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Database: UniProt
Entry: A0A0Q9XMP0_DROMO
LinkDB: A0A0Q9XMP0_DROMO
Original site: A0A0Q9XMP0_DROMO 
ID   A0A0Q9XMP0_DROMO        Unreviewed;      2126 AA.
AC   A0A0Q9XMP0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dmoj\GI21488 {ECO:0000313|EMBL:KRG06970.1};
GN   ORFNames=Dmoj_GI21488 {ECO:0000313|EMBL:KRG06970.1}, GI21488
GN   {ECO:0000313|FlyBase:FBgn0144218};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG06970.1, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:KRG06970.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH933811; KRG06970.1; -; Genomic_DNA.
DR   RefSeq; XP_015016634.1; XM_015161148.1.
DR   GeneID; 6585204; -.
DR   FlyBase; FBgn0144218; Dmoj\GI21488.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    145    172       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    216    238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    274    296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    805       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    826    843       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    855    879       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    910    932       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    952    969       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    990   1011       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1288   1306       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1327   1349       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1355   1381       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1402   1433       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1520   1546       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1609   1627       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1639   1658       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1670   1689       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1733   1756       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1819   1842       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1863   1898       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      432    482       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2126 AA;  238825 MW;  42F8E81F181224D8 CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV PQYGRKKKQK
     EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST PLEDIDPYYS NVLTFVVVSK
     GKDIFRFSAS KAMWLLDPFN PIRRVAIYIL VHPLFSLFII TTILVNCILM IMPTTPTVES
     TEVIFTGIYT FESAVKVMAR GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR
     TFRVLRALKT VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK
     CIKKFPLDGS WGNLTDENWD YHNRNISNWY SEDDGISFPL CGNISGAGQC DDDYVCLQGF
     GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA AGPWHMLFFI VIIFLGSFYL
     VNLILAIVAM SYDELQKKAE EEEAAEEEAI REAEEAAAAK AAKLEERANA QAQAAADAAA
     AEEAALHPEM AKSPTYSCIS YELFVGGEKG NDDNNKEKMS IRSVEVESES VSVIQRQPAP
     TTAHQATKVR KVSTYTIRNG RGRFGIPGSD RKPLVLSTYQ DAQQHLPYAD DSNAVTPMSE
     ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM AVMGVSTMTK ESKLRNRNTR
     NQSVGASNGG TTCLDTNHKV EHRDYEIGLE CTDEAGKIKH HDNPFIEPVQ TQTVVDMKDV
     MVLNDIIEQA AGRHSRASDR GEDDDEDGPT FKDKALEVIL KGIDVFCVWD CCWVWLKFQE
     WVSLIVFDPF VELFITLCIV VNTMFMAMDH HDMNKEMERV LKSGNYFFTA TFAIEATMKL
     MAMSPKYYFQ EGWNIFDFII VALSLLELGL EGVQGLSVLR SFRLLRVFKL AKSWPTLNLL
     ISIMGRTVGA LGNLTFVLCI IIFIFAVMGM QLFGKNYTDH KDRFPDGDLP RWNFTDFMHS
     FMIVFRVLCG EWIESMWDCM YVGDVSCIPF FLATVVIGNL VVLNLFLALL LSNFGSSSLS
     APTADNDTNK IAEAFNRIGR FKSWVKRNIA DCFKLIRNKL TNQISDQPSG ERINQISWIW
     SEEHGDNELE LGHDEILADG LIKKGIKEQT QLEVAIGDGM EFTIHGDMKN NKPKKSKYLN
     NATMIGNSIN HQDNRLEHEL NHRGLSLQDD DTASINSYGS HKNRPFKDES HKGSAETMEG
     EEKRDASKED LGLDEDLDEE GECEEGPLDG DIIIHANDED ILDEYPADCC PDSYYKKFPI
     LAGDEDSPFW QGWGNLRLKT FQLIENKYFE TAVITMILMS SLALALEDVH LPQRPILQDI
     LYYMDRIFTV IFFLEMLIKW LALGFKVYFT NAWCWLDFVI VMVSLINFVA SLVGAGGIQA
     FKTMRTLRAL RPLRAMSRMQ GMRVVVNALV QAIPSIFNVL LVCLIFWLIF AIMGVQLFAG
     KYFKCEDLNG TKLSHEIIPN RNACESENYT WVNSAMNFDH VGNAYLCLFQ VATFKGWIQI
     MNDAIDSREV DKQPIRETNI YMYLYFVFFI IFGSFFTLNL FIGVIIDNFN EQKKKAGGSL
     EMFMTEDQKK YYNAMKKMGS KKPLKAIPRP RWRPQAIVFE IVTDKKFDII IMLFIGLNMF
     TMTLDRYDAS DTYNAVLDYL NAIFVVIFSS ECLLKIFALR YHYFIEPWNL FDVVVVILSI
     LGLVLSDIIE KYFVSPTLLR VVRVAKVGRV LRLVKGAKGI RTLLFALAMS LPALFNICLL
     LFLVMFIFAI FGMSFFMHVK EKSGINDVYN FKTFGQSMIL LFQMSTSAGW DGVLDAIINE
     EACDPPDNDK GYPGNCGSAT VGITFLLSYL VISFLIVINM YIAVILENYS QATEDVQEGL
     TDDDYDMYYE IWQQFDPEGT QYIRYDQLSE FLDVLEPPLQ IHKPNKYKII SMDIPICRGD
     LMYCVDILDA LTKDFFARKG NPIEETGEIG EIAARPDTEG YEPVSSTLWR QREEYCARLI
     QHAWRKHKAR VESGGGGGGN DADGEGNAEG GGDADGSHDP ADPGGADGHA DAADHNGPHD
     NDDPDAGGAN GGHDPADADG GGIVNSPNDG NANGSGSPGG QSAGSGGSAG RQTAVLVESD
     GFVTKNGHKV VIHSRSPSIT SRTADV
//
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