ID A0A0Q6VGZ9_9ACTN Unreviewed; 646 AA.
AC A0A0Q6VGZ9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:KQV74451.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:KQV74451.1};
GN ORFNames=ASC61_05230 {ECO:0000313|EMBL:KQV74451.1};
OS Aeromicrobium sp. Root344.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=1736521 {ECO:0000313|EMBL:KQV74451.1, ECO:0000313|Proteomes:UP000051702};
RN [1] {ECO:0000313|EMBL:KQV74451.1, ECO:0000313|Proteomes:UP000051702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root344 {ECO:0000313|EMBL:KQV74451.1,
RC ECO:0000313|Proteomes:UP000051702};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQV74451.1, ECO:0000313|Proteomes:UP000051702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root344 {ECO:0000313|EMBL:KQV74451.1,
RC ECO:0000313|Proteomes:UP000051702};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQV74451.1}.
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DR EMBL; LMDH01000001; KQV74451.1; -; Genomic_DNA.
DR RefSeq; WP_056210175.1; NZ_LMDH01000001.1.
DR AlphaFoldDB; A0A0Q6VGZ9; -.
DR STRING; 1736521.ASC61_05230; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000051702; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KQV74451.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000051702}.
FT DOMAIN 30..84
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 96..463
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 646 AA; 69962 MW; E370BB591D2A110C CRC64;
MTDILWSPPL DGASRLERFM QELDQPFADY DALWAWSVEQ PNDFWRAAWR HFDVPSDGDP
TSALADASMP GAVWFPDVRL NYAEAMLRLP GRGDDDVVVV AASQSRDDVR LTARELRDQV
GRARAGLQRA GVRTGDRVAA YAPNIPETLV LLLAAASLGA VFSSCAPEFG TQSVVDRWQQ
IEPTILLAVD GYRYGAKGVD RRAEVEAITG SLPSLRTVVW LPYLDAEAPA PGGAVTWAEL
TAETGPLEFV RLPFAAPLYV LFSSGTTGLP KPIVHGHGGI TLEHLKSLAF HHDLGPADRF
FWFSTTGWMM WNLLISGLAV GSTIVMFDGN PAHPDLGMLW QLAERLEMTY FGTSAPFLLQ
CRKEGLVPRE TADLSRLRGV GSTGAPLPAE GFRWVYDAVS ATAQLGSISG GTDVCSGFVG
AAPIVPVYAG EISCRMLGCA VEAYDDERRP VTGSLGELVI TQPMPSMPVG FWGDTDGSRY
RAAYFEDIPG VWRHGDWITI SERGTCVITG RSDATLNRGG VRLGTAEFYT VVEALPEVVD
SLVVHLEDDE GGAGQLLLFV VLAERLDLDE ALHQRIAIAL RTQLSPRHVP DAIRQVAALP
RTLSGKKLEV PVKKILQGAS IEDAAAKGAL TDPTSLDAFV TIRETL
//
