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Database: UniProt
Entry: A0A0Q9XNX1_DROMO
LinkDB: A0A0Q9XNX1_DROMO
Original site: A0A0Q9XNX1_DROMO 
ID   A0A0Q9XNX1_DROMO        Unreviewed;      2098 AA.
AC   A0A0Q9XNX1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dmoj\GI21488 {ECO:0000313|EMBL:KRG06996.1};
GN   ORFNames=Dmoj_GI21488 {ECO:0000313|EMBL:KRG06996.1}, GI21488
GN   {ECO:0000313|FlyBase:FBgn0144218};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG06996.1, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:KRG06996.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH933811; KRG06996.1; -; Genomic_DNA.
DR   RefSeq; XP_015016660.1; XM_015161174.1.
DR   GeneID; 6585204; -.
DR   FlyBase; FBgn0144218; Dmoj\GI21488.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    145    172       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    216    238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    274    296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    779    802       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    823    840       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    852    876       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    907    929       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    987   1008       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1299   1321       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1327   1353       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1374   1405       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1492   1518       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1581   1599       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1611   1630       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1642   1661       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1705   1728       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1791   1814       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1835   1870       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      432    482       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2098 AA;  235597 MW;  A01C50E0958C61A5 CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV PQYGRKKKQK
     EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST PLEDIDPYYS NVLTFVVVSK
     GKDIFRFSAS KAMWLLDPFN PIRRVAIYIL VHPLFSLFII TTILVNCILM IMPTTPTVES
     TEVIFTGIYT FESAVKVMAR GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR
     TFRVLRALKT VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK
     CIKKFPLDGS WGNLTDENWD YHNRNISNWY SEDDGISFPL CGNISGAGQC DDDYVCLQGF
     GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA AGPWHMLFFI VIIFLGSFYL
     VNLILAIVAM SYDELQKKAE EEEAAEEEAI REAEEAAAAK AAKLEERANA QAQAAADAAA
     AEEAALHPEM AKSPTYSCIS YELFVGGEKG NDDNNKEKMS IRSVEVESES TSLSLPGSPF
     NIRRGSRSSH KYTIRNGRGR FGIPGSDRKP LVLSTYQDAQ QHLPYADDSN AVTPMSEENG
     AIIVPVYYGN LGSRHSSYTS HQSRISYTSH GDLLGGMAVM GVSTMTKESK LRNRNTRNQS
     VGASNGGTTC LDTNHKVEHR DYEIGLECTD EAGKIKHHDN PFIEPVQTQT VVDMKDVMVL
     NDIIEQAAGR HSRASDRGED DDEDGPTFKD KALEVILKGI DVFCVWDCCW VWLKFQEWVS
     LIVFDPFVEL FITLCIVVNT MFMAMDHHDM NKEMERVLKS GNYFFTATFA IEATMKLMAM
     SPKYYFQEGW NIFDFIIVAL SLLELGLEGV QGLSVLRSFR LLRVFKLAKS WPTLNLLISI
     MGRTVGALGN LTFVLCIIIF IFAVMGMQLF GKNYTDHKDR FPDGDLPRWN FTDFMHSFMI
     VFRVLCGEWI ESMWDCMYVG DVSCIPFFLA TVVIGNLVVL NLFLALLLSN FGSSSLSAPT
     ADNDTNKIAE AFNRIGRFKS WVKRNIADCF KLIRNKLTNQ ISDQPSGERI NQISWIWSEE
     HGDNELELGH DEILADGLIK KGIKEQTQLE VAIGDGMEFT IHGDMKNNKP KKSKYLNNAT
     DDDTASINSY GSHKNRPFKD ESHKGSAETM EGEEKRDASK EDLGLDEDLD EEGECEEGPL
     DGDIIIHAND EDILDEYPAD CCPDSYYKKF PILAGDEDSP FWQGWGNLRL KTFQLIENKY
     FETAVITMIL MSSLALALED VHLPQRPILQ DILYYMDRIF TVIFFLEMLI KWLALGFKVY
     FTNAWCWLDF VIVMVSLINF VASLVGAGGI QAFKTMRTLR ALRPLRAMSR MQGMRVVVNA
     LVQAIPSIFN VLLVCLIFWL IFAIMGVQLF AGKYFKCEDL NGTKLSHEII PNRNACESEN
     YTWVNSAMNF DHVGNAYLCL FQVATFKGWI QIMNDAIDSR EVDKQPIRET NIYMYLYFVF
     FIIFGSFFTL NLFIGVIIDN FNEQKKKAGG SLEMFMTEDQ KKYYNAMKKM GSKKPLKAIP
     RPRWRPQAIV FEIVTDKKFD IIIMLFIGLN MFTMTLDRYD ASDTYNAVLD YLNAIFVVIF
     SSECLLKIFA LRYHYFIEPW NLFDVVVVIL SILGLVLSDI IEKYFVSPTL LRVVRVAKVG
     RVLRLVKGAK GIRTLLFALA MSLPALFNIC LLLFLVMFIF AIFGMSFFMH VKEKSGINDV
     YNFKTFGQSM ILLFQMSTSA GWDGVLDAII NEEACDPPDN DKGYPGNCGS ATVGITFLLS
     YLVISFLIVI NMYIAVILEN YSQATEDVQE GLTDDDYDMY YEIWQQFDPE GTQYIRYDQL
     SEFLDVLEPP LQIHKPNKYK IISMDIPICR GDLMYCVDIL DALTKDFFAR KGNPIEETGE
     IGEIAARPDT EGYEPVSSTL WRQREEYCAR LIQHAWRKHK ARVESGGGGG GNDADGEGNA
     EGGGDADGSH DPADPGGADG HADAADHNGP HDNDDPDAGG ANGGHDPADA DGGGIVNSPN
     DGNANGSGSP GGQSAGSGGS AGRQTAVLVE SDGFVTKNGH KVVIHSRSPS ITSRTADV
//
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