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Database: UniProt
Entry: A0A0Q9WBQ0_DROVI
LinkDB: A0A0Q9WBQ0_DROVI
Original site: A0A0Q9WBQ0_DROVI 
ID   A0A0Q9WBQ0_DROVI        Unreviewed;      2118 AA.
AC   A0A0Q9WBQ0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|FlyBase:FBgn0015214};
GN   Synonyms=Dvir\para {ECO:0000313|EMBL:KRF82099.1};
GN   ORFNames=Dvir_GJ19029 {ECO:0000313|EMBL:KRF82099.1}, GJ19029
GN   {ECO:0000313|FlyBase:FBgn0015214};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF82099.1, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:KRF82099.1, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH940651; KRF82099.1; -; Genomic_DNA.
DR   RefSeq; XP_015026521.1; XM_015171035.1.
DR   GeneID; 6631799; -.
DR   FlyBase; FBgn0015214; Dvir\para.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    160       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    204    226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    238    256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    262    284       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    394    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    799    822       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    843    860       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    872    896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    927    949       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1007   1028       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1331   1353       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1359   1385       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1406   1437       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1524   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1613   1631       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1643   1662       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1674   1693       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1737   1760       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1823   1846       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1867   1902       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      420    455       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2118 AA;  238100 MW;  D79942DD7DDD38AC CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEI RYDDEDEDEG
     PQPDPTLEQG VPIPVRLQGS FPPELASTPL EDIDPYYSNI LTFVVVSKGK DIFRFSASKA
     MWLLDPFNPI RRVAIYILVH PLFSLFIITT ILVNCILMIM PTTPTVESTE VIFTGIYTFE
     SAVKVMARGF ILCPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA
     IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KKFPLDGSWG
     NLTDENWDYH NRNSSNWYSE DDGISFPLCG NISGAGQCDD DYVCLQGFGP NPNYGYTSFD
     SFGWAFLSAF RLMTQDFWED LYQLVLRAAG PWHMLFFIVI IFLGSFYLVN LILAIVAMSY
     DELQKKAEEE EAAEEEAIRE AEEAAAAKAA KLEERANAHA QAAADAAAAE EAALHPEMAK
     SPTYSCISYE LFVGGEKGND DNNKEKMSIR SVEVESESVS VIQRQPAPTT AHQATKVRKV
     STTSLSLPGS PFNIRRGSRS SHKYTIRNGR GRFGIPGSDR KPLVLSTYQD AQQHLPYADD
     SNAVTPMSEE NGAIIVPVYY GNLGSRHSSY TSHQSRISYT SHGDLLGGMA VMGVSTMTKE
     SKLRNRNTRN QSVGATNGGT TCLDTNHKVE HRDYEIGLEC TDEAGKIKHH DNPFIEPVQT
     QTVVDMKDVM VLNDIIEQAA GRHSRASDRG VSVYYFPTED DDEDGPTLKD RALEVILKGI
     DVFCVWDCCW VWLKFQEWVS LIVFDPFVEL FITLCIVVNT MFMAMDHHDM NKEMERVLKA
     GNYFFTATFA IEATMKLMAM SPKYYFQEGW NIFDFIIVAL SLLELGLEGV QGLSVLRSFR
     LLRVFKLAKS WPTLNLLISI MGRTVGALGN LTFVLCIIIF IFAVMGMQLF GKNYTDHKDR
     FPDGDLPRWN FTDFMHSFMI VFRVLCGEWI ESMWDCMYVG DVSCIPFFLA TVVIGNLVVL
     NLFLALLLSN FGSSSLSAPT ADNDTNKIAE AFNRIGRFKS WVKRNVADCF KLIRNKLTNQ
     ISDQPSEHGD NELELGHDEI LADGLIKKGI KEQTQLEVAI GDGMEFTIHG DMKNNKPKKS
     KYLNNATMIG NSINHQDNRL EHELNHRGLS LQDDDTASIN SYGSHKNRPF KDESHKGSAE
     TMEGEEKRDA SKEDLGLDEE LDEEGECEEG PLDGDIIIHA NDEDILDEYP ADCCPDSYYK
     KFPILAGDED SPFWQGWGNL RLKTFQLIEN KYFETAVITM ILMSSLALAL EDVHLPQRPI
     LQDILYYMDR IFTVIFFLEM LIKWLALGFK VYFTNAWCWL DFVIVMVSLI NFVASLVGAG
     GIQAFKTMRT LRALRPLRAM SRMQGMRVVV NALVQAIPSI FNVLLVCLIF WLIFAIMGVQ
     LFAGKYFKCE DLNGTKLSHE IIPNRNACES ENYTWVNSAM NFDHVGNAYL CLFQVATFKG
     WIQIMNDAID SREVDKQPIR ETNIYMYLYF VFFIIFGSFF TLNLFIGVII DNFNEQKKKA
     GGSLEMFMTE DQKKYYNAMK KMGSKKPLKA IPRPRWRPQA IVFEIVTDKK FDIIIMLFIG
     LNMFTMTLDR YDASDTYNAV LDYLNAIFVV IFSSECLLKI FALRYHYFIE PWNLFDVVVV
     ILSILGLVLS DIIEKYFVSP TLLRVVRVAK VGRVLRLVKG AKGIRTLLFA LAMSLPALFN
     ICLLLFLVMF IFAIFGMSFF MHVKEKSGIN DVYNFKTFGQ SMILLFQMST SAGWDGVLDA
     IINEEACDPP DNDKGYPGNC GSATVGITFL LSYLVISFLI VINMYIAVIL ENYSQATEDV
     QEGLTDDDYD MYYEIWQQFD PEGTQYIRYD QLSEFLDVLE PPLQIHKPNK YKIISMDIPI
     CRGDLMYCVD ILDALTKDFF ARKGNPIEET GEIGEIAARP DTEGYEPVSS TLWRQREEYC
     ARLIQHAWRK HKTRAEAGGG DPDADAANDM DPDPAAGDDA PDDNAAADDD PDAAGANGGH
     DPAADGAAVD PANDPKSIVN SPMDGGGGSP GGQSAGSGGS AGRQTAVLVE SDGFVTKNGH
     KVVIHSRSPS ITSRTADV
//
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