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Database: UniProt
Entry: A0A0Q9X4A7_DROMO
LinkDB: A0A0Q9X4A7_DROMO
Original site: A0A0Q9X4A7_DROMO 
ID   A0A0Q9X4A7_DROMO        Unreviewed;      1196 AA.
AC   A0A0Q9X4A7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 11.
DE   SubName: Full=Slowpoke, isoform H {ECO:0000313|EMBL:KRG00762.1};
GN   Name=slo {ECO:0000313|FlyBase:FBgn0146742};
GN   Synonyms=Dmoj\slo {ECO:0000313|EMBL:KRG00762.1};
GN   ORFNames=Dmoj_GI24019 {ECO:0000313|EMBL:KRG00762.1}, GI24019
GN   {ECO:0000313|FlyBase:FBgn0146742};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG00762.1, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:KRG00762.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; CH933806; KRG00762.1; -; Genomic_DNA.
DR   RefSeq; XP_015021868.1; XM_015166382.1.
DR   GeneID; 6572415; -.
DR   FlyBase; FBgn0146742; Dmoj\slo.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF37; PTHR10027:SF37; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     48     72       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    190    213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    249    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    285    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    311    329       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      130    338       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1196 AA;  132744 MW;  3A9701184C0956B9 CRC64;
     MASGLIGTNI SELTNGMSGC DQSTVESLAD DPTDSPFDAD DCLKVRKYWC FLLSSIFTFL
     AGLLIVLLWR AFAFICCRKE PDLGPNDPKQ KEQKASRNKQ EFEGTFMTEA KDWAGELISG
     QTTTGRILVV LVFILSIASL IIYFVDASSE EVERCQKWSN NITQQIDLAF NIFFMVYFFI
     RFIAASDKLW FMLEMYSFVD YFTIPPSFVS IYLDRTWIGL RFLRALRLMT VPDILQYLNV
     LKTSSSIRLA QLVSIFISVW LTAAGIIHLL ENSGDPLDFN NAHRLSYWTC VYFLIVTMST
     VGYGDVYCET VLGRTFLVFF LLVGLAMFAS SIPEIIELVG SGNKYGGELK REHGKRHIVV
     CGHITYESVS HFLKDFLHED REDVDVEVVF LHRKPPDLEL EGLFKRHFTT VEFFQGTIMN
     PIDLQRVKVH EADACLVLAN KYCQDPDAED AANIMRVISI KNYSDDIRVI IQLMQYHNKA
     YLLNIPSWDW KQGDDVICLA ELKLGFIAQS CLAPGFSTMM ANLFAMRSFK TSPEMQSWTN
     DYLRGTGMEM YTETLSPTFI GIPFAQATEL CFSKLKLLLL AIEIKGAEEG ADSKISINPR
     GAKIQANTQG FFIAQSADEV KRAWFYCKAC HEDIKDETLI KKCKCKNLTV QPRSKFDDLG
     DITRDREDTN LLNRNVRRPN GTGNGTGGMH HMNNTAAAAA AAAAAGKQVN KVKPTVNVSR
     QVEGQVISPS QYNRPPENDA NPYAGYQLAY EVKKLMPTSR SSGTGTQNQN GGVSLPAGIA
     DDQSKDFDFE KTEMKYDSTG MFHWSPAKSL EDCILDRNQA AMTVLNGHVV VCLFADPDSP
     LIGLRNLVMP LRASNFHYHE LKHVVIVGSV DYIRREWKML QNLPKISVLN GSPLSRADLR
     AVNVNLCDMC CILSAKVPSN DDPTLADKEA ILASLNIKAM TFDDTIGVLS QRGPEFDNLS
     ATAGSPIVLQ RRGSVYGANV PMITELVNDS NVQFLDQDDD DDPDTELYLT QPFACGTAFA
     VSVLDSLMST TYFNQNALTL IRSLITGGAT PELELILAEG AGLRGGYSTI DSLSNRDRCR
     VGQISLYDGP LAQFGECGKY GDLFVAALKS YGMLCIGLYR FRDTSSSCDA SSKRYVITNP
     PDDFSLLPTD QVFVLMQFDP GLEYKPPAVR APAGGRGTNT QGSGVGGGGS NKDDNS
//
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