ID A0A0R1HXD6_9LACO Unreviewed; 310 AA.
AC A0A0R1HXD6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN ORFNames=FC96_GL000156 {ECO:0000313|EMBL:KRK49235.1};
OS Secundilactobacillus kimchicus JCM 15530.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Secundilactobacillus.
OX NCBI_TaxID=1302272 {ECO:0000313|EMBL:KRK49235.1, ECO:0000313|Proteomes:UP000050911};
RN [1] {ECO:0000313|EMBL:KRK49235.1, ECO:0000313|Proteomes:UP000050911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 15530 {ECO:0000313|EMBL:KRK49235.1,
RC ECO:0000313|Proteomes:UP000050911};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000256|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|HAMAP-Rule:MF_01811}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|HAMAP-Rule:MF_01811}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01811}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRK49235.1}.
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DR EMBL; AZCX01000001; KRK49235.1; -; Genomic_DNA.
DR RefSeq; WP_056941648.1; NZ_AZCX01000001.1.
DR AlphaFoldDB; A0A0R1HXD6; -.
DR STRING; 1302272.FC96_GL000156; -.
DR PATRIC; fig|1302272.5.peg.154; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000050911; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
KW Chaperone {ECO:0000256|HAMAP-Rule:MF_01811};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01811};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01811}; Reference proteome {ECO:0000313|Proteomes:UP000050911};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_01811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01811}.
FT TRANSMEM 50..74
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 131..156
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 176..193
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 205..224
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT DOMAIN 59..247
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 265..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 310 AA; 34390 MW; 2BBC1E949A9C7525 CRC64;
MKNKKPIQLA LLLGVLTLFL SGCVQRTKSG KPFGLVYDYL AVPGQHVMEW AANLLGHSYG
WAIIAVTIIV RLVLLPVMMS QMRKSTVQME KMNAIRPHMT KLQERQKNAK TPEEQAAASQ
QMMQLYRDNG ISMTGGIGCL PLLIQMPIFA ALYAAIQYSP ELSSSVFFGI NLGKPSIVLA
ILSFLSYFLQ GYLSMIGMPA EQRKTMRMTM VISPAFILFI TLSAPAGLGL YFFIGGLFAC
LQTLLVNMAR PRIRRQIEAE MKKNPPKIVD VDIPEPAVTP TQSNGSSATT QPAPRNNRQR
NAGKQRHHHD
//
