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Database: UniProt
Entry: A0A0Q9W2A2_DROVI
LinkDB: A0A0Q9W2A2_DROVI
Original site: A0A0Q9W2A2_DROVI 
ID   A0A0Q9W2A2_DROVI        Unreviewed;      4042 AA.
AC   A0A0Q9W2A2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   22-NOV-2017, entry version 14.
DE   SubName: Full=Uncharacterized protein, isoform I {ECO:0000313|EMBL:KRF79235.1};
GN   Name=Dvir\GJ21297 {ECO:0000313|EMBL:KRF79235.1};
GN   ORFNames=Dvir_GJ21297 {ECO:0000313|EMBL:KRF79235.1}, GJ21297
GN   {ECO:0000313|FlyBase:FBgn0208429};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF79235.1, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:KRF79235.1, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH940648; KRF79235.1; -; Genomic_DNA.
DR   RefSeq; XP_015029614.1; XM_015174128.1.
DR   GeneID; 6625935; -.
DR   FlyBase; FBgn0208429; Dvir\GJ21297.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 2.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3371   3391       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3563   3581       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3647   3669       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3836   3858       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3912   3935       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    120       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      355    576       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4042 AA;  458936 MW;  E44D0864EE780CD9 CRC64;
     MVTMLQKCMP ERSSTLVFAT RLVTSLVVSS MLRSKPSEEK VYGGNSESFG KQCGPGDIVG
     VFLDLADHTI SFSLNGELLM DALGGETTFA DVTAEGVGFV PACTLGVGQK ARLIYGQDVD
     SLKFFTTCGL QEGYEPFCVN MRRPVTHWYT KDQPIFENTE EMPDCRIDVT RIPGGADTPP
     HLKISHNTFE TMEKANWEFL RLSLPVTCMS DFISEQEKAR RWEEIKIRQY RLMREAQEAA
     AQMQTQTVAH MDHMLKGGFN MNDIKGLTRN FDDHAEAEAE HMMRVPSRPS RKGSLTRNIT
     FESDMTAALD EMQRSSSVLD INGLGDDLDD KKKRGRSPFK FFSKKSRDQS REKNGARTAD
     ASLERRNTVA HGRNVVNQQM TTRTPTLRLN NAEIPPSPVP QGPKQLSSSN LGQPPVESSG
     NEMFDAECLK LINEYFYGVR IFPGQDPTHV YVGWVTTQYH LHSREFNKSK VRRGSVYIED
     YYEVPIERID RQSCYVVRAD ELFNEVTQDA SGKGASQGMF VGCFVDTATG IIRFTCEGKD
     TSHRWMMEPD TKLFPAIFVE ATSKEILQIE LGRTPTTLPL SAAVLPTSDK HINPQSPPRL
     KVQCLRPHQW ARVPNTSLQV HALKLSDIRG WSMLCEDPIS MLALHIPEED RCIDILELIE
     MDKLLSFHAH TLTLYAALCY QSNYRAAHAL CQHVDQKQLL YAIRSEYMSG PLRQGFYDLL
     IALHLESHAT TMEVCKNEYI TPLGVELKEL YAEDEMRHSL RSLVTESVRP QLRMTEITPP
     VIATSIMPSV SSEPIPNIDQ LYSPKFPLEV VREFVMEALK DAVEINQVHN RDPIGWTNEN
     LFLPLIKLTD RLLLVGVLTD EDVQKLLVMV DPETWDATFE KEGKDEHRKG LLTMKMAEGA
     KLQMCYLLHH LYDTQLRHRV ESIIAFSHDF VGDLQTDQLR RYIEIKQSDL PSAVAAKKTK
     EFRCPPREQM NQILCFKNLE VDDQDNCTCG LELRSRLSEF HDCLMQKVSL NALQEPDGTE
     SNAIEEIKTG PITKIYNFIN TVKELEEGPK EVEEPEKKTP EEIFRKVLIK TIVSWAEESQ
     IENPKLVREM FSLLVRQYDT VGELVRALEK TYVINNRARD DVAEMWVGLS QIRALLPVQM
     SQEEEELMRK RLWKLVNNAT FFQHPDLIRI LRVHENVMAV MMNTLGRRAQ AQSDAPTQTE
     GAEGVPSKEK DTSHEMVVAC CRFLCYFCRT GRQNQKAMFD HFDFLLDNAN ILLARPSLRG
     STPLDVAYSS LMENTELALA LREHYLEKIA VYLSRCGLQS NSELVEKGYP DLGWDPVEGE
     RYLDFLRYCV WVNGESVEEN ANLVIRLLIR RPECLGPALR GEGEGLFRAI VEANRMSERI
     SDRCKMQDEA EGTIAGLNFT HPLPEGDEDE DYIDTGAAIL NFYCTLVDLL GRCAPDVSVI
     EQGKNESLRA RAILRSLVPL EDLQGVLSLK FTLTQTAPGE ERPKSDMPSG LLPNNKQSIV
     LFLERVYGIE TQDLFYRLLE DAFLPDLRTA TILDKSDGSE SDMALAMNRY IGNSILPLLI
     KHSKFYNEAE NYASLLDATL HTVYRLSKNR MLTKGQREAV SDFLVALTSQ MQPAMLLKLL
     RKLTVDVSKL SEYTTVALRL LTLHFDRCAK YYGSTQGQGS YGASSDEEKR LTMLLFSNIF
     DSLSNMDYDP ELFGKALPCL IAIGCALPPD YSLSKNTDED YYGRQMGAPD QPQYVPNPID
     TNNVHLDNDL NSLVQKFSEH YHDAWASRRL EGGWTYGEVR SDNDRKHPRL KPYNMLSEYE
     RERYRDPVRE CLKGLLAIGW TVEHSEMDLP LNHRGSTRRQ SKPTIHDFQN EGSPFNYNPH
     PVDMSNLTLS REMQNMAERL AENSHDIWAK KKNEELDGCG GVIHPQLVPY DLLTDKEKKK
     DRERSQEFLK YMQYQGYKLH KPSKGGAVEE GGATQAAVEL RFSYSLLEKL IQYLDRATIN
     MKLLKPSTTF SRRTSFKTAS RDIKFFSKVV LPLMEKYFST HRNYFIAIAT ATNNIGAASL
     KEKEMVASIF CKLAALLRNR LSAFGPDVRI TVRCLQVLVK GIDAKTLTKN CPEFIRTSML
     TFFNQTSDDL GNTIMNLQDG KYSHLRGTHL KTSTSLGYVN QVVLPVLTAM FDHLAACDYG
     SDLLLDEIQV ASYKILAALY HLGTDATLTH DRKYLKTEIE RHRPALGSCL GAYSSCFPVA
     YLEPHLNKHN QYSLLNRIAD HSLEAQDIMV KMESCMPNLE AILSEVDQFV ESDKTYNDAP
     HIIDVILPLL CAYLPFWWSQ GPDNVSPTSG NHVTMVTADH MNSLLRNVLK MIKKNIGNDN
     APWMTRIAAY TQQIIINTSE ELLKDPFLPL AERVKKRTEN MLHKEESMRG FIKSATDDTS
     QVETQLQEDW NLLVRDIYSF YPLLIKYVDL QRNHWLKDNI PEAEELYNHV AEIFNIWSKS
     QYFLKEEQNF ISANEIDNMA LIMPTATRRS AISEGVPAVG GKVKKKKKNR DKKRDKDKEV
     QASLMVACLK RLLPVGLNLF AGREQELVQH CKDRYLKKMP EYDVIEFARN QLTLPDKLDP
     SDEMSWQHYL YSKLGKTEET VDEQALEKVN TNSNEKGKDK TTETVDRIVA MAKVLFGLHM
     IDHPQQQSKN VYRSVVSIQR KRAVIACFRQ TSLHSLPRHR ACNIFARTYY EQWLQEENVG
     QEVMIEDLTQ TFEESEKSKK DEEEADGKPD PLTQLVTTFC RGAMTERSGA LQEDLLYMSY
     AQIAAKSCGE EEEEGGEDGE AGEGGEEGEG TSIHEQEMEK QKLLFHQARL SNRGVAEMVL
     LHISASKGIP SEMVMTTLNL GIAILRGGNI DIQMGMLNHL KEKKDVGFFT SIAGLMNSCS
     VLDLDAFERN TKAEEYIPSA GAGLGVGSEG AAGEKNMHDA EFTCALFRFI QLTCEGHNLE
     WQNYLRTQAG NTTTVNVVIC TVDYLLRLQE SIMDFYWHYS SKEIIDPAGK ANFFKAIGVA
     SQVFNTLTEV IQGPCTLNQQ ALAHSRLWDA VGGFLFLFSH MQDKLSKHSS QVDLLKELLN
     LQKDMITMML SMLEGNVVNG TIGKQMVDTL VESAGNVELI LKYFDMFLKL ADLIESPSFH
     EIDMKNEGWV IPKDFREKME QSKNYTPEEM DFLLACCERN HEGKIDYRAF VERFHEPSKE
     IGFNLAVLLT NLSEHMPNEP RLARFLETAG SVLNYFEPFL GRIEILGSSK RIERVYFEIK
     DSNIEQWEKP QIRESKRAFF YSIVTEGGDK EKLEAFVNFC EDAIFEMTHA SGLMATDDGG
     SNVKRDTAYS SYMSEEEEER AARDPIRRTI TAVKEGLKFG VHMLSPSNIK HQIGVMQTKS
     IPELIVGFFK IIFYMFYYTG YAHYCVVRYI FGILLNLMRG PAPEQEEEEA VVEEETFGRA
     LPPLPLEEPP GTVQAFGLDI NKEENGMYKV VVHESPAGSS VEEGGESSPE DGAAATAEFI
     EGEPYQEPIS IVDLLGGEAA KKAAQERQEA QKAQEAAMAS IEAEAKKSSA APQETPAVHQ
     IDFSQYTHRA VSFLARNFYN LKYVALVLAF SINFMLLFYK VTSYPEESEG SGEDELILGS
     GSGGGADVAG SGLGGSGDGG SGDGDFDEDD IPELVHVDED FFYMEHVLRI AALLHSLVSL
     AMLIAYYHLK VPLAIFKREK EIARRLEFDG LFIAEQPEDD DFKSHWDKLV ISAKSFPVNY
     WDKFVKKKVR QKYSETYDFD SISNLLGMEK SAFTAQESEE TGILRYIMNI DWRYQVWKAG
     VTFTDNAFLY SLWYFSFSVM GNFNNFFFAA HLLDVAVGFK TLRTILQSVT HNGKQLVLTV
     MLLTIIVYIY TVIAFNFFRK FYIQEEDEEV DKKCHDMLTC FVFHLYKGVR AGGGIGDEIG
     DPDGDDYEVY RIIFDITFFF FVIVILLAII QGLIIDAFGE LRDQLESVKD NMESNCFICG
     MGKDFFDIVP HGFDTHVQKE HNLANYMFFL MHLINKPDTE YTGQETYVWN MYQQRSWDFF
     PVGDCFRKQY EDELSGGGGG GG
//
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