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Database: UniProt
Entry: A0A0Q9XF06_DROMO
LinkDB: A0A0Q9XF06_DROMO
Original site: A0A0Q9XF06_DROMO 
ID   A0A0Q9XF06_DROMO        Unreviewed;      2143 AA.
AC   A0A0Q9XF06;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dmoj\GI21488 {ECO:0000313|EMBL:KRG06973.1};
GN   ORFNames=Dmoj_GI21488 {ECO:0000313|EMBL:KRG06973.1}, GI21488
GN   {ECO:0000313|FlyBase:FBgn0144218};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG06973.1, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:KRG06973.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH933811; KRG06973.1; -; Genomic_DNA.
DR   RefSeq; XP_015016637.1; XM_015161151.1.
DR   GeneID; 6585204; -.
DR   FlyBase; FBgn0144218; Dmoj\GI21488.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    160       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    204    226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    238    256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    262    284       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    394    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    799    822       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    843    860       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    872    896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    927    949       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    969    986       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1007   1028       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1305   1323       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1344   1366       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1372   1398       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1419   1450       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1537   1563       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1626   1644       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1656   1675       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1687   1706       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1750   1773       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1836   1859       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1880   1915       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      420    470       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2143 AA;  240646 MW;  30A71C86BE0D82F9 CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEI RYDDEDEDEG
     PQPDPTLEQG VPIPVRLQGS FPPELASTPL EDIDPYYSNV LTFVVVSKGK DIFRFSASKA
     MWLLDPFNPI RRVAIYILVH PLFSLFIITT ILVNCILMIM PTTPTVESTE VIFTGIYTFE
     SAVKVMARGF ILCPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA
     IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KKFPLDGSWG
     NLTDENWDYH NRNISNWYSE DDGISFPLCG NISGAGQCDD DYVCLQGFGP NPNYGYTSFD
     SFGWAFLSAF RLMTQDFWED LYQLVLRAAG PWHMLFFIVI IFLGSFYLVN LILAIVAMSY
     DELQKKAEEE EAAEEEAIRE AEEAAAAKAA KLEERANAQA QAAADAAAAE EAALHPEMAK
     SPTYSCISYE LFVGGEKGND DNNKEKMSIR SVEVESESVS VIQRQPAPTT AHQATKVRKV
     STTSLSLPGS PFNIRRGSRS SHKYTIRNGR GRFGIPGSDR KPLVLSTYQD AQQHLPYADD
     SNAVTPMSEE NGAIIVPVYY GNLGSRHSSY TSHQSRISYT SHGDLLGGMA VMGVSTMTKE
     SKLRNRNTRN QSVGASNGGT TCLDTNHKVE HRDYEIGLEC TDEAGKIKHH DNPFIEPVQT
     QTVVDMKDVM VLNDIIEQAA GRHSRASDRG VSVYYFPTED DDEDGPTFKD KALEVILKGI
     DVFCVWDCCW VWLKFQEWVS LIVFDPFVEL FITLCIVVNT MFMAMDHHDM NKEMERVLKS
     GNYFFTATFA IEATMKLMAM SPKYYFQEGW NIFDFIIVAL SLLELGLEGV QGLSVLRSFR
     LLRVFKLAKS WPTLNLLISI MGRTMGALGN LTFVLCIIIF IFAVMGMQLF GKNYHDHKDR
     FPDGDLPRWN FTDFMHSFMI VFRVLCGEWI ESMWDCMYVG DVSCIPFFLA TVVIGNLVVL
     NLFLALLLSN FGSSSLSAPT ADNDTNKIAE AFNRIGRFKS WVKRNIADCF KLIRNKLTNQ
     ISDQPSGERI NQISWIWSEE HGDNELELGH DEILADGLIK KGIKEQTQLE VAIGDGMEFT
     IHGDMKNNKP KKSKYLNNAT MIGNSINHQD NRLEHELNHR GLSLQDDDTA SINSYGSHKN
     RPFKDESHKG SAETMEGEEK RDASKEDLGL DEDLDEEGEC EEGPLDGDII IHANDEDILD
     EYPADCCPDS YYKKFPILAG DEDSPFWQGW GNLRLKTFQL IENKYFETAV ITMILMSSLA
     LALEDVHLPQ RPILQDILYY MDRIFTVIFF LEMLIKWLAL GFKVYFTNAW CWLDFVIVMV
     SLINFVASLV GAGGIQAFKT MRTLRALRPL RAMSRMQGMR VVVNALVQAI PSIFNVLLVC
     LIFWLIFAIM GVQLFAGKYF KCEDLNGTKL SHEIIPNRNA CESENYTWVN SAMNFDHVGN
     AYLCLFQVAT FKGWIQIMND AIDSREVDKQ PIRETNIYMY LYFVFFIIFG SFFTLNLFIG
     VIIDNFNEQK KKAGGSLEMF MTEDQKKYYN AMKKMGSKKP LKAIPRPRWR PQAIVFEIVT
     DKKFDIIIML FIGLNMFTMT LDRYDASDTY NAVLDYLNAI FVVIFSSECL LKIFALRYHY
     FIEPWNLFDV VVVILSILGL VLSDIIEKYF VSPTLLRVVR VAKVGRVLRL VKGAKGIRTL
     LFALAMSLPA LFNICLLLFL VMFIFAIFGM SFFMHVKEKS GINDVYNFKT FGQSMILLFQ
     MSTSAGWDGV LDAIINEEAC DPPDNDKGYP GNCGSATVGI TFLLSYLVIS FLIVINMYIA
     VILENYSQAT EDVQEGLTDD DYDMYYEIWQ QFDPEGTQYI RYDQLSEFLD VLEPPLQIHK
     PNKYKIISMD IPICRGDLMY CVDILDALTK DFFARKGNPI EETGEIGEIA ARPDTEGYEP
     VSSTLWRQRE EYCARLIQHA WRKHKARVES GGGGGGNDAD GEGNAEGGGD ADGSHDPADP
     GGADGHADAA DHNGPHDNDD PDAGGANGGH DPADADGGGI VNSPNDGNAN GSGSPGGQSA
     GSGGSAGRQT AVLVESDGFV TKNGHKVVIH SRSPSITSRT ADV
//
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