ID   A0A0R0MFS5_9BURK        Unreviewed;       939 AA.
AC   A0A0R0MFS5;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Diguanylate cyclase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AO057_02240 {ECO:0000313|EMBL:KRH99365.1};
OS   Curvibacter sp. PAE-UM.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Curvibacter.
OX   NCBI_TaxID=1714344 {ECO:0000313|EMBL:KRH99365.1, ECO:0000313|Proteomes:UP000051912};
RN   [1] {ECO:0000313|EMBL:KRH99365.1, ECO:0000313|Proteomes:UP000051912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PAE-UM {ECO:0000313|EMBL:KRH99365.1,
RC   ECO:0000313|Proteomes:UP000051912};
RA   Ma D.;
RT   "The whole genome sequence of a typical ultramicrobacteria PAE-UM from
RT   river sediment.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRH99365.1}.
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DR   EMBL; LKCX01000028; KRH99365.1; -; Genomic_DNA.
DR   RefSeq; WP_057674092.1; NZ_KQ483358.1.
DR   AlphaFoldDB; A0A0R0MFS5; -.
DR   STRING; 1714344.AO057_02240; -.
DR   Proteomes; UP000051912; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051912};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        22..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        267..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          291..343
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          539..672
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          681..934
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   939 AA;  103744 MW;  7646BDB744B1874B CRC64;
     MFPLLKLPIQ GLFLRSQVAR RVFLLFLLSA LIPALLLAVL AYWHMRTMDE QHVNRQLALE
     AGNYTSGLYE RLLGAHFMLS VQAAGLRQGL TVADTSPDRA HRVFKRINVH EKALSDSPQD
     AALGERLQQP QALAHLARSD SVLLTLPDAA GARIELATAI DPAQAARGVL LAELEPEHVW
     GDADDLAHQT QACVLDAAAQ VLYCSDMQLM AVAADIAAQG LDQTTGTSGV WQFNTRRLFL
     RARFAVDDWT VITLRPQGAS DAGWGRLAYY FLGIILLTLL LVALLSGVQL RRILVPLERL
     IDGTRRIARE EFAQPVMVRR DDEFGQLAQA LNKMAARLGR QMGTLRALAE IDHEILSRVD
     MEQIISRVQE RLHELWPKAV TSMVVFDQQA ADFGIVHLYS GVNDVTSKMP SRLEPWLLEQ
     LARDYDGMWF DVGGGELPDF LSMVADAGAR RILVLPIFWN EKVSGLLAIG LLEPREFSNE
     LVQQARDLVN RIGVALAAHA RDEQLKFRAY HDALTGLPNR PLLVERLNQE MAHTRRNGKQ
     LAVLFIDLDR FKKINDSLGH EGGDRLLCQV AERLTSCTRE GDTVARMGGD EFVVLLPDLG
     NAQLAARLAS EMLGLLAEPF IIEGSSNYVG ASIGVAIFPD DGSIAPELLK KADMAMYRAK
     ATGRGRIIFF EESMNIVQQE QSVLERELRQ AITRGQLSLR YQPRIRLSDG KLSGAEALLR
     WLHPELGWVS PEKFIPLAEE VGLIDEIGGW VLRHVCEQLG HWQTAGYRIT LSVNVSGRQL
     KSGRLGQQVQ QSLNESGVVP AALELEVTEG TLIDNIEEVG EQLGQIKQTG VGIALDDFGT
     GYSSLSYLQR LPIDILKIDR SFIRELGRSD GAGSIVHSII ALAHALGKTV VAEGVESEEQ
     AELLRIWQCE QAQGNHYSLP ITAAELEALM TPSRPAEIA
//