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Database: UniProt
Entry: A0A0Q9WXM0_DROMO
LinkDB: A0A0Q9WXM0_DROMO
Original site: A0A0Q9WXM0_DROMO 
ID   A0A0Q9WXM0_DROMO        Unreviewed;      1174 AA.
AC   A0A0Q9WXM0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 11.
DE   SubName: Full=Slowpoke, isoform N {ECO:0000313|EMBL:KRG00768.1};
GN   Name=slo {ECO:0000313|FlyBase:FBgn0146742};
GN   Synonyms=Dmoj\slo {ECO:0000313|EMBL:KRG00768.1};
GN   ORFNames=Dmoj_GI24019 {ECO:0000313|EMBL:KRG00768.1}, GI24019
GN   {ECO:0000313|FlyBase:FBgn0146742};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG00768.1, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:KRG00768.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; CH933806; KRG00768.1; -; Genomic_DNA.
DR   RefSeq; XP_015021874.1; XM_015166388.1.
DR   GeneID; 6572415; -.
DR   FlyBase; FBgn0146742; Dmoj\slo.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF37; PTHR10027:SF37; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     48     72       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    190    213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    249    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    285    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    336       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      130    339       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1174 AA;  130267 MW;  2F00D1AB9EA2A5F9 CRC64;
     MASGLIGTNI SELTNGMSGC DQSTVESLAD DPTDSPFDAD DCLKVRKYWC FLLSSIFTFL
     AGLLIVLLWR AFAFICCRKE PDLGPNDPKQ KEQKASRNKQ EFEGTFMTEA KDWAGELISG
     QTTTGRILVV LVFILSIASL IIYFVDASSE EVERCQKWSN NITQQIDLAF NIFFMVYFFI
     RFIAASDKLW FMLEMYSFVD YFTIPPSFVS IYLDRTWIGL RFLRALRLMT VPDILQYLNV
     LKTSSSIRLA QLVSIFISVW LTAAGIIHLL ENSGDPLDFN NAHRLSYWTC VYFLIVTMST
     VGYGDVYCET VLGRTFLVFF LLVGLAIFAS CIPEIIDLIG TRAKYGGTLK NEKGRRHIVV
     CGHITYESVS HFLKDFLHED REDVDVEVVF LHRKPPDLEL EGLFKRHFTT VEFFQGTIMN
     PIDLQRVKVH EADACLVLAN KYCQDPDAED AANIMRVISI KNYSDDIRVI IQLMQYHNKA
     YLLNIPSWDW KQGDDVICLA ELKLGFIAQS CLAPGFSTMM ANLFAMRSFK TSPEMQSWTN
     DYLRGTGMEM YTETLSPTFI GIPFAQATEL CFSKLKLLLL AIEIKGAEEG ADSKISINPR
     GAKIQANTQG FFIAQSADEV KRAWFYCKAC HEDIKDETLI KKCKCKNLTV QPRSKFDDLG
     DITRDREDTN LLNRNVRRPN GTGNGTGGMH HMNNTAAAAA AAAAAGKQVN KVKPTVNVSR
     QVEGQVISPS QYNRPTSRSS GTGTQNQNGG VSLPAGIADD QSKDFDFEKT EMKYDSTGMF
     HWSPAKSLED CILDRNQAAM TVLNGHVVVC LFADPDSPLI GLRNLVMPLR ASNFHYHELK
     HVVIVGSVDY IRREWKMLQN LPKISVLNGS PLSRADLRAV NVNLCDMCCI LSAKVPSNDD
     PTLADKEAIL ASLNIKAMTF DDTIGVLSQR GPEFDNLSAT AGSPIVLQRR GSVYGANVPM
     ITELVNDSNV QFLDQDDDDD PDTELYLTQP FACGTAFAVS VLDSLMSTTY FNQNALTLIR
     SLITGGATPE LELILAEGAG LRGGYSTIDS LSNRDRCRVG QISLYDGPLA QFGECGKYGD
     LFVAALKSYG MLCIGLYRFR DTSSSCDASS KRYVITNPPD DFSLLPTDQV FVLMQFDPGL
     EYKPPAVRAP AGGRGTNTQG SGVGGGGSNK DDNS
//
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