ID A0A0Q9WL47_DROVI Unreviewed; 8945 AA.
AC A0A0Q9WL47;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Uncharacterized protein, isoform AC {ECO:0000313|EMBL:KRF85432.1};
GN Name=Dvir\GJ15760 {ECO:0000313|EMBL:KRF85432.1};
GN ORFNames=Dvir_GJ15760 {ECO:0000313|EMBL:KRF85432.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF85432.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF85432.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; CH940665; KRF85432.1; -; Genomic_DNA.
DR RefSeq; XP_015024020.1; XM_015168534.1.
DR EnsemblMetazoa; FBtr0444605; FBpp0400929; FBgn0202948.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 39.
DR CDD; cd00096; Ig; 3.
DR CDD; cd05748; Ig_Titin_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 78.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR PANTHER; PTHR14340:SF21; MYOSIN BINDING PROTEIN C2; 1.
DR Pfam; PF00041; fn3; 38.
DR Pfam; PF07679; I-set; 35.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 39.
DR SMART; SM00409; IG; 38.
DR SMART; SM00408; IGc2; 31.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 21.
DR SUPFAM; SSF48726; Immunoglobulin; 39.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 39.
DR PROSITE; PS50835; IG_LIKE; 31.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 122..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..324
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..429
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 441..534
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 546..638
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 643..731
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 749..838
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1732..1810
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1827..1911
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2105..2202
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2205..2303
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2307..2397
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2404..2500
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2506..2601
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2703..2800
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2806..2900
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2905..2997
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3001..3100
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3106..3201
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3205..3294
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3302..3396
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3403..3498
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3502..3592
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3600..3693
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3699..3794
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3798..3887
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3895..3988
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3994..4089
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4093..4181
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4188..4282
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4288..4387
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4391..4480
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4488..4581
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4584..4682
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4686..4777
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4783..4876
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4882..4976
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4979..5069
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5077..5172
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5178..5272
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5277..5366
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5374..5467
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5473..5567
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5532..5660
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5667..5761
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5767..5862
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5962..6059
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6065..6160
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6164..6253
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6262..6356
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6362..6455
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6462..6557
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6551..6648
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6657..6751
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6757..6852
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6953..7047
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7053..7148
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7154..7249
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7255..7345
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7448..7543
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7549..7644
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7644..7738
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7743..7836
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7841..7934
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7991..8246
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 8314..8402
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8439..8526
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8644..8732
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8752..8840
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8851..8939
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 839..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3184..3204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3677..3707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3973..3999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5153..5183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5449..5478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6438..6485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6540..6565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6737..6761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8555..8629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1362..1376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5449..5465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8561..8628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 8020
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 8945 AA; 1000697 MW; 2740840E0509EEB2 CRC64;
MGVAEDFAPS FVKKPQLHQE DDGNRLIFEC QLVSSPKPDI EWFRSDNKLT EDARTKFKIQ
PIGDNKFTVV LELDDVVETD AGLYKVKAKN KSGEVSASIN LNFTLGKFSL LEDLRQIDGF
APTFAKKPAI RQEEDGKRLL FECRVNADPL PNITWFHNGT TVQESPRHRL TIDKDVHSYF
ATLEIQNVTV EDAGKYKVNA KNELGESNAT ISLNFDSDEA PVPESTDGIK PTFTERPVIR
QSEDGGNVTF ECRCVGDPTP TVTWSHGETV LSEGKRYKMS LTLDQKLYHM ARLEISSVVS
SDQGEYRAQA KNKHGSGVAT INLNFESGSK KIPDGKSPRF PKKPTIRQEE DILIMECILE
AHPVPDITWY CSDKQILDNQ RTKMTRKAIT KDSYVLTLEI QYPTKDDGGN YRCNAINMFG
ESNANIALNF QGANDANGFA PSFIEKPRII PNETGTLITM KCKCKAKPEP TVKWYRGQDL
VEKSKKIKIN STVIAEDTYE LTLEIKDPGA TDGGTYRCNV KNEYGESNAN LNLNIEAEPE
PEGEGPTFIE KPRIISENNG KLVIMECKVK ADPKPDIVWF RNGEVIKESN KLKIFMEQRG
DQYYIKLELI DPQLEDSGLY KCNIKNSLGE LNANLTLNIE IVPVIKDKPK IIKIIKKRTV
VIECVVVSKF EPKCTWYKET NTVAESKRHV YLVEKTKEGE FAVKLEINEV EDSDKGAYKL
VASNEKGEAV SQVVNLVDIP EEERKPSKPD IARKLVDQKV TESKTFELII SLKNSDRKCK
VEWYKGSTLI RETKDITTTF DGTTARLTFS SAKSEHTSNY KVVVSNELGK DESTCKVTVE
KKDKKKDEKS EQDKEKEEAE KKRKVIETKT KTKTKEISQQ EDLAEREQQT NQISLKVQNN
QIVNQQISVT SYEQAYIQEQ QSTLIVQQTK QTEQQQVSET HVSYSSEVQK AHHQELLVQE
HSSPKVQAKV SSTCTIETQP TSGLTIYQIP KLKSRKTSEP PVNASESKEK NIFGVKLTPV
RHVLNDEEPA EQIGLKKVER RASIVSVKEE SKSETRRKSI IKSHEQTSEE DTKTVSRRSS
FAVEENVSES RRSSVVDKKA LEQVESKKIE ANNNPQAIKE EIPKLKPADK RRIPKAVEEQ
KPAEELPKLR KTSIAKPKEE PIPEAAKPKA KGKLKAKPKY EELPEIPDYE RPALEKYEKS
DFTPSDFARE LEIPNKMEKP ALETAKKPAE IVPQKNGLPK KTEVVEQPAE EPKTIKLGKG
KLPDDEDTRD GATLKPVIVE PEKDKQNTDK SEEANITENF NPTKSSKAQI SDMKKPEALA
TIVDDYERPK LEKYEPIEFE KTKSEKPTPV VKSPDQNTPE VKLPVEDSKE EKPKVPKMQP
PAPGDPPKIE VIREKRPSLA PEPPSRRGSL VPPADTGRRP SLIINDEKKL RPGEVMDTRL
LRPGEVGEGQ QKQQRPGEMG DTKQRRRPSI DVRRPSVQDL EDLINKPSTP LRDIGDGGPP
TIIDVQESYS AVEDSTAYLT VGVEGNPAPT FKFYKGVTEI IEGGRYKFLT DGQTNTITLC
MRKCKPNDEG KYKVVVSNIH GEDSAEMQLY VSDSSGMDFR AMLKKRRYQK WDKEEQDPNW
GDLKETEKPL PALKKVERKV ESFLSPLIDQ FAKEGKDKKV VFEARFSKPN CKPKWLFRKD
EVFTGSKFKF KQENDTYQLI ISTPKVEDSG KYTIEIGGVS STAFLNVEEA DPTYTFTKPL
KKKLEGFTRH ETTLECSVSS SMANVSWFKD NQKLESDDPR YLISKDINGN LKLIIKESVL
EDAGQYRCQL DKQPDKTECA LKIVEYPYKF VKVLKSQQCV EKDTVTLACE IDDAQGDVQW
FRNGEEIKPD KRMQVVKDGR KRKLIIKDCK VTDAGQFKCT TNADQTDAEI IINYQNRFNK
KLKDTDAVER EKLVLDVELQ DQTAPCDWKF NGEPIVPNER IEIKNLGGGK HQLVFNGLDL
SDAGEITCES GQLTSTCKLS VRKGESRPNI DCPDEFAEPI SAPVVIEVPY KVSGTKQTPV
EGKLIKDGKP LPLKDVEVAI TDDKITFKIK KPSRDLSGPY QIKISNAQGE DTKDVNIICQ
DVPQPPQDVD VTDVYQTSCV VNFKPPTDDG GSPITKYVIE RQDLSKKQGW EPVAEVLPNE
PRLKKIDDLV PKKQYRFRIR AVNKLGPSDP ATFKNSILAK DPWDEPGKPK AVDLTDWDKD
HADLKWEAPD SDGGDPITSY VIEYKEKFSN DWVPGREVPG DARTGTVENL KEGQQYEFRV
RAVNRAGPGE PSDKTKPIIA KCRFVKPFLV GDGLKNITVK KGQTIRYDIK YDGEPEPVAS
WIKSNEPLKF DNQRICLEQL ERNSSITIKK SVRNDTGKYK LVLTNSSGTI ESEAQVVVLD
RPLAPGGPFE PEEVRAHRIK MKWKRPPDDG GCEITGYALE RMDEETGRWI PSGEVGPDET
SFDFKGLTPN KKYKFRVKAI NKEGESEPLE TTDAILAKNP YDPPSPPSQP VIDDYDNKSV
SLKWKRPPSD GGRPVTHYVV EFKDKFSPTW SEVAKTEDPT PECKVEGLKE KMVYQFRVRA
VNKAGPSEPS QPTDNHLCKH KNLKPQIDRS TFKRVTIKSG RTHKWSVDIT GEPVPELHWS
WRDDIALTTG DRISIENVDY HTDFVIMNAK RQDSGFYSLK AENRNGVDRE TVELVVLGKP
SSPKGPLAVS DVTATGCKLQ WKKPEDDGGI PIKEYVVEKM DTATGKWVRV GRSPGEKEPP
SFDVTGLNPG SEYMFRVSAV NEEGESEPLT TLVGVVAKDP FDEPNKPGTP EVIDYDNQSI
SLKWTPPKND GGAPIQKYII EKKDKNKPDW EKALEIPGDQ LEAAVAGLQE YGEYQFRVIA
VNKAGPSPPS DASVPQVAKY KKLKPRIDRS NLKPLLIRAG KPIKYDVNVR GEPVPTITWY
QNDKELKPED LPTNCEIQNI PHNTKISIID TVRKHTGTYK IRAVNEHGED EADVEVNVLA
PPGKPKGPLA VKDITKDSCK LKWQKPDDDG GKPITAYQVE KFDKKQGRWV PVGRASGNDT
EFDVKGLQEG HEYQFRVKAI NEEGESEPLE TDGSILAKNP YDAASKPGTP KIDDYNEHMV
KLKWDAPKHD GGAPITGYII EKKDKFSPIW DEVFTTNTPA PEAIVDGLTE GNVYQFRVRA
INKAGTSEPS DPTEPHLAKP RNLKPSINRE KMKPVKVRAG QTVKFDVDVK GEPAPTLTWS
FKEKEVTPSG QLRLDNDDYN TKLVLLDTTR KDTGVYKLKA ENINGVDEAE VEVIILDKPA
KPEGPLEVSD IHKEGCKLKW KKPKDDGGVP LSGYAIEKMD TATGKWVPCG TVDPEKTEFD
VKGLDPNHRY QFRVRALNEE GESEPLETES AITAKNPFDI SAPPGLPELE DWDEHHVKLK
WEPPIRDGGT PITNYIIEVM DKDSGEFVKA SETEGPICKG VVKKLEEGQQ YKFRVRAVNK
AGPSEPSEQT NWHTAKPRFL KPHIDRTNLK PVIVKAGLSI SLDINVKGEP APKVEWLFNG
LPVISDEEGI KIDNVDYNTK FFVMRAKRPQ SGKYTIKATN EVGEDVADLD VTVLGKPGKP
KGPLEVNDMT KHSCKLKWEK PEDDGGAPID YYEIEKLDPH TGQWLPCGKS AEPEAKVIGL
HEGKPYKFRV RAVNKEGESE DLETDKPVIA KNPFDEPDKP GRPEPTNWDK DFVDLAWDPP
KNDGGAPIQK YIIQMRDKSG RAWVDAATVP SDKTKGTVTA VEEGHEYEFR VVAINKAGPS
EPSDVSKSVV AKPRFLKPHI DRKNLQKKIM RSGQMLHMDA AVKAEPPAKI TWTYNGAEIK
TSDKIKIENE EYKTTFIMPK VRRADKGTYI VTAKNDSGVD TVDVELEVLC KPSKPKGPLA
VSDVTAESVH LKWHKPDDDG GEPIEHYVVE RMDTETGRWV PVLTTKTPEA DVTGLTEGKE
YLFRVKAVNA EGESEPLVTD TPVTAKNPYD AADTPGKPQI TDWSANHADL KWRAPDDDGG
APITGYIIEK KDNNTGKWQK VLETNTPDCK TRVNDLIEGT KYQFRVKAVN KAGQSKPSEA
SDQMSAKDRF AAPKIDRTNI KDITVKAGQH IRFDIKVSGE PPPSKTWFHN KARIDDDDYN
IDIESYRTKL AVPFAKRLHS GKYTIKAENE SGHDEASFEV TVLDKPAPPE GPLRVTDVHK
EGCKLKWNPP MDDGGLPIEH YVVEKMDVET GRWLPSGRFK EPFAELNNLE PGHEYKFRVL
AVNTEGESEP LVGEHSIVAK NPFDEPGKPG TPEPVDWDKD RVDLVWRPPL NDGGSPITGY
VVEKREKGTD KWIKGAEINA PALGEECKAS VPNLDENCEY EFRVKAFNAA GSGEPSDASK
SVITRPRKLA PKIDRKNIRT YNIKAGEPIF LDINVSGEPA PEISWTQNGK IVYSTPATKI
ENVPYNTKYI NSNPERKDTG LYKIAAHNLY GQDQVEFQIN VITKPGKPEG PLEVSDVHKD
GCKLKWKKPK DDGGEPIDSY LVEKFDPDTG VWLPVGKSAV PEITVDGLIP GHEYKFRVKA
VNKEGESEPL ETLGSIIAKD PFTAPSKPGV PETTDWTANK ADLAWNESAS DGGSPITGYI
IEIKDKYSPL WEKALETDSP SPVATVNGLI EGNEYQFRVI ALNKGGQSEP SEASKPFIAK
PRYLAPKIDR RNLRDVTISA GTALKLDAVI TGEPAPKVEW KFSNYPLQSG KNTTIETPDY
YTKLVIRPTQ RGDSGEYLVT ATNSSGKDSV LINVNITDKP TPPNGPLQIS DVHKEGCHLK
WKRPNDDGGT PIEYFQIDKL DPETGYWLPC GRSTEPQADI TGLTPGNEYK FRVSAVNAEG
ESAPLVGEES IIAKNPFDEP GKPENLRATD WDKDHIDLAW TPPLNDGGSP VTGYLVEKKD
KYGQWEKALE VPADQCKGTV PDLTEGEAYE FRVSAINAAG LGEPSDATAP IVAKSRNKPP
VIDRSNLIEV RIKAGQAFTF DCKISGEPAP KTKWLLKKKE VFSKDNIKVT HIDYNTKLKV
TNANRSDSGL YTVHAENYNG EDSADVKVTV IDKPSPPNGP LKVENVHAEG CTLNWNPPDD
DGGQPIENYA VEKMDEATGR WVPAGESHGP VTSLKLKGLT PGHKYKFRVR AKNRQGTSDP
LTTHHATEAK NPYDEPTKPG TPSIKDFDKD FVDLEWARPE SDGGSPISGY IIEKRDKYSP
NWEPCAEIDG DVTSGHVSDL IEGVKYEFRV RAVNKAGQGV PSDATEPHVA RAKNVAPKID
RNFMLDIKIR AGNVFEFDVP VSGEPIPSKE WTHEDNMVIN TDRVKISNYD DRTKLRILDA
KRADTGSYTL VARNINGIDK HTVKVTVLDV PTAPEGPLRG DEITKNSMTL RWRPPKDDGG
SEITHYVVEK MDNEAMRWVP VGECAGTEIR ADNLIENHDY NFRVRAVNKQ GQSQPLTTSQ
AITAKDPYSH PDKPGQPQAV DWGKNFVDLE WAAPKRDGGA PITSYIVEKR PKFGQWERAT
VVPGDERKAH IPDLTDGGEY EFRVIAVNRG GQSDPSDPSG TIVCKPRFLA PFFDKSLLDN
ITVHAGKRLG WTLPIEASPR PTIKWLFNGK EIEPSTRIES NLFQNELTFE IPSALRADEG
RYTLILKNEH GSFDASAHAT VLDRPSPPKG PLDISKITRD GCHLAWHVPD DDGGSPILHY
IIEKMDLSRG TWSDAGMSTH PVHDVIRLVH CKEYLFRVKA VNAIGESEPL EASKSIIAKN
EFDEPDSPSK PIVTDWDRDH VDLQWAAPKS DGGAPLTEYI IQKKEKGSPY WVNVVHVPPN
KTAATVPDLV EGQEYEFRVI AVNQAGQSEP SEPSDMIMAK PRFLAPKIIT PLHEVRIKAG
LIFHIDIDFI GEPAPEAIWT HNLNSLKSNE RSTITTIGHH TVVHTVNCQR SDSGIYHLLL
RNDSGIDEGS FELIVLDRPG PPDGPLEYEE ITANSVTISW KPPKDNGGSE ISAYVIEKRD
LTHGGGWVPA VSFVNAKYNH AVVPRLLEGT KYEFRVMAEN LQGRSDPLTS EQPVIAKNQY
TVPGAPGKPE LSDSDKDHIT IKWKQPISNG GSPILGYDIE RRDVNTGRWI KINGEPVPTT
EYRDDRVSPN HQYQYRVSAV NAAGNSKPSE PSSTFNARPM REKPRLYLDG LVGRRIKVRA
GEPVNVNIPI SGAPTPTIEW KRGDVKLPES KNVSYDTNSE RTIFRIDDST RQDSGVYKIT
ATNEFGKDSA DVKIIVVDKP TPPEGPLTYT ETAPDHISLQ WNPPKDDGGS EITGYIIEFT
EFSVDDWKPV PGYCPKTNYT VKGLTEGKKY LFRVRAENIY GVSDALEGKP VVAKSPFDPP
GAPSQPQVVA YTPSSASLEW HPPDYCGGKP ISGYIVERRE RGGEWIKCNN YPTPNTSYTV
PDLREGARYE FRVIAVNEAG PGSPSKPSEP MTAELQRYRP DPPEPPKPDR ITKDSVTLSW
RPPRNDGKSK IKGYYIEMRP KNSKDWKPVN DIPIHSTVFR VPDLKEGEEY WFRVIAENDV
GRSDPSKPSQ PITIEEQPNK PRMDLGGVRD IICRAGDDFS IHVPYVGFPK PTASWYSNDT
VLDDDQRVHQ HLTDEAASFV VKNSKRSDSG QYRLQLKNPS GFDTATINVK VLDRPGPPTN
LRADEFAGDS LTLYWNPPKD DGGSPVQNYI IEKKEARSST WTKVSSYCTV PFVRIRNLTI
GKEYDFRVIA ENKYGQSDPA NTSEPIRARH PFDVPNAPGI PRGIDSTEDS ITIAWSKPKH
DGGSPITGYV IEKRLLSEDK WTKAIHALCP DLTCKIPNLI ENAEYEFRVA AVNAAGQSLF
SASSDLIYCR RPPHAPKITS DLSIRDMTVI AGEEFHITVP YHANPRPVPS WNINGLEVSP
DERIRFDTDD YSSVYHNKCA KRSETGSYTI TLVNSKGSDT ASCHVTVVDR PGPPQGPLNA
YDITPDTCTL AWKTPLDDGG SPITNYVVEK LDTSGTWVKV SSFVRNTHYD VMGLEPNHKY
HFRVRAENQY GLSDPLEIPE PITAKHQFTV PDEPGQPKVI DWDSGNVTLI WTRPASDGGS
RIQGYQIEYR DIVNDSSWNT YEYLIKDTKY QLYNLTNGSE YEFRIKAKNA AGFSKPSPPS
LRFKLKGKFN VPAPPGTPQV TKVGKNYVDL KWEKPISDGG SRITGYIIER RDIGGAVWVK
CNDYNVLDTE FTVINLIEMG DYEFRIFAIN AAGRSEPSLC TMPIKVCEVL GGEKPDWISR
LQDRIAPSGK DFTLQCAASG KPSPTARWLR NGKEIQMQPG GRFICDSKDG VFRLHISNVQ
SGDDGDYTCE AINSLGFVHT SGYLKVGSPP IINRCPSELY LPESDNTKIK VYYSGDQPLS
VKITKNNELI SDGADESHFK YTIFDEYIAI FIRDIIKSDA GNYQIELSND SGSATGHFDA
YITGLPSAPV GPMGISHINK HSCTLAWRPP ANVGGLRITH YVVERKDITS PHWITVSSSC
KDTSFNVQGL LENQEYIFRV MAVNENGIGA PLEGLNPIRA KAPIDPPSPP GIPEITEIGG
DFVHLEWAKP ESDGGAHIQG YWVDKREVGS DTWQRVNPII NAANQINCHN LIEGRQYEFR
IFAQNIAGLS KESTASQVVK IVDPKAATAP IIVKSLRDAN CIQNHNAQFT CTITGVPRPT
ITWYKGAREI TSGARYYIYS EGDNHFLNIN DVFGEDADEY VCRAVNKAGA KSTRAALAIM
TAPKLNVPPR FRDTAYFDKG ENVVIKIPFT GFPKPRIHWV REGENIESGG HYNVEVKERH
AVLTIRDGSR LDSGPYRITA ENELGSDTAI IQVQISDRPD PPRFPVVESI GTDSLSLSWK
APIWDGGSDI TNYYVERREH PLSSWIRVGN TRFTSMAVTG LTPGKEYDFR VFADNVYGRS
DASDISTLIK TKESIKKKPV ERKWELDESG KRIRGKADGP IKDYDSYVFD IFSKFVPQPV
EISHESVYNR YDILEEIGNG AFGVVHRCRE RSTGNIFAAK FIPVSHAVEK DLIRREIDIM
NQLHHQKLIN LHDAFEDDDE MVLILEFLSG GELFERITAE GYVMTEAEVI NYMRQICEGI
RHMHEKNIIH LDIKPENIMC QTRTSTNVKL IDFGLATRLD PNEVVKITTG TAEFAAPEIV
NREPVGFYTD MWATGVLAYV LLSGLSPFAG DNDVQTLKNV KACDWDFDLE AFKHISDEGK
DFIRKLLIAS KEKRMTAHEC LLHPWLTGDH RELNQKIARD RYLAYREKLR KKYEDFGKYL
LPIGRLAEYS SLRKLLMEKY KMHDAVFDRR QAAPRFVIRP SSQFCYEGQS VKFYCRCIAI
ATPTLTWSHN NIELRQSVKF MKRYAGDDYY FIINRVKLDD RGEYIIRAEN HYGSREEVVF
LNVHPLPKEQ PKYRTESTPV RRREPLPYTL WQEESESAPS FTFLLRPRVM QARDTCKLLC
CLSGKPVPTV KWYKDGRELS KYEYAMTHSD GVVTMEIIDC KPSDSGKYTC KATNCHGTDE
TSCVVIVEGE WVTPEQAELA HNFLYSGDRK YIEQHFKPTP PPIITTRQFT SSATSSNSQQ
TSSTRTTSDG KTVITNSSSS TQNSISSKKK YAASSLQAPG SPSRSRSATK ELILPPDDSL
MCKPEFTKPL HDLTISDGEQ LLLTCHVKGD PEPQITWSKN GKSISSSEIM DLKYKNGIAT
LTIHEVFPED EGVFSCTATN SISSVETKCK LTIKPLDKQS SKRLPTGSDK PPKIVSHLES
RFVKDGDAVT LACRIIGADH FDVVWLHNNK EIKPSKDFQY SNEANIYRLQ IAEIFPEDGG
TYTCEAFNDA GESFSTCTIN VNVPGDEPKV PTFVKFPVSV SVTEGENATF ECESDGELIN
LAWLKDGKPI DEARARYSFT KDSNRYKFSV NKCTLDDVGQ YQARAVSKKG ESLCAFSVNV
LSSEA
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