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Database: UniProt
Entry: A0A0R0LU12_9PROT
LinkDB: A0A0R0LU12_9PROT
Original site: A0A0R0LU12_9PROT 
ID   A0A0R0LU12_9PROT        Unreviewed;       440 AA.
AC   A0A0R0LU12;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KRH79396.1};
GN   ORFNames=FERRO_04610 {ECO:0000313|EMBL:KRH79396.1};
OS   Ferrovum sp. JA12.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Ferrovales; Ferrovaceae;
OC   Ferrovum.
OX   NCBI_TaxID=1356299 {ECO:0000313|EMBL:KRH79396.1, ECO:0000313|Proteomes:UP000050960};
RN   [1] {ECO:0000313|EMBL:KRH79396.1, ECO:0000313|Proteomes:UP000050960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA12 {ECO:0000313|EMBL:KRH79396.1,
RC   ECO:0000313|Proteomes:UP000050960};
RA   Poehlein A., Ullrich S.R., Tischler J.S., Schloemann M., Muehling M.,
RA   Daniel R.;
RT   "Genome sequence of the acidophilic iron oxidising Ferrovum strain
RT   JA12.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRH79396.1}.
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DR   EMBL; LJWX01000001; KRH79396.1; -; Genomic_DNA.
DR   EnsemblBacteria; KRH79396; KRH79396; FERRO_04610.
DR   PATRIC; fig|1356299.4.peg.464; -.
DR   Proteomes; UP000050960; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050960};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050960}.
FT   DOMAIN      137    267       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      348    417       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     145    152       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   440 AA;  50359 MW;  B04A7E09B47D421F CRC64;
     MSFWNHIKNQ FRQEIPEQQF ATWIEPLLVN EDNGQLTIIA NNRFVLQWIK DRFFVKIEEL
     AKKEGFTEVI LVTQRINAKP TINSVTHNQN IPLTEPQQTP YPSKLNPQFT LDNFIAGKAN
     QLARAAAIQV AENPGQAYNP LFIYGGVGLG KTHLIQAIGN EVVRRNPKAR VKYVHAEKYV
     SDVVRTYQHK SFDSFKKEYH SLDVLMVDDI QFFGGKTRTQ EEFFFAFNAL VESHKQVIIA
     CDSFPREIMG MEERLISRFG WGLTVAVEAP ELEMRVAILI NKAKQQHIDL NEDVAFFIAK
     HIRSHVRELE GALKRVQAYS GFKNEPITLL SAKESLKDLL ALKHRQISVE NIQKTVADYY
     KIKVADMFSK KRTRSLARPR QMAMALAKDI TSLSLPDIGD AFGGRDHTTV LHACRKMQEL
     CISDQTILRD YQALQQILSS
//
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