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Database: UniProt
Entry: A0A0Q9WP45_DROVI
LinkDB: A0A0Q9WP45_DROVI
Original site: A0A0Q9WP45_DROVI 
ID   A0A0Q9WP45_DROVI        Unreviewed;      2130 AA.
AC   A0A0Q9WP45;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   05-JUL-2017, entry version 14.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|FlyBase:FBgn0015214};
GN   Synonyms=Dvir\para {ECO:0000313|EMBL:KRF82096.1};
GN   ORFNames=Dvir_GJ19029 {ECO:0000313|EMBL:KRF82096.1}, GJ19029
GN   {ECO:0000313|FlyBase:FBgn0015214};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF82096.1, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:KRF82096.1, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH940651; KRF82096.1; -; Genomic_DNA.
DR   RefSeq; XP_015026518.1; XM_015171032.1.
DR   STRING; 7244.FBpp0233446; -.
DR   GeneID; 6631799; -.
DR   FlyBase; FBgn0015214; Dvir\para.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    145    172       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    216    238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    274    296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    811    834       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    855    872       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    884    908       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    939    961       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1019   1040       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1343   1365       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1371   1397       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1418   1449       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1536   1562       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1625   1643       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1655   1674       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1686   1705       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1749   1772       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1835   1858       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1879   1914       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      432    467       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2130 AA;  239638 MW;  BA1B6EB79541A60B CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV PQYGRKKKQK
     EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST PLEDIDPYYS NILTFVVVSK
     GKDIFRFSAS KAMWLLDPFN PIRRVAIYIL VHPLFSLFII TTILVNCILM IMPTTPTVES
     TEVIFTGIYT FESAVKVMAR GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR
     TFRVLRALKT VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK
     CIKKFPLDGS WGNLTDENWD YHNRNSSNWY SEDDGISFPL CGNISGAGQC DDDYVCLQGF
     GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA AGPWHMLFFI VIIFLGSFYL
     VNLILAIVAM SYDELQKKAE EEEAAEEEAI REAEEAAAAK AAKLEERANA HAQAAADAAA
     AEEAALHPEM AKSPTYSCIS YELFVGGEKG NDDNNKEKMS IRSVEVESES VSVIQRQPAP
     TTAHQATKVR KVSTTSLSLP GSPFNIRRGS RSSHKYTIRN GRGRFGIPGS DRKPLVLSTY
     QDAQQHLPYA DDSNAVTPMS EENGAIIVPV YYGNLGSRHS SYTSHQSRIS YTSHGDLLGG
     MAVMGVSTMT KESKLRNRNT RNQSVGATNG GTTCLDTNHK VEHRDYEIGL ECTDEAGKIK
     HHDNPFIEPV QTQTVVDMKD VMVLNDIIEQ AAGRHSRASD RGVSVYYFPT EDDDEDGPTL
     KDRALEVILK GIDVFCVWDC CWVWLKFQEW VSLIVFDPFV ELFITLCIVV NTMFMAMDHH
     DMNKEMERVL KAGNYFFTAT FAIEATMKLM AMSPKYYFQE GWNIFDFIIV ALSLLELGLE
     GVQGLSVLRS FRLLRVFKLA KSWPTLNLLI SIMGRTMGAL GNLTFVLCII IFIFAVMGMQ
     LFGKNYHDHK DRFPDGDLPR WNFTDFMHSF MIVFRVLCGE WIESMWDCMY VGDVSCIPFF
     LATVVIGNLV VLNLFLALLL SNFGSSSLSA PTADNDTNKI AEAFNRIGRF KSWVKRNVAD
     CFKLIRNKLT NQISDQPSEH GDNELELGHD EILADGLIKK GIKEQTQLEV AIGDGMEFTI
     HGDMKNNKPK KSKYLNNATM IGNSINHQDN RLEHELNHRG LSLQDDDTAS INSYGSHKNR
     PFKDESHKGS AETMEGEEKR DASKEDLGLD EELDEEGECE EGPLDGDIII HANDEDILDE
     YPADCCPDSY YKKFPILAGD EDSPFWQGWG NLRLKTFQLI ENKYFETAVI TMILMSSLAL
     ALEDVHLPQR PILQDILYYM DRIFTVIFFL EMLIKWLALG FKVYFTNAWC WLDFVIVMVS
     LINFVASLVG AGGIQAFKTM RTLRALRPLR AMSRMQGMRV VVNALVQAIP SIFNVLLVCL
     IFWLIFAIMG VQLFAGKYFK CEDLNGTKLS HEIIPNRNAC ESENYTWVNS AMNFDHVGNA
     YLCLFQVATF KGWIQIMNDA IDSREVDKQP IRETNIYMYL YFVFFIIFGS FFTLNLFIGV
     IIDNFNEQKK KAGGSLEMFM TEDQKKYYNA MKKMGSKKPL KAIPRPRWRP QAIVFEIVTD
     KKFDIIIMLF IGLNMFTMTL DRYDASDTYN AVLDYLNAIF VVIFSSECLL KIFALRYHYF
     IEPWNLFDVV VVILSILGLV LSDIIEKYFV SPTLLRVVRV AKVGRVLRLV KGAKGIRTLL
     FALAMSLPAL FNICLLLFLV MFIFAIFGMS FFMHVKEKSG INDVYNFKTF GQSMILLFQM
     STSAGWDGVL DAIINEEACD PPDNDKGYPG NCGSATVGIT FLLSYLVISF LIVINMYIAV
     ILENYSQATE DVQEGLTDDD YDMYYEIWQQ FDPEGTQYIR YDQLSEFLDV LEPPLQIHKP
     NKYKIISMDI PICRGDLMYC VDILDALTKD FFARKGNPIE ETGEIGEIAA RPDTEGYEPV
     SSTLWRQREE YCARLIQHAW RKHKTRAEAG GGDPDADAAN DMDPDPAAGD DAPDDNAAAD
     DDPDAAGANG GHDPAADGAA VDPANDPKSI VNSPMDGGGG SPGGQSAGSG GSAGRQTAVL
     VESDGFVTKN GHKVVIHSRS PSITSRTADV
//
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