLLVDD IQFLEGKEST QTEFFHTFNA LHNENKQIVM TSDRPPKNLT TLEDRLRNRF
     EWGLTTDVQP PDLETRIAIL RKKAANEKLT APADVLEFIA SKVQTNIREL EGALIRATAF
     ANLNGTTVDL QLAQIVLKDL IAEGEEPDIT VGMIMAQTAA YSEFSIDDLC STNRSRNLVL
     ARQIAMYLCR ELTDMSLPKI GQEFGNRDHT TVMHADRKIR KLMAEKHAVY NQVTELTARI
     KQQARQS
//
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