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Database: UniProt
Entry: A0A0Q8ED98_9ACTN
LinkDB: A0A0Q8ED98_9ACTN
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ID   A0A0Q8ED98_9ACTN        Unreviewed;       523 AA.
AC   A0A0Q8ED98;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   05-JUL-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ASD81_11385 {ECO:0000313|EMBL:KRA39131.1};
OS   Nocardioides sp. Root614.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=1736571 {ECO:0000313|EMBL:KRA39131.1, ECO:0000313|Proteomes:UP000051699};
RN   [1] {ECO:0000313|EMBL:KRA39131.1, ECO:0000313|Proteomes:UP000051699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root614 {ECO:0000313|EMBL:KRA39131.1,
RC   ECO:0000313|Proteomes:UP000051699};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KRA39131.1, ECO:0000313|Proteomes:UP000051699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root614 {ECO:0000313|EMBL:KRA39131.1,
RC   ECO:0000313|Proteomes:UP000051699};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRA39131.1}.
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DR   EMBL; LMGV01000001; KRA39131.1; -; Genomic_DNA.
DR   RefSeq; WP_056710199.1; NZ_LMGV01000001.1.
DR   EnsemblBacteria; KRA39131; KRA39131; ASD81_11385.
DR   Proteomes; UP000051699; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051699};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051699}.
FT   DOMAIN      214    342       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      426    495       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     222    229       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   523 AA;  57963 MW;  566140B22822B1B6 CRC64;
     MTGNPDQPQN DPNQDSATAR LGREWSAVVG ELQAHQRAWL QASRPVTLHG TTAIVAVPDD
     FTRKRLEGRL RSQLEDALTE RFGQEVQLAV TVDSTLRHDV PFEGGPAPYD QGPGYDQPRP
     AFEQPALEQS VDLSTKPQAD SSTYDAAAVV AAPGYDATFT PPDLNAANAA GPSATGSGET
     RLNPKYTFET FVIGSSNRFP HAAAVAVSEA PGKSYNPLLI YGESGLGKTH LLHAIGHYVR
     TIYAGSKVRY VSSEEFTNEF INAIRDDRQD RFKRKYREVD VLLIDDIQFL AGKTQTQEEF
     FHTFNTLHNA NKQIVLTSDR PPKLLEALED RLRNRFEWGL ITDVQAPDLE TRIAILRKKA
     AMDRLTAPSD VLEFIASKIQ TNIRELEGAL IRVTAFANLN RQDVDMTLAE IVLKDLIPDG
     GEPEITAPLI IAQTAAYFGL SIEELTGPSR GRHLVMARQI AMYLCRELTG LSLPKIGAQF
     GNRDHTTVMY AERKINQLLG ERRAVFNQVS ELTNRVKMQA RQG
//
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