ID A0A0Q7DYM5_9CAUL Unreviewed; 507 AA.
AC A0A0Q7DYM5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KQW82406.1};
GN ORFNames=ASC65_09155 {ECO:0000313|EMBL:KQW82406.1};
OS Brevundimonas sp. Root1279.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Brevundimonas.
OX NCBI_TaxID=1736443 {ECO:0000313|EMBL:KQW82406.1, ECO:0000313|Proteomes:UP000050923};
RN [1] {ECO:0000313|Proteomes:UP000050923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1279 {ECO:0000313|Proteomes:UP000050923};
RA Garrido-Oter R., Bai Y.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQW82406.1, ECO:0000313|Proteomes:UP000050923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1279 {ECO:0000313|EMBL:KQW82406.1,
RC ECO:0000313|Proteomes:UP000050923};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQW82406.1}.
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DR EMBL; LMEB01000006; KQW82406.1; -; Genomic_DNA.
DR RefSeq; WP_056451876.1; NZ_LMEB01000006.1.
DR AlphaFoldDB; A0A0Q7DYM5; -.
DR STRING; 1736443.ASC65_09155; -.
DR OrthoDB; 5695497at2; -.
DR Proteomes; UP000050923; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000050923};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 83
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 17..20
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 83
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 340
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 349
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 353
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 507 AA; 56087 MW; E9284CD5A098691A CRC64;
MDQGQARRIR SVVIVGGGTA GWMTAAALVQ HFRGAPVSIT VVESSEIGTI GVGEATIPTI
RRFYAQLGLR DAEVMQATQA TCKLGIRFQG WSGAGPDFIH PFGLFGQDLK GVGFHHYWLK
QRAASDPGPM GDYSLGASLA AAGKFTLPSP NPPSSLSVFD WALHFDAALF AQYLRRYAEA
GGCQRIDARI GSGALRPEDG FVRALVLDDG REVEGDLFVD CSGFRGLLIG EALGVPYEDW
GRWLRCDAAW AVQSENASSA NPDPFTRVTA RTAGWQWGIP LQHRAGNGVV FSSAHTSDED
ALAELSANLM GRPLMEPRRI GFRPGRRARA WEKNCVAIGL SAGFLEPLES TSIALIENGI
ERLKSLFPDR DFAGPVLDEF NDQSAREMER VRDFIVLHYK LNRRDEPFWR DCREGEIPET
LERKLALWKA RGQFVRYRWE MFHPASWLAI YAGFDVFPGD YDPAVDALDP AYLERSLKEM
RENLSRLVAE TPDHARFLAA LDPARAA
//
