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Database: UniProt
Entry: A0A0Q7BGS0_9ACTN
LinkDB: A0A0Q7BGS0_9ACTN
Original site: A0A0Q7BGS0_9ACTN 
ID   A0A0Q7BGS0_9ACTN        Unreviewed;       484 AA.
AC   A0A0Q7BGS0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ASC77_14330 {ECO:0000313|EMBL:KQW48088.1};
OS   Nocardioides sp. Root1257.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=1736439 {ECO:0000313|EMBL:KQW48088.1, ECO:0000313|Proteomes:UP000051939};
RN   [1] {ECO:0000313|EMBL:KQW48088.1, ECO:0000313|Proteomes:UP000051939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root1257 {ECO:0000313|EMBL:KQW48088.1,
RC   ECO:0000313|Proteomes:UP000051939};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQW48088.1, ECO:0000313|Proteomes:UP000051939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root1257 {ECO:0000313|EMBL:KQW48088.1,
RC   ECO:0000313|Proteomes:UP000051939};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQW48088.1}.
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DR   EMBL; LMDV01000009; KQW48088.1; -; Genomic_DNA.
DR   RefSeq; WP_056156539.1; NZ_LMDV01000009.1.
DR   EnsemblBacteria; KQW48088; KQW48088; ASC77_14330.
DR   Proteomes; UP000051939; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051939};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051939}.
FT   DOMAIN      175    303       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      387    456       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     183    190       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   484 AA;  54350 MW;  CAEEF2E9923C3E56 CRC64;
     MKKAGAVEQH TSDLDVAWRG VVDDLQPNQR AWLSASEPVT LHESTAIVAV PNDFTRNQLE
     GRLRAQLEDA LSLRFGREIR IAVTVNPALE TEMTPATVEE LPETQSDLST NRQVDVAPTA
     SAPPPTPEPV DVGPRPTSLE TRLNPKYTFE TFVIGSSNRF PHAAAVAVAE APGKAYNPLL
     VYGDSGLGKT HLLHAIGHYV RSLYTSARVR YVSSEEFTNE FINAIRDDRQ DRFKRRYRDV
     DVLLIDDIQF LEGKTQTQEE FFHTFNTLHN ANKQIVLTSD RAPKRLEALE DRLRNRFEWG
     LITDVQPPDL ETRIAILRKK AAMDRLTAPP DVLEFIASKI QTNIRELEGA LIRVTAFANL
     NRQEVDMTLA EIVLKDLIPE GGEPEITAAL IIAQTAAYFG LSIEELTGPS RGRHLVMARQ
     IAMYLCRELT DLSLPKIGAQ FGNRDHTTVM YADRKINQLL AERRAVFNQV SELTNRIKLQ
     ARQS
//
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