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Database: UniProt
Entry: A0A0R1HGU7_9LACO
LinkDB: A0A0R1HGU7_9LACO
Original site: A0A0R1HGU7_9LACO 
ID   A0A0R1HGU7_9LACO        Unreviewed;       657 AA.
AC   A0A0R1HGU7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   ORFNames=FC66_GL001509 {ECO:0000313|EMBL:KRK45392.1};
OS   Dellaglioa algida DSM 15638.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Dellaglioa.
OX   NCBI_TaxID=1423719 {ECO:0000313|EMBL:KRK45392.1, ECO:0000313|Proteomes:UP000051450};
RN   [1] {ECO:0000313|EMBL:KRK45392.1, ECO:0000313|Proteomes:UP000051450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15638 {ECO:0000313|EMBL:KRK45392.1,
RC   ECO:0000313|Proteomes:UP000051450};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRK45392.1}.
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DR   EMBL; AZDI01000009; KRK45392.1; -; Genomic_DNA.
DR   RefSeq; WP_057974559.1; NZ_AZDI01000009.1.
DR   AlphaFoldDB; A0A0R1HGU7; -.
DR   STRING; 1423719.FC66_GL001509; -.
DR   PATRIC; fig|1423719.4.peg.1535; -.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000051450; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000051450}.
FT   DOMAIN          208..326
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          462..604
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   657 AA;  73592 MW;  C9FC5A659B9654AA CRC64;
     MTKIIELPTI LADQIAAGEV VERPASVVKE LVENAIDAHA TQIDVVVEEA GLKSIKIIDN
     GDGIESSQVE NAFKRHATSK ITTREDLFKI STLGFRGEAL PSIASVAKVT MNTAVAGQSG
     AFIAVNGGKI VDEKSSASRK GTEITVSDLF FNTPARLKYV KSLQTEMSVI SDMMNRLAMS
     HTTISFSLTH GDKEVLRTTG NGQLQQTISA IYGVKSARQM LEFSGHDLDF KISGYTSLPE
     LTRAGRQFIS ILINGRYVKN TSLNKAIIKG YGSKLMVGRY PVTVLNIQLD PLLVDVNVHP
     TKQEVRLSKE SELTELIKKV IYERIAKENL IPEALENLSS KKREKIDTDQ LQFDLNEASS
     KYQSKPNFVL GKKKSVASTP VDVSSSEKLN ELSEAIEPIS IQVAEQLESK RVSDFENRYA
     NEDNLEPFSI DQRVNLVDEK EISDEEELTT KKSEQRFPDL KYIGQMHGTY LFTESEDGLY
     ILDQHAAQER INYEFYRKQI GEVSSDSQNL LVPIVLEYTA SEAMIITEHT EILSEVGLVL
     EPFGQNSFII RQHPTWFKEG QEESTIREMI DYLLADGKIS VAEFREKSAI MMSCKRAIKA
     NHHLDDRQSK ALIADLKSVE NPFNCPHGRP VLVHFSNQDM EHFFKRIQES HQTGHEG
//
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