ID A0A0Q9X0S0_DROMO Unreviewed; 2868 AA.
AC A0A0Q9X0S0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Uncharacterized protein, isoform D {ECO:0000313|EMBL:KRG01493.1};
DE EC=3.4.24.- {ECO:0000313|EMBL:KRG01493.1};
GN Name=Dmoj\GI22868 {ECO:0000313|EMBL:KRG01493.1};
GN ORFNames=Dmoj_GI22868 {ECO:0000313|EMBL:KRG01493.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG01493.1, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:KRG01493.1, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH933806; KRG01493.1; -; Genomic_DNA.
DR RefSeq; XP_015022599.1; XM_015167113.1.
DR EnsemblMetazoa; FBtr0429376; FBpp0386840; FBgn0145595.
DR GeneID; 6573763; -.
DR OrthoDB; 2910701at2759; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd00109; Kunitz-type; 6.
DR CDD; cd22639; Kunitz_papilin_lacunin-like; 1.
DR CDD; cd22637; Kunitz_papilin_mig6-like; 2.
DR CDD; cd00199; WAP; 1.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 10.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR008197; WAP_dom.
DR PANTHER; PTHR45938; ACP24A4-RELATED; 1.
DR PANTHER; PTHR45938:SF11; PAPILIN; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00014; Kunitz_BPTI; 10.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 5.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00131; KU; 10.
DR SMART; SM00209; TSP1; 7.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57362; BPTI-like; 10.
DR SUPFAM; SSF57256; Elafin-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 7.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 6.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 10.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
DR PROSITE; PS51390; WAP; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3}; Hydrolase {ECO:0000313|EMBL:KRG01493.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..2868
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006387328"
FT DOMAIN 1699..1749
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1758..1808
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1817..1867
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1877..1927
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1936..1986
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2005..2055
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2081..2131
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2148..2198
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2205..2255
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2276..2326
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2415..2461
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 2471..2570
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2580..2668
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2721..2812
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2819..2858
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 700..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2055..2083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..739
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 69..105
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 73..110
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 84..95
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 2868 AA; 306493 MW; 265B7468109F44DE CRC64;
MDLSRRLRIT ALIAFILIIC VPDSQSRFPG LRAKRQYGAN LYLPASYVIP GGEGDDPSEW
TDWSSPSECS RTCGGGVSYQ TRECRRRDAN GDDMCSGGSR RYYSCNTQDC PEEEPDFRAM
QCSRFDYTKF DGVLYTWVPY TNAANPCELN CMPKGERFYY RQKEMVVDGT RCNDKDLDVC
VNGQCLPVGC DMMLGSDAKE DKCRKCGGDG STCKTIKNIY ASSDLSAGYN DLLLVPQGAT
NIRIQETAPS NNYLACRNQS GHYYLNGNWR IDFPRPMFYA GAWWNYERKP LGFAAPDQLT
CSGPITESIY IIMLVQDKNV SVEYEYSIPE SLSHSQPDAH TWTHREFGPC SASCGGGTQS
RQVTCNNRIN LQEVDEALCE AHTKPAETQA CGTEPCAPHW VEGVWGKCSK GCGSDGFQNR
TVTCERISSD GVHTAEDDAV CLKEVGNKPA TAQECNRDVK NCPKYHLGPW KPCDKLCGEG
KQTRKVTCFI EENGHKRVLP EEDCVEDKPE VERACLLAPC EGVDWIISQW SGCDACGQTT
ETRTAVCGSK DGKVYPDKFC GDKAPELTRS CTSSKCESQW FSSEWSKCSA ACGKGAQSRI
VLCGIFDGKQ IKTTDDSKCD AATKPKTDQE CEGEEKECPG QWFTGPFGQC SKPCGGGERV
REVLCLSNGT KSLNCDESKV ESISEKCNTQ PCTKDQVLPL TSTDKPIEDD EEECEDDDEF
VLVDSDVTDV TDDDSEAMST TDDLMLSDSP YTTSEDASAS TDSTVEGSGS DSTSDSGFEG
SGSESTSEVS TSSDESSTGA TDWSTESSGS SAISESTSEA SSSSVSGVTS DSSTSEASSG
STDVSGSTEE SSLGTTDASS SDASSSTEVS GSTEISSATE VSGTTDISSS TDASSSTDVS
GSTEVSSSTD ASGSTDISSS TEASSSTDAS GSTDASSSTD ASSSTDISSA TDSSGSTDGS
SSGFTDLPLE ASSSGSSESS SSTEGVSSTS ESSSDATKDT TEVSSSTDTS SSTESSVSTD
TTVSSSTEST SELSTESTES TSSPGSTEST TEGSSSASAD SSSSGITEST SSGSTDSTKQ
DSTDESTTNA SSSSADGSTD STTEGVSTGS TDGLTETSTD GSTDNLSSGS TDGSSGGSTD
GSTDVTTDSS TDSSSNGSTD TTNASESTES QSTGVTESTS EGSSSGSTIE GSSSSTDSSS
STDSSASTDI SGSTDSSTIG STESSATTDS STDVSSTDIS SSESSDSTAT TESGATTESG
GTTESGGTTD TTSESSTDST GSTDSTGSSL STETSSTSDI WSTSDSDDET STPHTWETTL
TPKKDKLRKC KSKKKSCAKT EFGCCPDGKS TAKGPFDEGC PIAKTCADTE FGCCSDGVSP
AKGKRNKGCP KSNCAETLFG CCPDKYTAAE GEDNEGCPEP TTLPPTTTEE STISISTDVE
GSGDSNSSTE SDTAVTSCSF TEFYCCPDGK TPAKGENFAG CPQLGGAPGC EQSEHGCCPD
RRTAAAGPDG QGCAACTSEP FGCCPDNETP AHGPQGEGCC LNTEFGCCPD NIRPAYGPNF
EGCECASSPY GCCADQKTSA RGPQQEGCPC ETTPYGCCPD KITAARGPKF EGCPCESMQF
GCCPDGLSFA KGPHNQGCHC AQTEFKCCED GKTPAKGPNF EGCTCVETEY GCCPDGVTKA
QDDKFGGCEN VQEPPQKACG LPKEQGTCGN FSVKYYFDTS YGGCARFWYG GCEGNGNRFE
TEADCKDTCQ EYTGQHVCLL PKSSGPCQGY SKKWYFDTDR NRCEEFQYGG CYGTNNRFDS
LEQCQSTCAI SETLPACEQP VESGPCAGNY ERWYYDNQTD VCRPFTYGGC KGNKNNYPTE
HACIYSCRQP GVLKEQCSLP KQTGDCSEKH ARWQFSETEK RCVPFYYSGC GGNKNNFPTL
ESCEDHCPRQ VAKDICDIPA EVGECANYVF AWYYDTKDAA CRQFYYGGCG GNENRFTSEE
ACMARCEKKP EPPTPPPPQS AVHVCDQPEE RGDCDNYSLK WSFDRSSGAC RQFYYGGCGG
NGNRFETESD CLQRCGRQPE PERQPQPEPQ PQQPQPSGSL CEQPASVGDC AEYVLKWSYN
STLGSCQQFY YGGCGGNENR FETEEDCSAR CIAGIDEEPR PGSETDKCFR GPEPGNCYEN
ITRWYYNSQE GLCDEFVYSG CGGNDNNFDT EEDCQNDCHP AQETCSLPPV AGRCNDNSNR
WYFDGRTGAC HQFVFTGCRG NRNNFVTEQS CLEYCRRDQP HPEPEPEPPA PSYSVCTQPA
EAGECDNHTT AWFYDNEKML CTAFIYSGCG GNGNRFETRD QCERQCGEFK GVEPIDNEIV
NEISPSRCET YDNECRDLRC PYGVRRVPAE SQPECEQCIC LNPCEGYPCP DGQQCAIDVS
NSGGRDNQFV PVCRDIIKPG LCPQLTANAS ECARECYTDA DCRGDNKCCS DGCGHLCVAP
ARPTRRPSTP PPVVIYPGEV KATLESKAPQ DVDVHTSVGG IAVLRCFATG NPAPNITWSL
KNVVIDTNQG RYVLTSNGDL TIVQVRQTDD GTYVCVASNG LGEPVRREVA LQVTEARDVP
AYILGVKNVT QIVQLNQPAL VRCPAGGYPA PHVSWWRNNQ HFGMGPETSR AVMNRDYSLY
FRSVQLSDLG LYTCDAYNTG RPVSLHVTLK AIGPAIAQSA GDDKYLQYII NPPKAPVTQR
PTYPYRPSRP VYVPPPVVHD PRIDARAVIG LNPQNKYTPG STIAMDCAVQ GNPAPNVTWT
KDNTPLYNND RVQITANPHR LVVSDVTTED SGIYGCTARN AYSYSTSQET VTIESVVPLS
PECIDNPYFA NCKLIIQGHY CVNKYYAQFC CRSCTLAGQI SQPHPNAL
//
