ID A0A0Q9R420_9BACL Unreviewed; 2560 AA.
AC A0A0Q9R420;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=ASG93_18630 {ECO:0000313|EMBL:KRF09857.1};
OS Paenibacillus sp. Soil787.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1736411 {ECO:0000313|EMBL:KRF09857.1, ECO:0000313|Proteomes:UP000051948};
RN [1] {ECO:0000313|EMBL:KRF09857.1, ECO:0000313|Proteomes:UP000051948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Soil787 {ECO:0000313|EMBL:KRF09857.1,
RC ECO:0000313|Proteomes:UP000051948};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KRF09857.1, ECO:0000313|Proteomes:UP000051948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Soil787 {ECO:0000313|EMBL:KRF09857.1,
RC ECO:0000313|Proteomes:UP000051948};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRF09857.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMSP01000048; KRF09857.1; -; Genomic_DNA.
DR RefSeq; WP_056839303.1; NZ_LMSP01000048.1.
DR STRING; 1736411.ASG93_18630; -.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000051948; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 978..1053
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2031..2106
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2560 AA; 289377 MW; 25105225C926F3D7 CRC64;
MSQFKKEHVQ DMYFLSPMQE GMLFHYLLEQ GQSNAYFEQM SIRVRGTLDI GLFSVSLNRI
AQRYDVFRTV FLYEKVKRPV QVVLKERQIQ VHFENVSSLP EQERGLFVER FKQEDLERGF
DLSKDMMMRV SIIQTDESEY QIFWSHHHIL MDGWCLGIIV GELFQIYASL RKQAPIQLER
TYPYSDYIKW LERQDKEEAK RFWAEALSGY EQLASVPQKT AVVAGIAGLG YKQEELTIRF
DEKLTAKLQQ LSSKHQVTLN TVFQTIWGIV LQRYSHANDV VFGSVVSGRP SQVAGIEKMV
GLFINTIPVR VKSSADQSFS DVLQSVQLGA LAAESYTYLP LAEVQAQSVL KSNLFDHILV
FENYPVEESV QNGSLESQLG FEATDVSMIE QTSYNLNLLV MPGRELAVRL NYNANVYDIQ
FLRSIEGHLN TVARKIVEHP ELRLRDLVMV ADEEKQLLLQ LNDTREEVPS HLTVHRMFEE
QAEKTPDSVA VVFGERQLTY RELNERSNRL ARTLHGKNVG ADQAVGIMVE RSPDLVVGIL
AILKAGGAYV PIDPELPEER VNYMLHNSGA VILLTQSHLY GKVAFGGEII DISSDNITYD
SESSNLELSS STNDLFYIIY TSGTTGKPKG VMLEHRNMVN LLHHVFRHDN VNYGSTVLQY
TTMSFDVCYQ EIFSTLCSGG KLYLIDGDTK REVHKLLHIV EEAQIEVLFL PVSFLKFIFN
EQEYASRFPS CVRHIITAGE QLVVTNQLRS FLQKNGVKLH NHYGPSETHV VTIFQMEPNG
DIPELPSIGR PIANNGIYLL NDGLQLQPFG APGELFIAGD NVGRGYRNSD ELTAEKFMQN
PYRMGERMYR TGDLARWMPD GNLEFLGRID HQVKIRGHRI ELGEIESQLL NHPSVTAAAV
LDRKDAQGGT YLCAYYVSER PLHSQELRAY LLKELPEYMI PSFFMELGKL PVTPNGKTDR
RALPEPDGEF VTGTEYVPPT NVVEEALITI WKEVLGIARI GIHDNFFSLG GHSLKAMTLM
SRLNKHFSVN IPLRELFESP TAEGLARKIR EAEEDVRKAI QPAGKKPYYP VSSAQKRMFV
LQDLDDAGTG YNMPGVFIVC GELDRDLFEG TFARLIQRHE ALRTSFALID GEPVQKIHES
VEFKVEFSRL SEDTEDLAAE NKVIESLVER FMRPFDLQKA PLIRVALVEL QERRYLFMYD
MHHIISDGVS MSVIVKEFVQ LYGGGTLPEL SIQYKDYAVW QQAQLESESL RKQEAFWLNS
YAGELPQLEL PSDFPRPAVQ SFEGDHIRFE VDSELLGSLR RLAAENGSTL YMVLFAAYNV
LLSKYSGQED IVVGTPTAGR SQAELEHVVG MFVGTLALRS RPEGGKTFNS FLSEVKEYAL
QAFEAQEYPF DKLLEQLNIR RDPGRNPLFD TMFSMQSIDP GLGQEGGAGF GELTFTPHIW
QSGIAKFDLT LEVREGAGNL EFQLDYSTNL FAMETAERMA RHFVCLLERI VLVPDLTLAE
LSIVPNEEAW QIVQEFNHTS SDYPNSETIA TLFEKQAALT PDHPAVVYEG KQLTYRELNE
RANLLASELR KQGVGSDTVV GLLADRSIEL MIGLMGILKA GSAYLLLDLE MPAERIRFML
EDSDARIVLT QRKLYWMAQA ALAEQVIDLD EADLYEDGRN KENMEPVGSP RDLAYVIYTS
GSTGKPKGVL IEQRSVVRLV KETNYVQWSE DDRILQTGAL GFDAVTFEIF GALLNGGTLY
LADKSVILDS EKLGAFIADN RITTMWLTSP LFNQLSQENA ELFAGVRQLL VGGDALTSSH
INHVRYMCPG LRLINGYGPT ENTTFSTTFL IERDYEGSIP IGRPISNSTA YIVNKYNQLQ
PIGVPGELCV GGDGVARGYA NRPELTAETF VPNPFKEGET MYRTGDLAKW LPDGTIEYRG
RIDQQVKIRG YRIELGEIEA ELMKHPIMKD AVVIAREDAN GQKFLCAYVV AEQELGAPEV
KAFLAQELPS YMVPAYVVQM EKLPLTANGK IDRRELPEPE GGLGLGAEYA APRNMAEELL
CVIWQDVLGV PQVGIRDDFF QLGGHSLKAM TLLARIKQQL QVNVPLRMLF ESPTIEVLAQ
QIAQANKAAY TALKPVEPRD YYPVSSAQKR MFIMSQFKGS GTSYNIPGVM FIEGELDLER
FEQTFRRLIA RHESLRTTFE TVSGEAVQIV HTDVDFQVEY ARSTEDGLDS IVTEFVQPFN
LQKAPLLRVK LVHVSAQRYL LLFDMHHIVS DGVSMGILLH EFASLYHGDV LPELTVHYKD
FAVWLNSMIS SESMRVHEAY WLETFSGEIP VLALPTDYPR PAVQNFKGDA LTVRLGQPLR
DQIHMKASEY GATLYMVLLA AYQVLLSKYS GQTDVIVGTP VAGRPLTETE NILGMFVNTL
AIRSQPESGK TFAQFLEEVK RSSLLALEHQ HYPLETLIDQ LELRRDLSRN PLFDTVFSVQ
NQEMKASEFA GLRFEPYQRE NKIAQFDLSV KAIEDENEIV LHAEYAIHLF NKETIERMMT
DYQALLQQVT ENPDILLRDI TLAHFDKLEN VLDAAVEFLF
//
