ID A0A0Q7APP6_9BURK Unreviewed; 307 AA.
AC A0A0Q7APP6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
DE Short=Ftr {ECO:0000256|HAMAP-Rule:MF_00579};
DE EC=2.3.1.101 {ECO:0000256|HAMAP-Rule:MF_00579};
DE AltName: Full=H4MPT formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
GN Name=ffsA {ECO:0000256|HAMAP-Rule:MF_00579};
GN ORFNames=ASC76_03350 {ECO:0000313|EMBL:KQW40475.1};
OS Rhizobacter sp. Root404.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Rhizobacter.
OX NCBI_TaxID=1736528 {ECO:0000313|EMBL:KQW40475.1, ECO:0000313|Proteomes:UP000051611};
RN [1] {ECO:0000313|EMBL:KQW40475.1, ECO:0000313|Proteomes:UP000051611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root404 {ECO:0000313|EMBL:KQW40475.1,
RC ECO:0000313|Proteomes:UP000051611};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQW40475.1, ECO:0000313|Proteomes:UP000051611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root404 {ECO:0000313|EMBL:KQW40475.1,
RC ECO:0000313|Proteomes:UP000051611};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the transfer of a formyl group from 5-formyl
CC tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to
CC produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin
CC (H(4)MPT). {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC EC=2.3.1.101; Evidence={ECO:0000256|HAMAP-Rule:MF_00579};
CC -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from
CC formaldehyde (H(4)MPT route): step 4/5. {ECO:0000256|HAMAP-
CC Rule:MF_00579}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SIMILARITY: Belongs to the FTR family. {ECO:0000256|ARBA:ARBA00006770,
CC ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQW40475.1}.
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DR EMBL; LMDS01000001; KQW40475.1; -; Genomic_DNA.
DR RefSeq; WP_056462308.1; NZ_LMDS01000001.1.
DR AlphaFoldDB; A0A0Q7APP6; -.
DR STRING; 1736528.ASC76_03350; -.
DR UniPathway; UPA00562; UER00704.
DR Proteomes; UP000051611; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046294; P:formaldehyde catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.520; -; 2.
DR HAMAP; MF_00579; FTR; 1.
DR InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR NCBIfam; TIGR03119; one_C_fhcD; 1.
DR Pfam; PF01913; FTR; 1.
DR Pfam; PF02741; FTR_C; 1.
DR PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR SUPFAM; SSF55112; Formylmethanofuran:tetrahydromethanopterin formyltransferase; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|HAMAP-Rule:MF_00579,
KW ECO:0000313|EMBL:KQW40475.1}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00579};
KW Reference proteome {ECO:0000313|Proteomes:UP000051611};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00579}.
FT DOMAIN 7..147
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01913"
FT DOMAIN 150..301
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02741"
SQ SEQUENCE 307 AA; 31811 MW; 1C715ED241D3D012 CRC64;
MSDARVLNGV AIDDTFAEAF PMKATRLVIT AHNPTWARHA AVSASGFATS VIACGCEAGI
ERELGPDETP DGRPGIALLI FSMSGKELAK QVERRVGQCV LTCPTTAVFA GVAEGEAIAL
GKNLRFFGDG WQISKVIEGI RYWRVPVMDG EFVAQETTAV TKAVGGGNLL MLATDTESAL
AAAEAAVVAM KRLPNVIMPF PGGVVRSGSK VGSKYAALSA STNDAFCPGL YGLAKKSELT
PEVHCVLEIV IDGLTEADVG AAMLAGVQSC IAIGSTGGML RVSAGNYGGK LGPYHFHLHK
LLDGAGS
//
