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Database: UniProt
Entry: A0A0Q8LJ57_9MICO
LinkDB: A0A0Q8LJ57_9MICO
Original site: A0A0Q8LJ57_9MICO 
ID   A0A0Q8LJ57_9MICO        Unreviewed;       478 AA.
AC   A0A0Q8LJ57;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ASD93_13400 {ECO:0000313|EMBL:KRB37004.1};
OS   Microbacterium sp. Root180.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae;
OC   Microbacterium.
OX   NCBI_TaxID=1736483 {ECO:0000313|EMBL:KRB37004.1, ECO:0000313|Proteomes:UP000050802};
RN   [1] {ECO:0000313|EMBL:KRB37004.1, ECO:0000313|Proteomes:UP000050802}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root180 {ECO:0000313|EMBL:KRB37004.1,
RC   ECO:0000313|Proteomes:UP000050802};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KRB37004.1, ECO:0000313|Proteomes:UP000050802}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Root180 {ECO:0000313|EMBL:KRB37004.1,
RC   ECO:0000313|Proteomes:UP000050802};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRB37004.1}.
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DR   EMBL; LMHS01000003; KRB37004.1; -; Genomic_DNA.
DR   RefSeq; WP_056123507.1; NZ_LMHS01000003.1.
DR   EnsemblBacteria; KRB37004; KRB37004; ASD93_13400.
DR   Proteomes; UP000050802; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050802};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050802}.
FT   DOMAIN      171    299       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      383    452       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     179    186       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   478 AA;  53092 MW;  8DAA998233534A9C CRC64;
     MSPHEIPDVP VWSSVLDELS RDERITPQLQ GFLSLAVPQG VMGGTLYLDV PNDLTAAQFT
     KRMRTPIMEA LARVEQDSPQ PTSTFRVVVN PELADAHLTA PISVHVDSPS APASAPAGRS
     PMDETADAAP PVSRSDTRLN PKYTFDNFVI GQSNRFAHAA AVAVAEAPAK AYNPLFIYGD
     SGLGKTHLLH AIGDYAMSLY SGIRVRYVSS EEFTNDFINS IANNRGSAFQ ARYRDVDILL
     IDDIQFLQGR AETQEAFFHT FNTLHDHDKQ VVITSDVPPK HLTGFEDRMR SRFEWGLITD
     VQAPDLETRI AILRKKAQSE RLHIPDEVLE YIATVVSSNI RELEGALIRV SAFASLNRST
     LDMSLAQTVL RDIVDQDDAN VISPTDIITA TAAYFKLTVD DLYGSSRSQS VATARQIAMY
     LCRERTSLSL PKIGQLFGNR DHTTVMYAYK KISDLMKERR SIYNQVTEIT TQLGRNGR
//
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