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Database: UniProt
Entry: A0A0Q9WBJ8_DROVI
LinkDB: A0A0Q9WBJ8_DROVI
Original site: A0A0Q9WBJ8_DROVI 
ID   A0A0Q9WBJ8_DROVI        Unreviewed;      2080 AA.
AC   A0A0Q9WBJ8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|FlyBase:FBgn0015214};
GN   Synonyms=Dvir\para {ECO:0000313|EMBL:KRF82092.1};
GN   ORFNames=Dvir_GJ19029 {ECO:0000313|EMBL:KRF82092.1}, GJ19029
GN   {ECO:0000313|FlyBase:FBgn0015214};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF82092.1, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:KRF82092.1, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH940651; KRF82092.1; -; Genomic_DNA.
DR   RefSeq; XP_015026560.1; XM_015171074.1.
DR   GeneID; 6631799; -.
DR   FlyBase; FBgn0015214; Dvir\para.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    134    161       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    205    227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    239    257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    285       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    395    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    776    799       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    820    837       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    849    873       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    904    926       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    984   1005       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1293   1315       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1321   1347       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1368   1399       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1486   1512       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1575   1593       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1605   1624       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1636   1655       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1699   1722       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1785   1808       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1829   1864       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      421    456       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2080 AA;  233748 MW;  3F96F6816FA44674 CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV IRYDDEDEDE
     GPQPDPTLEQ GVPIPVRLQG SFPPELASTP LEDIDPYYSN ILTFVVVSKG KDIFRFSASK
     AMWLLDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTVEST EVIFTGIYTF
     ESAVKVMARG FILCPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT FRVLRALKTV
     AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC IKKFPLDGSW
     GNLTDENWDY HNRNSSNWYS EDDGISFPLC GNISGAGQCD DDYVCLQGFG PNPNYGYTSF
     DSFGWAFLSA FRLMTQDFWE DLYQLVLRAA GPWHMLFFIV IIFLGSFYLV NLILAIVAMS
     YDELQKKAEE EEAAEEEAIR EAEEAAAAKA AKLEERANAH AQAAADAAAA EEAALHPEMA
     KSPTYSCISY ELFVGGEKGN DDNNKEKMSI RSVEVESEST SLSLPGSPFN IRRGSRSSHK
     YTIRNGRGRF GIPGSDRKPL VLSTYQDAQQ HLPYADDSNA VTPMSEENGA IIVPVYYGNL
     GSRHSSYTSH QSRISYTSHG DLLGGMAVMG VSTMTKESKL RNRNTRNQSV GATNGGTTCL
     DTNHKVEHRD YEIGLECTDE AGKIKHHDNP FIEPVQTQTV VDMKDVMVLN DIIEQAAGRH
     SRASDRGVSV YYFPTEDDDE DGPTLKDRAL EVILKGIDVF CVWDCCWVWL KFQEWVSLIV
     FDPFVELFIT LCIVVNTMFM AMDHHDMNKE MERVLKAGNY FFTATFAIEA TMKLMAMSPK
     YYFQEGWNIF DFIIVALSLL ELGLEGVQGL SVLRSFRLLR VFKLAKSWPT LNLLISIMGR
     TMGALGNLTF VLCIIIFIFA VMGMQLFGKN YHDHKDRFPD GDLPRWNFTD FMHSFMIVFR
     VLCGEWIESM WDCMYVGDVS CIPFFLATVV IGNLVVLNLF LALLLSNFGS SSLSAPTADN
     DTNKIAEAFN RIGRFKSWVK RNVADCFKLI RNKLTNQISD QPSGKGVCRC ISAEHGDNEL
     ELGHDEILAD GLIKKGIKEQ TQLEVAIGDG MEFTIHGDMK NNKPKKSKYL NNATDDDTAS
     INSYGSHKNR PFKDESHKGS AETMEGEEKR DASKEDLGLD EELDEEGECE EGPLDGDIII
     HANDEDILDE YPADCCPDSY YKKFPILAGD EDSPFWQGWG NLRLKTFQLI ENKYFETAVI
     TMILMSSLAL ALEDVHLPQR PILQDILYYM DRIFTVIFFL EMLIKWLALG FKVYFTNAWC
     WLDFVIVMVS LINFVASLVG AGGIQAFKTM RTLRALRPLR AMSRMQGMRV VVNALVQAIP
     SIFNVLLVCL IFWLIFAIMG VQLFAGKYFK CEDLNGTKLS HEIIPNRNAC ESENYTWVNS
     AMNFDHVGNA YLCLFQVATF KGWIQIMNDA IDSREVDKQP IRETNIYMYL YFVFFIIFGS
     FFTLNLFIGV IIDNFNEQKK KAGGSLEMFM TEDQKKYYNA MKKMGSKKPL KAIPRPRWRP
     QAIVFEIVTD KKFDIIIMLF IGLNMFTMTL DRYDASDTYN AVLDYLNAIF VVIFSSECLL
     KIFALRYHYF IEPWNLFDVV VVILSILGLV LSDIIEKYFV SPTLLRVVRV AKVGRVLRLV
     KGAKGIRTLL FALAMSLPAL FNICLLLFLV MFIFAIFGMS FFMHVKEKSG INDVYNFKTF
     GQSMILLFQM STSAGWDGVL DAIINEEACD PPDNDKGYPG NCGSATVGIT FLLSYLVISF
     LIVINMYIAV ILENYSQATE DVQEGLTDDD YDMYYEIWQQ FDPEGTQYIR YDQLSEFLDV
     LEPPLQIHKP NKYKIISMDI PICRGDLMYC VDILDALTKD FFARKGNPIE ETGEIGEIAA
     RPDTEGYEPV SSTLWRQREE YCARLIQHAW RKHKTRAEAG GGDPDADAAN DMDPDPAAGD
     DAPDDNAAAD DDPDAAGANG GHDPAADGAA VDPANDPKSI VNSPMDGGGG SPGGQSAGSG
     GSAGRQTAVL VESDGFVTKN GHKVVIHSRS PSITSRTADV
//
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