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Database: UniProt
Entry: A0A0Q7JGA0_9ACTN
LinkDB: A0A0Q7JGA0_9ACTN
Original site: A0A0Q7JGA0_9ACTN 
ID   A0A0Q7JGA0_9ACTN        Unreviewed;       492 AA.
AC   A0A0Q7JGA0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-SEP-2017, entry version 16.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ASD06_15005 {ECO:0000313|EMBL:KQX62173.1};
OS   Angustibacter sp. Root456.
OC   Bacteria; Actinobacteria; Kineosporiales; Kineosporiaceae.
OX   NCBI_TaxID=1736539 {ECO:0000313|EMBL:KQX62173.1, ECO:0000313|Proteomes:UP000051170};
RN   [1] {ECO:0000313|EMBL:KQX62173.1, ECO:0000313|Proteomes:UP000051170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root456 {ECO:0000313|EMBL:KQX62173.1,
RC   ECO:0000313|Proteomes:UP000051170};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQX62173.1, ECO:0000313|Proteomes:UP000051170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root456 {ECO:0000313|EMBL:KQX62173.1,
RC   ECO:0000313|Proteomes:UP000051170};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQX62173.1}.
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DR   EMBL; LMER01000020; KQX62173.1; -; Genomic_DNA.
DR   EnsemblBacteria; KQX62173; KQX62173; ASD06_15005.
DR   Proteomes; UP000051170; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051170};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051170}.
FT   DOMAIN      185    313       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      397    466       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     193    200       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      459    486       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   492 AA;  54263 MW;  B6BDB4C1DEF3931D CRC64;
     MARVWQGTVA ALGDAGLNAQ QRAFLRLAKL VGLIDTTALV AVPNEYTKDV LEQRLRAQVV
     DALGAQLERE VLLAVTVDPS LAADQVGEIT VEHGSDSTHS PASTDADALP GPEALGNGYA
     TVDDDFDLDE PVAPRPALAT SGAAADEAAA SHLNPKYVFD SFVIGSSNRF AHAAAVAVAE
     APAKAYNPLF VYGESGLGKT HLLHAIGHYA RNLYPGVRVR YVNSEEFTND FINSIRDDKA
     QAFQRRHRDV DILLIDDIQF LQGKVQTQEE FFHTFNTLHN ANKQVVITSD LPPKQLSGFE
     ERMRSRFEWG LITDVQPPDL ETRIAILRKK AILERMTAPD EVMEYIASRI STNIRELEGA
     LIRVTAFASL NRQPVDLALA EIVLKDLIPS DGSPEITSAV IIGQTASYFG LTIDDLQGSS
     RSRVLVNARQ IAMYLCRELT DLSLPKIGQQ FGNRDHTTVM HAERKIRQLM AERRSIYNQV
     TELTNRIKQQ SR
//
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