ID A0A0Q8R3P7_9BURK Unreviewed; 623 AA.
AC A0A0Q8R3P7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=ASE26_28845 {ECO:0000313|EMBL:KRB91521.1};
OS Duganella sp. Root198D2.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Duganella.
OX NCBI_TaxID=1736489 {ECO:0000313|EMBL:KRB91521.1, ECO:0000313|Proteomes:UP000051728};
RN [1] {ECO:0000313|EMBL:KRB91521.1, ECO:0000313|Proteomes:UP000051728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root198D2 {ECO:0000313|EMBL:KRB91521.1,
RC ECO:0000313|Proteomes:UP000051728};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KRB91521.1, ECO:0000313|Proteomes:UP000051728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root198D2 {ECO:0000313|EMBL:KRB91521.1,
RC ECO:0000313|Proteomes:UP000051728};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557};
CC -!- SIMILARITY: Belongs to the bacterial reverse transcriptase family.
CC {ECO:0000256|ARBA:ARBA00034120}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRB91521.1}.
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DR EMBL; LMIC01000024; KRB91521.1; -; Genomic_DNA.
DR RefSeq; WP_057246788.1; NZ_LMIC01000024.1.
DR AlphaFoldDB; A0A0Q8R3P7; -.
DR Proteomes; UP000051728; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd03487; RT_Bac_retron_II; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000123; Reverse_transcriptase_msDNA.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR34047; NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR34047:SF7; RNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR00866; RNADNAPOLMS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051728};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 571..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 167..399
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 87..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 68884 MW; 1799D09FA211E81B CRC64;
MSATESKPVT TRAELMERLR NSSRQEVVLG EMQRLGFWPA NTGQPSELEE VVKREAELSS
ALNCLGQELR TIQDPEQALK AMRKERLAKA RQRREETRQK RARERFERAT AWHQRQSTEL
LYLGAGVSAG LNQAESNAEK LARWSLPTLN NASELATAMG VTLPELRFLS FERRVSRISH
YRRFAMPKKT GGERIISAPM PRVKRLQYWV LDNILGKVPL HDAAHGFIPG RSIVSNAQPH
VGKAVVINLD LKNFFPSISL PRIKGVFREL GYSEQLATTL GLICTETPVE EVSVDGERFF
VAIGERALPQ GAPSSPALTN ILCRRLDARV QSCAAKLGFA YTRYADDLTF SGDAAARKLA
GKLLWRVKQI IADEGFTPHP EKQHVMSDAQ CQSVTGIVVN KKLSLDRDTL RRFRATLFQV
EKDGPAGKQW NGNENVIDAL EGYAQFIRMV DGAKGGPLLQ QVRAVRAKWL ALAPAAGTPA
ARRSSGFRAL SAQGKEPWAG FWQAAAAPAP ELEKTQQQLT QEKTAARKKV VTPTSGPSRP
TARPAAEAPA AARGGRGTFT GRPWVAIIIQ VYFAITLCLN LHTPLPFVVA VMLAVPAWKN
YNAKWLRYFG AMFIAVLVGA LLR
//
