GenomeNet

Database: UniProt
Entry: A0A0Q9XMQ5_DROMO
LinkDB: A0A0Q9XMQ5_DROMO
Original site: A0A0Q9XMQ5_DROMO 
ID   A0A0Q9XMQ5_DROMO        Unreviewed;      2093 AA.
AC   A0A0Q9XMQ5;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dmoj\GI21488 {ECO:0000313|EMBL:KRG06986.1};
GN   ORFNames=Dmoj_GI21488 {ECO:0000313|EMBL:KRG06986.1}, GI21488
GN   {ECO:0000313|FlyBase:FBgn0144218};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG06986.1, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:KRG06986.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CH933811; KRG06986.1; -; Genomic_DNA.
DR   RefSeq; XP_015016650.1; XM_015161164.1.
DR   GeneID; 6585204; -.
DR   FlyBase; FBgn0144218; Dmoj\GI21488.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    145    172       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    216    238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    274    296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    787    810       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    831    848       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    860    884       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    915    937       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    995   1016       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1294   1316       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1322   1348       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1369   1400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1487   1513       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1576   1594       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1606   1625       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1637   1656       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1700   1723       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1786   1809       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1830   1865       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      432    482       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2093 AA;  235023 MW;  EB2F613E5BA9A98E CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV PQYGRKKKQK
     EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST PLEDIDPYYS NVLTFVVVSK
     GKDIFRFSAS KAMWLLDPFN PIRRVAIYIL VHPLFSLFII TTILVNCILM IMPTTPTVES
     TEVIFTGIYT FESAVKVMAR GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR
     TFRVLRALKT VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK
     CIKKFPLDGS WGNLTDENWD YHNRNISNWY SEDDGISFPL CGNISGAGQC DDDYVCLQGF
     GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA AGPWHMLFFI VIIFLGSFYL
     VNLILAIVAM SYDELQKKAE EEEAAEEEAI REAEEAAAAK AAKLEERANA QAQAAADAAA
     AEEAALHPEM AKSPTYSCIS YELFVGGEKG NDDNNKEKMS IRSVEVESES TSLSLPGSPF
     NIRRGSRSSH KYTIRNGRGR FGIPGSDRKP LVLSTYQDAQ QHLPYADDSN AVTPMSEENG
     AIIVPVYYGN LGSRHSSYTS HQSRISYTSH GDLLGGMAVM GVSTMTKESK LRNRNTRNQS
     VGASNGGTTC LDTNHKVEHR DYEIGLECTD EAGKIKHHDN PFIEPVQTQT VVDMKDVMVL
     NDIIEQAAGR HSRASDRGVS VYYFPTEDDD EDGPTFKDKA LEVILKGIDV FCVWDCCWVW
     LKFQEWVSLI VFDPFVELFI TLCIVVNTMF MAMDHHDMNK EMERVLKSGN YFFTATFAIE
     ATMKLMAMSP KYYFQEGWNI FDFIIVALSL LELGLEGVQG LSVLRSFRLL RVFKLAKSWP
     TLNLLISIMG RTMGALGNLT FVLCIIIFIF AVMGMQLFGK NYHDHKDRFP DGDLPRWNFT
     DFMHSFMIVF RVLCGEWIES MWDCMYVGDV SCIPFFLATV VIGNLVVLNL FLALLLSNFG
     SSSLSAPTAD NDTNKIAEAF NRIGRFKSWV KRNIADCFKL IRNKLTNQIS DQPSEHGDNE
     LELGHDEILA DGLIKKGIKE QTQLEVAIGD GMEFTIHGDM KNNKPKKSKY LNNATDDDTA
     SINSYGSHKN RPFKDESHKG SAETMEGEEK RDASKEDLGL DEDLDEEGEC EEGPLDGDII
     IHANDEDILD EYPADCCPDS YYKKFPILAG DEDSPFWQGW GNLRLKTFQL IENKYFETAV
     ITMILMSSLA LALEDVHLPQ RPILQDILYY MDRIFTVIFF LEMLIKWLAL GFKVYFTNAW
     CWLDFVIVMV SLINFVASLV GAGGIQAFKT MRTLRALRPL RAMSRMQGMR VVVNALVQAI
     PSIFNVLLVC LIFWLIFAIM GVQLFAGKYF KCEDLNGTKL SHEIIPNRNA CESENYTWVN
     SAMNFDHVGN AYLCLFQVAT FKGWIQIMND AIDSREVDKQ PIRETNIYMY LYFVFFIIFG
     SFFTLNLFIG VIIDNFNEQK KKAGGSLEMF MTEDQKKYYN AMKKMGSKKP LKAIPRPRWR
     PQAIVFEIVT DKKFDIIIML FIGLNMFTMT LDRYDASDTY NAVLDYLNAI FVVIFSSECL
     LKIFALRYHY FIEPWNLFDV VVVILSILGL VLSDIIEKYF VSPTLLRVVR VAKVGRVLRL
     VKGAKGIRTL LFALAMSLPA LFNICLLLFL VMFIFAIFGM SFFMHVKEKS GINDVYNFKT
     FGQSMILLFQ MSTSAGWDGV LDAIINEEAC DPPDNDKGYP GNCGSATVGI TFLLSYLVIS
     FLIVINMYIA VILENYSQAT EDVQEGLTDD DYDMYYEIWQ QFDPEGTQYI RYDQLSEFLD
     VLEPPLQIHK PNKYKIISMD IPICRGDLMY CVDILDALTK DFFARKGNPI EETGEIGEIA
     ARPDTEGYEP VSSTLWRQRE EYCARLIQHA WRKHKARVES GGGGGGNDAD GEGNAEGGGD
     ADGSHDPADP GGADGHADAA DHNGPHDNDD PDAGGANGGH DPADADGGGI VNSPNDGNAN
     GSGSPGGQSA GSGGSAGRQT AVLVESDGFV TKNGHKVVIH SRSPSITSRT ADV
//
DBGET integrated database retrieval system