ID A0A0Q7EAY1_9CAUL Unreviewed; 541 AA.
AC A0A0Q7EAY1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=ASC65_02545 {ECO:0000313|EMBL:KQW86780.1};
OS Brevundimonas sp. Root1279.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Brevundimonas.
OX NCBI_TaxID=1736443 {ECO:0000313|EMBL:KQW86780.1, ECO:0000313|Proteomes:UP000050923};
RN [1] {ECO:0000313|Proteomes:UP000050923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1279 {ECO:0000313|Proteomes:UP000050923};
RA Garrido-Oter R., Bai Y.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQW86780.1, ECO:0000313|Proteomes:UP000050923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1279 {ECO:0000313|EMBL:KQW86780.1,
RC ECO:0000313|Proteomes:UP000050923};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQW86780.1}.
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DR EMBL; LMEB01000001; KQW86780.1; -; Genomic_DNA.
DR RefSeq; WP_056449031.1; NZ_LMEB01000001.1.
DR AlphaFoldDB; A0A0Q7EAY1; -.
DR STRING; 1736443.ASC65_02545; -.
DR Proteomes; UP000050923; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProt.
DR CDD; cd03468; PolY_like; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000050923}.
FT DOMAIN 37..168
FT /note="UmuC"
FT /evidence="ECO:0000259|Pfam:PF00817"
FT DOMAIN 266..337
FT /note="DNA polymerase Y-family little finger"
FT /evidence="ECO:0000259|Pfam:PF11799"
FT REGION 408..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 59025 MW; 036C138CCE8772AE CRC64;
MRRIVSVWLI DWPISVRRRS LERARRPASP PEPALDPATP FALILKNSRG AAVLHALNPA
ARALGLKRDQ TQADALAMAP HLLCQPADPA ADARALEVLA AWAERWSPSV SVDPSGGGLE
GLFLDVTGAT HLFGGEAALL DQIRQRLATA GSRCRVALAP TPGAAWALAR WGEGAAPIAT
ENTLSADLAD LPVEALRIDD KTLAAARRFG LRTIGSLYAM PRAGLARRFR DGDAVGLVKR
LDQARGYVAE ALVPVRPPAH YRAWQAYAEP LGDLGGVEAR LPELAEDLAR ALERDGQGAR
ALTLTGFRTD GRTTRLPVRM GAPGREAKIW LRLFREAGLG RLELGFGLDA LMLTADLAEP
MTARQAALGD EAEAKQAESL AALVDRLSAR LGEDRVLVGE AVDSWTPERA ERLRPAQDAL
SGRRPAAAGD PDGRPRPVLL LDPPEPIQDP VFDLPEGAPA RFTWRRVSRR VVRAEGPERL
SPEWWRPRPD GRDVRTRDYY RVEDGEGGRY WLFREGLYGW DYAGPADKRP APSWWMHGVL
A
//
