ID A0A0Q7Z6C1_9SPHN Unreviewed; 484 AA.
AC A0A0Q7Z6C1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KQZ66033.1};
GN ORFNames=ASD67_01315 {ECO:0000313|EMBL:KQZ66033.1};
OS Sphingopyxis sp. Root1497.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingopyxis.
OX NCBI_TaxID=1736474 {ECO:0000313|EMBL:KQZ66033.1, ECO:0000313|Proteomes:UP000051141};
RN [1] {ECO:0000313|Proteomes:UP000051141}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1497 {ECO:0000313|Proteomes:UP000051141};
RA Garrido-Oter R., Bai Y.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQZ66033.1, ECO:0000313|Proteomes:UP000051141}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1497 {ECO:0000313|EMBL:KQZ66033.1,
RC ECO:0000313|Proteomes:UP000051141};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQZ66033.1}.
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DR EMBL; LMGF01000001; KQZ66033.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q7Z6C1; -.
DR STRING; 1736474.ASD67_01315; -.
DR Proteomes; UP000051141; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT ACT_SITE 60
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 60
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 167
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 316
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 325
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 329
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 484 AA; 53862 MW; 3713F0CEB100A583 CRC64;
MTAAALAKLL PGQADIQLIE SEEIGIVGVG EATLPHLREF IRRLGLDEME FMRTTRATFK
LGIDFVDFGA IGERYIHPFG AYGTDIAGVG FHHYWLRMQA AGQVPPICDF SLPIVAARGK
RFAPVPEGGD LLDSSYSYAY QFDATRMAPM LRRFAEAHGT RRTEGKVVAV ERDGASGDVA
RLRTDRGDVI GGDLFIDCSG FRALLIGETL KSPWEDWSEW LPCDRAAALP CAAPDGPIEP
YTRATAMPAG WRWRIPLQHR VGNGYVFSSN HVSEDEACAA ILGAVEGEPL ADPRVLRFRA
GRRTKSWDRN VVAIGLASGF LEPLESTSIH LVQQAVTRLV ELFPERRIDP ADRDSFNALV
DREYDRIRDF LILHYHATRR DDSDFWSHVR TMALPDELAR KMALWKESGR VELYTEGLFL
EASWIAVYLG QGVVPQGYDQ RADIPPQDRI AASLAELGGA IRQRVAAWPD HAEYLRQAGA
WEAA
//
