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Database: UniProt
Entry: A0A0Q9TDI2_9ACTN
LinkDB: A0A0Q9TDI2_9ACTN
Original site: A0A0Q9TDI2_9ACTN 
ID   A0A0Q9TDI2_9ACTN        Unreviewed;       481 AA.
AC   A0A0Q9TDI2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ASG94_09840 {ECO:0000313|EMBL:KRF37944.1};
OS   Nocardioides sp. Soil805.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=1736416 {ECO:0000313|EMBL:KRF37944.1, ECO:0000313|Proteomes:UP000051356};
RN   [1] {ECO:0000313|EMBL:KRF37944.1, ECO:0000313|Proteomes:UP000051356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Soil805 {ECO:0000313|EMBL:KRF37944.1,
RC   ECO:0000313|Proteomes:UP000051356};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KRF37944.1, ECO:0000313|Proteomes:UP000051356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Soil805 {ECO:0000313|EMBL:KRF37944.1,
RC   ECO:0000313|Proteomes:UP000051356};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRF37944.1}.
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DR   EMBL; LMSU01000001; KRF37944.1; -; Genomic_DNA.
DR   EnsemblBacteria; KRF37944; KRF37944; ASG94_09840.
DR   Proteomes; UP000051356; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051356};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051356}.
FT   DOMAIN      172    300       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      384    453       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     180    187       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   481 AA;  53984 MW;  DFB1DBFA4F1205B9 CRC64;
     MEHQETDLGT VWRTIVRDLQ PNQRAWLRAS EPVTLHESTA IIAVPNDFTR NQLEGRLRGQ
     LEDSLSDALG REIRLAVTVN PALEDEAGPS AHVEASDQAP VDMSTKPHDD MSTMNGPTLG
     SPAEEPADAR RAGSALETRL NPKYTFETFV IGSSNRFPHA AAVAVAEAPG KAYNPLLVYG
     ESGLGKTHLL HAIGHYVRSL YTGAKVRYVS SEEFTNEFIN AIRDDRQDRF KRRYRDVDVL
     LIDDIQFLEG KTQTQEEFFH TFNTLHNANK QIVLTSDRAP KRLEALEDRL RNRFEWGLIT
     DVQPPDLETR IAILRKKAAM DRLTAPPDVL EFIASKIQTN IRELEGALIR VTAFANLNRQ
     EVDMTLAEIV LKDLIPEGGE PEITPGLIIA QSAAYFGVSI EDLTGPSRGR HLVMARQIGM
     YLCRELTDLS LPKIGAEFGN RDHTTVMYAD RKIRQLLAER RAVFNQVSEL TNRVKMQARQ
     S
//
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