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Database: UniProt
Entry: A0A0Q7U5N4_9MICO
LinkDB: A0A0Q7U5N4_9MICO
Original site: A0A0Q7U5N4_9MICO 
ID   A0A0Q7U5N4_9MICO        Unreviewed;       473 AA.
AC   A0A0Q7U5N4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   05-JUL-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ASD19_12045 {ECO:0000313|EMBL:KQZ07319.1};
OS   Microbacterium sp. Root53.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae;
OC   Microbacterium.
OX   NCBI_TaxID=1736553 {ECO:0000313|EMBL:KQZ07319.1, ECO:0000313|Proteomes:UP000051407};
RN   [1] {ECO:0000313|EMBL:KQZ07319.1, ECO:0000313|Proteomes:UP000051407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root53 {ECO:0000313|EMBL:KQZ07319.1,
RC   ECO:0000313|Proteomes:UP000051407};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQZ07319.1, ECO:0000313|Proteomes:UP000051407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root53 {ECO:0000313|EMBL:KQZ07319.1,
RC   ECO:0000313|Proteomes:UP000051407};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQZ07319.1}.
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DR   EMBL; LMFR01000006; KQZ07319.1; -; Genomic_DNA.
DR   RefSeq; WP_055988799.1; NZ_LMFR01000006.1.
DR   EnsemblBacteria; KQZ07319; KQZ07319; ASD19_12045.
DR   Proteomes; UP000051407; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051407};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051407}.
FT   DOMAIN      168    296       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      380    449       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     176    183       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   473 AA;  52680 MW;  61336BB4E4D54219 CRC64;
     MQDVPPGQRI PDVPVWRAVL VELEGDDRVT PQMKGFLSLV VPEGVMGGTL YLAVPNDLTA
     AQITKRLRDP IMEALARLGD DAQSFRVTVN PELSEAQFPP ALGSTTLGAP EPAQPQRPVA
     ENPTESQTPS RNDTRLNPKY TFDNFVIGQS NRFAHAAAVA VAEAPAKAYN PLFIYGDSGL
     GKTHLLHAIG DYAQSLFAGV RVRYVSSEEF TNDFINSIAN NRGAAFNARY RDVDILLIDD
     IQFLQGKAET QEAFFHTFNT LHDHDKQVVI TSDVAPKHLT GFEDRMRSRF EWGLITDVQA
     PDLETRIAIL RKKAQSERLY IPDDVVEYIA TVVSTNIREL EGALIRVSAF ASLNRSDVDI
     QLAQNVLRDI VEQTEDNVVS ESDIITATAA YFKLTVDDLY GSSRSQAVAQ ARQIAMYLCR
     ERTSLSLPKI GQLFGGRDHT TVMYAYKKIS ELMKERRSIY NQVTEITTQL GRR
//
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