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Database: UniProt
Entry: A0A0Q7K3P6_9ACTN
LinkDB: A0A0Q7K3P6_9ACTN
Original site: A0A0Q7K3P6_9ACTN 
ID   A0A0Q7K3P6_9ACTN        Unreviewed;       488 AA.
AC   A0A0Q7K3P6;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ASD10_02515 {ECO:0000313|EMBL:KQX74146.1};
OS   Aeromicrobium sp. Root472D3.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Aeromicrobium.
OX   NCBI_TaxID=1736540 {ECO:0000313|EMBL:KQX74146.1, ECO:0000313|Proteomes:UP000050971};
RN   [1] {ECO:0000313|EMBL:KQX74146.1, ECO:0000313|Proteomes:UP000050971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root472D3 {ECO:0000313|EMBL:KQX74146.1,
RC   ECO:0000313|Proteomes:UP000050971};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQX74146.1, ECO:0000313|Proteomes:UP000050971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root472D3 {ECO:0000313|EMBL:KQX74146.1,
RC   ECO:0000313|Proteomes:UP000050971};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQX74146.1}.
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DR   EMBL; LMET01000001; KQX74146.1; -; Genomic_DNA.
DR   RefSeq; WP_056604129.1; NZ_LMET01000001.1.
DR   EnsemblBacteria; KQX74146; KQX74146; ASD10_02515.
DR   Proteomes; UP000050971; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050971};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050971}.
FT   DOMAIN      179    307       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      391    460       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     187    194       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   488 AA;  54695 MW;  90C7469D3E0AF90E CRC64;
     MQDGQDASPD EHLNEVWQRA VATLSPGAKV WVYSAKPLTL HNNIMIVAVQ DDLTRAQLES
     RVRPALEHAI STTLQQETRL VVTIDPSLID SLHSQQDDLS INRQVGASTQ EQEPDDEDDD
     SGDEFVPSWA ERSSAPPRIG TVAEARLNPR YLFENFVIGS SNRFAHAAAV AVAEAPGKAY
     NPLVIHGESG LGKTHLLHAI GHYVLNLYPS SRVRYVNSEE FTNDVINAIR ENRTAALKRK
     YREIDVLLVD DIQFLEGKES TQTEFFHTFN ALHNENKQIV MTSDRPPKNL TTLEDRLRNR
     FEWGLTTDVQ PPDLETRIAI LRKKAANEKL TAPADVLEFI ASKVQTNIRE LEGALIRATA
     FANLNGTTVD LQLAQIVLKD LIAEGEEPDI TAGMIMAQTA AYSEFSIDDL CSTNRSRNLV
     LARQIAMYLC RELTDMSLPK IGQEFGNRDH TTVMHADRKI RKLMAEKHAV YNQVTELTAR
     IKQQARQS
//
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