ID A0A0Q9Q585_9ACTN Unreviewed; 614 AA.
AC A0A0Q9Q585;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing) {ECO:0000313|EMBL:KRE94195.1};
GN ORFNames=ASG76_12500 {ECO:0000313|EMBL:KRE94195.1};
OS Nocardioides sp. Soil774.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=1736408 {ECO:0000313|EMBL:KRE94195.1, ECO:0000313|Proteomes:UP000051100};
RN [1] {ECO:0000313|EMBL:KRE94195.1, ECO:0000313|Proteomes:UP000051100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Soil774 {ECO:0000313|EMBL:KRE94195.1,
RC ECO:0000313|Proteomes:UP000051100};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KRE94195.1, ECO:0000313|Proteomes:UP000051100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Soil774 {ECO:0000313|EMBL:KRE94195.1,
RC ECO:0000313|Proteomes:UP000051100};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRE94195.1}.
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DR EMBL; LMSM01000008; KRE94195.1; -; Genomic_DNA.
DR RefSeq; WP_056603886.1; NZ_LMSM01000008.1.
DR AlphaFoldDB; A0A0Q9Q585; -.
DR STRING; 1736408.ASG76_12500; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000051100; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:KRE94195.1};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 42..131
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 220..352
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 434..569
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 614 AA; 65508 MW; 040ADAC55694B017 CRC64;
MSTIRTTTAD ALVRFLIAQR TVVDGVEVPL FPGTLAIFGH GNVTSLGQSL EAHRDQMPVW
RGQSEEGMGL AAAAFAKATR RRQIMVCTSS IGPGATNMVT AAGVAMANRL PVLFVAGDTF
NSRLPDPVLQ QVEHFGTPSV TVNDAFRPVV RFWDRLTHPA QVLASIPGAV RTMMDPAECG
PAFIGLPQDV AAEAYDYPAA FFEPRVHHWP RPRPDREELA RAARLIRAAR RPVLVAGGGV
HYSLAEDGLD RFVRAHRVPV VETVAGKSSL LGSHPHYVGP LGVTGADATN ALVEEADLVI
AVGTRLQDFT TGSWTLFAPQ AQVVTVNAAR FDAGKHFSAP VVGDARECLE ELDALLAGWT
CSVEWNERAT AARADLDRLV AARTGAEESS VLSYAQVVGA VHDEATEEDY VLTAAGGLPG
ELNINWSSKG VATFDCEYGF SCMGYEISGA WGAAFARDRG EVFALVGDGS YLMLNSDIYA
SVLSGKKFVL VVCDNAGFAV IERLQRGKGG ESYNNMLRDA RGSGSHERVD FAAHAAAMGA
RSVHVSGLDE LREALAAART HDRTSVIVVD VAESDWTPGG SYWQVGIPEV SESPAVVVAR
AESDAALVDQ RRGT
//
