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Database: UniProt
Entry: A0A0Q9WLZ8_DROVI
LinkDB: A0A0Q9WLZ8_DROVI
Original site: A0A0Q9WLZ8_DROVI 
ID   A0A0Q9WLZ8_DROVI        Unreviewed;      2107 AA.
AC   A0A0Q9WLZ8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   28-MAR-2018, entry version 17.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|FlyBase:FBgn0015214};
GN   Synonyms=Dvir\para {ECO:0000313|EMBL:KRF82084.1};
GN   ORFNames=Dvir_GJ19029 {ECO:0000313|EMBL:KRF82084.1}, GJ19029
GN   {ECO:0000313|FlyBase:FBgn0015214};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF82084.1, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:KRF82084.1, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH940651; KRF82084.1; -; Genomic_DNA.
DR   RefSeq; XP_015026552.1; XM_015171066.1.
DR   EnsemblMetazoa; FBtr0433807; FBpp0390919; FBgn0015214.
DR   GeneID; 6631799; -.
DR   FlyBase; FBgn0015214; Dvir\para.
DR   ChiTaRS; Prm; fly.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    134    161       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    205    227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    239    257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    285       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    395    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    800    823       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    844    861       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    873    897       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    928    950       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1008   1029       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1320   1342       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1348   1374       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1395   1426       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1513   1539       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1602   1620       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1632   1651       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1663   1682       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1726   1749       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1812   1835       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1856   1891       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       24     44       {ECO:0000256|SAM:Coils}.
FT   COILED      421    456       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2107 AA;  236958 MW;  7620D8328479AC6C CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV IRYDDEDEDE
     GPQPDPTLEQ GVPIPVRLQG SFPPELASTP LEDIDPYYSN ILTFVVVSKG KDIFRFSASK
     AMWLLDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTVEST EVIFTGIYTF
     ESAVKVMARG FILCPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT FRVLRALKTV
     AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC IKKFPLDGSW
     GNLTDENWDY HNRNSSNWYS EDDGISFPLC GNISGAGQCD DDYVCLQGFG PNPNYGYTSF
     DSFGWAFLSA FRLMTQDFWE DLYQLVLRAA GPWHMLFFIV IIFLGSFYLV NLILAIVAMS
     YDELQKKAEE EEAAEEEAIR EAEEAAAAKA AKLEERANAH AQAAADAAAA EEAALHPEMA
     KSPTYSCISY ELFVGGEKGN DDNNKEKMSI RSVEVESESV SVIQRQPAPT TAHQATKVRK
     VSTTSLSLPG SPFNIRRGSR SSHKYTIRNG RGRFGIPGSD RKPLVLSTYQ DAQQHLPYAD
     DSNAVTPMSE ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM AVMGVSTMTK
     ESKLRNRNTR NQSVGATNGG TTCLDTNHKV EHRDYEIGLE CTDEAGKIKH HDNPFIEPVQ
     TQTVVDMKDV MVLNDIIEQA AGRHSRASDR GVSVYYFPTE DDDEDGPTLK DRALEVILKG
     IDVFCVWDCC WVWLKFQEWV SLIVFDPFVE LFITLCIVVN TMFMAMDHHD MNKEMERVLK
     AGNYFFTATF AIEATMKLMA MSPKYYFQEG WNIFDFIIVA LSLLELGLEG VQGLSVLRSF
     RLLRVFKLAK SWPTLNLLIS IMGRTMGALG NLTFVLCIII FIFAVMGMQL FGKNYHDHKD
     RFPDGDLPRW NFTDFMHSFM IVFRVLCGEW IESMWDCMYV GDVSCIPFFL ATVVIGNLVV
     LNLFLALLLS NFGSSSLSAP TADNDTNKIA EAFNRIGRFK SWVKRNVADC FKLIRNKLTN
     QISDQPSGER INQISWIWSE EHGDNELELG HDEILADGLI KKGIKEQTQL EVAIGDGMEF
     TIHGDMKNNK PKKSKYLNNA TDDDTASINS YGSHKNRPFK DESHKGSAET MEGEEKRDAS
     KEDLGLDEEL DEEGECEEGP LDGDIIIHAN DEDILDEYPA DCCPDSYYKK FPILAGDEDS
     PFWQGWGNLR LKTFQLIENK YFETAVITMI LMSSLALALE DVHLPQRPIL QDILYYMDRI
     FTVIFFLEML IKWLALGFKV YFTNAWCWLD FVIVMVSLIN FVASLVGAGG IQAFKTMRTL
     RALRPLRAMS RMQGMRVVVN ALVQAIPSIF NVLLVCLIFW LIFAIMGVQL FAGKYFKCED
     LNGTKLSHEI IPNRNACESE NYTWVNSAMN FDHVGNAYLC LFQVATFKGW IQIMNDAIDS
     REVDKQPIRE TNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED
     QKKYYNAMKK MGSKKPLKAI PRPRWRPQAI VFEIVTDKKF DIIIMLFIGL NMFTMTLDRY
     DASDTYNAVL DYLNAIFVVI FSSECLLKIF ALRYHYFIEP WNLFDVVVVI LSILGLVLSD
     IIEKYFVSPT LLRVVRVAKV GRVLRLVKGA KGIRTLLFAL AMSLPALFNI CLLLFLVMFI
     FAIFGMSFFM HVKEKSGIND VYNFKTFGQS MILLFQMSTS AGWDGVLDAI INEEACDPPD
     NDKGYPGNCG SATVGITFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM
     YYEIWQQFDP EGTQYIRYDQ LSEFLDVLEP PLQIHKPNKY KIISMDIPIC RGDLMYCVDI
     LDALTKDFFA RKGNPIEETG EIGEIAARPD TEGYEPVSST LWRQREEYCA RLIQHAWRKH
     KTRAEAGGGD PDADAANDMD PDPAAGDDAP DDNAAADDDP DAAGANGGHD PAADGAAVDP
     ANDPKSIVNS PMDGGGGSPG GQSAGSGGSA GRQTAVLVES DGFVTKNGHK VVIHSRSPSI
     TSRTADV
//
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