ID A0A0R0AMU0_9GAMM Unreviewed; 790 AA.
AC A0A0R0AMU0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KRG42830.1};
GN ORFNames=ARC20_10445 {ECO:0000313|EMBL:KRG42830.1};
OS Stenotrophomonas panacihumi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Stenotrophomonas.
OX NCBI_TaxID=676599 {ECO:0000313|EMBL:KRG42830.1, ECO:0000313|Proteomes:UP000051802};
RN [1] {ECO:0000313|EMBL:KRG42830.1, ECO:0000313|Proteomes:UP000051802}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 16536 {ECO:0000313|EMBL:KRG42830.1,
RC ECO:0000313|Proteomes:UP000051802};
RA Patil P.P., Midha S., Patil P.B.;
RT "Genome sequencing and analysis of members of genus Stenotrophomonas.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRG42830.1}.
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DR EMBL; LLXU01000079; KRG42830.1; -; Genomic_DNA.
DR RefSeq; WP_057646646.1; NZ_PZOY01000004.1.
DR AlphaFoldDB; A0A0R0AMU0; -.
DR STRING; 676599.ARC20_10445; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000051802; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000051802}.
FT DOMAIN 10..192
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 195..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 790 AA; 85472 MW; 261417BEABA22222 CRC64;
MSNPLLVRRA AVLGAGVMGA QIAAHLTNAG VDTVLFDLAA KEGPADGIVL KAIANLGKLS
PAPLASKGLA EAITPANYDT GLEQLRGCDL IIEAIAERMD WKQDLYAKIA PFVSDTAVLA
SNTSGLGINK LAEVLPEQLR HRFCGVHFFN PPRYMHLAEL IPAKGTDKSV LEGLETFLTT
TLGKGVVYAK DTPNFIGNRI GVFSILSTIH HTEQFGLGFD EVDGLTGPLV GRPKSATYRT
SDVVGLDTMA HVIKTMADTL PDDPWHAFFK SPKWLEALIA KGALGQKTGA GIFRKVGKDI
VVLDVAKQDY RPADRAAAPE VVEILKIKNP AEKFAKLRES QHPQAQFLWA TFRDLFHYSA
YHLADIADTA RDVDLAIRWG YGWSLGPFET WQAAGWKQVA QWIADDIAAG KSMSNAPLPN
WVFDGRDGVH AAEGSYSPAR DAKLPRSSLP VYRRQRFPDP LLGEKFSPGE TVFENDGLRM
WHDGDDIAVV GFKTKMNTVS DQVLDGLQEA VGRAEKDFKG LVIWQQKEPF SAGADLAGAL
GALQAGKIAE FEAMVANFQR TSQRIKYSLV PVVAAVRGLA LGGGCEFQMH SAKTVAALES
YIGLVEAGVG LLPAGGGLKE LAVRASEAAG PGGDVFAELK KTFETVAMAK VSNSAVNAKE
LGLLRQTDKV VFNTFESLYI AKAEALALAE GGYRPPMPAN RIQVAGDVGI ATFKMLLVNM
LEGRFISEYD YEIASRIATV VCGGEVDRGA LVDEEWLLKL ERQHFVELAQ QEKTQARIAH
MLKTGKPLRN
//
