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Database: UniProt
Entry: A0A0Q9WLX4_DROVI
LinkDB: A0A0Q9WLX4_DROVI
Original site: A0A0Q9WLX4_DROVI 
ID   A0A0Q9WLX4_DROVI        Unreviewed;      2141 AA.
AC   A0A0Q9WLX4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|FlyBase:FBgn0015214};
GN   Synonyms=Dvir\para {ECO:0000313|EMBL:KRF82111.1};
GN   ORFNames=Dvir_GJ19029 {ECO:0000313|EMBL:KRF82111.1}, GJ19029
GN   {ECO:0000313|FlyBase:FBgn0015214};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF82111.1, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:KRF82111.1, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH940651; KRF82111.1; -; Genomic_DNA.
DR   RefSeq; XP_015026533.1; XM_015171047.1.
DR   GeneID; 6631799; -.
DR   FlyBase; FBgn0015214; Dvir\para.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    160       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    204    226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    238    256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    262    284       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    394    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    799    822       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    843    860       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    872    896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    927    949       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    969    986       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1007   1028       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1315   1333       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1354   1376       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1382   1408       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1429   1460       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1547   1573       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1636   1654       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1666   1685       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1697   1716       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1760   1783       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1846   1869       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1890   1925       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      420    455       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2141 AA;  240675 MW;  CF564BC7F7289DE0 CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEI RYDDEDEDEG
     PQPDPTLEQG VPIPVRLQGS FPPELASTPL EDIDPYYSNI LTFVVVSKGK DIFRFSASKA
     MWLLDPFNPI RRVAIYILVH PLFSLFIITT ILVNCILMIM PTTPTVESTE VIFTGIYTFE
     SAVKVMARGF ILCPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA
     IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KKFPLDGSWG
     NLTDENWDYH NRNSSNWYSE DDGISFPLCG NISGAGQCDD DYVCLQGFGP NPNYGYTSFD
     SFGWAFLSAF RLMTQDFWED LYQLVLRAAG PWHMLFFIVI IFLGSFYLVN LILAIVAMSY
     DELQKKAEEE EAAEEEAIRE AEEAAAAKAA KLEERANAHA QAAADAAAAE EAALHPEMAK
     SPTYSCISYE LFVGGEKGND DNNKEKMSIR SVEVESESVS VIQRQPAPTT AHQATKVRKV
     STTSLSLPGS PFNIRRGSRS SHKYTIRNGR GRFGIPGSDR KPLVLSTYQD AQQHLPYADD
     SNAVTPMSEE NGAIIVPVYY GNLGSRHSSY TSHQSRISYT SHGDLLGGMA VMGVSTMTKE
     SKLRNRNTRN QSVGATNGGT TCLDTNHKVE HRDYEIGLEC TDEAGKIKHH DNPFIEPVQT
     QTVVDMKDVM VLNDIIEQAA GRHSRASDRG VSVYYFPTED DDEDGPTLKD RALEVILKGI
     DVFCVWDCCW VWLKFQEWVS LIVFDPFVEL FITLCIVVNT MFMAMDHHDM NKEMERVLKA
     GNYFFTATFA IEATMKLMAM SPKYYFQEGW NIFDFIIVAL SLLELGLEGV QGLSVLRSFR
     LLRVFKLAKS WPTLNLLISI MGRTVGALGN LTFVLCIIIF IFAVMGMQLF GKNYTDHKDR
     FPDGDLPRWN FTDFMHSFMI VFRVLCGEWI ESMWDCMYVG DVSCIPFFLA TVVIGNLVVL
     NLFLALLLSN FGSSSLSAPT ADNDTNKIAE AFNRIGRFKS WVKRNVADCF KLIRNKLTNQ
     ISDQPSGERI NQISWIWSEG KGVCRCISAE HGDNELELGH DEILADGLIK KGIKEQTQLE
     VAIGDGMEFT IHGDMKNNKP KKSKYLNNAT MIGNSINHQD NRLEHELNHR GLSLQDDDTA
     SINSYGSHKN RPFKDESHKG SAETMEGEEK RDASKEDLGL DEELDEEGEC EEGPLDGDII
     IHANDEDILD EYPADCCPDS YYKKFPILAG DEDSPFWQGW GNLRLKTFQL IENKYFETAV
     ITMILMSSLA LALEDVHLPQ RPILQDILYY MDRIFTVIFF LEMLIKWLAL GFKVYFTNAW
     CWLDFVIVMV SLINFVASLV GAGGIQAFKT MRTLRALRPL RAMSRMQGMR VVVNALVQAI
     PSIFNVLLVC LIFWLIFAIM GVQLFAGKYF KCEDLNGTKL SHEIIPNRNA CESENYTWVN
     SAMNFDHVGN AYLCLFQVAT FKGWIQIMND AIDSREVDKQ PIRETNIYMY LYFVFFIIFG
     SFFTLNLFIG VIIDNFNEQK KKAGGSLEMF MTEDQKKYYN AMKKMGSKKP LKAIPRPRWR
     PQAIVFEIVT DKKFDIIIML FIGLNMFTMT LDRYDASDTY NAVLDYLNAI FVVIFSSECL
     LKIFALRYHY FIEPWNLFDV VVVILSILGL VLSDIIEKYF VSPTLLRVVR VAKVGRVLRL
     VKGAKGIRTL LFALAMSLPA LFNICLLLFL VMFIFAIFGM SFFMHVKEKS GINDVYNFKT
     FGQSMILLFQ MSTSAGWDGV LDAIINEEAC DPPDNDKGYP GNCGSATVGI TFLLSYLVIS
     FLIVINMYIA VILENYSQAT EDVQEGLTDD DYDMYYEIWQ QFDPEGTQYI RYDQLSEFLD
     VLEPPLQIHK PNKYKIISMD IPICRGDLMY CVDILDALTK DFFARKGNPI EETGEIGEIA
     ARPDTEGYEP VSSTLWRQRE EYCARLIQHA WRKHKTRAEA GGGDPDADAA NDMDPDPAAG
     DDAPDDNAAA DDDPDAAGAN GGHDPAADGA AVDPANDPKS IVNSPMDGGG GSPGGQSAGS
     GGSAGRQTAV LVESDGFVTK NGHKVVIHSR SPSITSRTAD V
//
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