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Database: UniProt
Entry: A0A0Q9XPM9_DROMO
LinkDB: A0A0Q9XPM9_DROMO
Original site: A0A0Q9XPM9_DROMO 
ID   A0A0Q9XPM9_DROMO        Unreviewed;      2154 AA.
AC   A0A0Q9XPM9;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   30-AUG-2017, entry version 14.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dmoj\GI21488 {ECO:0000313|EMBL:KRG06958.1};
GN   ORFNames=Dmoj_GI21488 {ECO:0000313|EMBL:KRG06958.1}, GI21488
GN   {ECO:0000313|FlyBase:FBgn0144218};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:KRG06958.1, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:KRG06958.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH933811; KRG06958.1; -; Genomic_DNA.
DR   RefSeq; XP_015016622.1; XM_015161136.1.
DR   GeneID; 6585204; -.
DR   FlyBase; FBgn0144218; Dmoj\GI21488.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:EnsemblMetazoa.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    144    171       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    215    237       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    273    295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    405    427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    810    833       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    854    871       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    883    907       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    938    960       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    980    997       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1018   1039       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1316   1334       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1355   1377       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1383   1409       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1430   1461       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1548   1574       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1637   1655       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1667   1686       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1698   1717       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1761   1784       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1847   1870       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1891   1926       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      431    481       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2154 AA;  241950 MW;  4A5269CA6510154D CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEP QYGRKKKQKE
     IRYDDEDEDE GPQPDPTLEQ GVPIPVRLQG SFPPELASTP LEDIDPYYSN VLTFVVVSKG
     KDIFRFSASK AMWLLDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTVEST
     EVIFTGIYTF ESAVKVMARG FILCPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT
     FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC
     IKKFPLDGSW GNLTDENWDY HNRNISNWYS EDDGISFPLC GNISGAGQCD DDYVCLQGFG
     PNPNYGYTSF DSFGWAFLSA FRLMTQDFWE DLYQLVLRAA GPWHMLFFIV IIFLGSFYLV
     NLILAIVAMS YDELQKKAEE EEAAEEEAIR EAEEAAAAKA AKLEERANAQ AQAAADAAAA
     EEAALHPEMA KSPTYSCISY ELFVGGEKGN DDNNKEKMSI RSVEVESESV SVIQRQPAPT
     TAHQATKVRK VSTTSLSLPG SPFNIRRGSR SSHKYTIRNG RGRFGIPGSD RKPLVLSTYQ
     DAQQHLPYAD DSNAVTPMSE ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM
     AVMGVSTMTK ESKLRNRNTR NQSVGASNGG TTCLDTNHKV EHRDYEIGLE CTDEAGKIKH
     HDNPFIEPVQ TQTVVDMKDV MVLNDIIEQA AGRHSRASDR GVSVYYFPTE DDDEDGPTFK
     DKALEVILKG IDVFCVWDCC WVWLKFQEWV SLIVFDPFVE LFITLCIVVN TMFMAMDHHD
     MNKEMERVLK SGNYFFTATF AIEATMKLMA MSPKYYFQEG WNIFDFIIVA LSLLELGLEG
     VQGLSVLRSF RLLRVFKLAK SWPTLNLLIS IMGRTVGALG NLTFVLCIII FIFAVMGMQL
     FGKNYTDHKD RFPDGDLPRW NFTDFMHSFM IVFRVLCGEW IESMWDCMYV GDVSCIPFFL
     ATVVIGNLVV LNLFLALLLS NFGSSSLSAP TADNDTNKIA EAFNRIGRFK SWVKRNIADC
     FKLIRNKLTN QISDQPSGER INQISWIWSE EHGDNELELG HDEILADGLI KKGIKEQTQL
     EVAIGDGMEF TIHGDMKNNK PKKSKYLNNA TMIGNSINHQ DNRLEHELNH RGLSLQDDDT
     ASINSYGSHK NRPFKDESHK GSAETMEGEE KRDASKEDLG LDEDLDEEGE CEEGPLDGDI
     IIHANDEDIL DEYPADCCPD SYYKKFPILA GDEDSPFWQG WGNLRLKTFQ LIENKYFETA
     VITMILMSSL ALALEDVHLP QRPILQDILY YMDRIFTVIF FLEMLIKWLA LGFKVYFTNA
     WCWLDFVIVM VSLINFVASL VGAGGIQAFK TMRTLRALRP LRAMSRMQGM RVVVNALVQA
     IPSIFNVLLV CLIFWLIFAI MGVQLFAGKY FKCEDLNGTK LSHEIIPNRN ACESENYTWV
     NSAMNFDHVG NAYLCLFQVA TFKGWIQIMN DAIDSREVDK QPIRETNIYM YLYFVFFIIF
     GSFFTLNLFI GVIIDNFNEQ KKKAGGSLEM FMTEDQKKYY NAMKKMGSKK PLKAIPRPRW
     RPQAIVFEIV TDKKFDIIIM LFIGLNMFTM TLDRYDASDT YNAVLDYLNA IFVVIFSSEC
     LLKIFALRYH YFIEPWNLFD VVVVILSILG LVLSDIIEKY FVSPTLLRVV RVAKVGRVLR
     LVKGAKGIRT LLFALAMSLP ALFNICLLLF LVMFIFAIFG MSFFMHVKEK SGINDVYNFK
     TFGQSMILLF QMSTSAGWDG VLDAIINEEA CDPPDNDKGY PGNCGSATVG ITFLLSYLVI
     SFLIVINMYI AVILENYSQA TEDVQEGLTD DDYDMYYEIW QQFDPEGTQY IRYDQLSEFL
     DVLEPPLQIH KPNKYKIISM DIPICRGDLM YCVDILDALT KDFFARKGNP IEETGEIGEI
     AARPDTEGYE PVSSTLWRQR EEYCARLIQH AWRKHKARVE SGGGGGGNDA DGEGNAEGGG
     DADGSHDPAD PGGADGHADA ADHNGPHDND DPDAGGANGG HDPADADGGG IVNSPNDGNA
     NGSGSPGGQS AGSGGSAGRQ TAVLVESDGF VTKNGHKVVI HSRSPSITSR TADV
//
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