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Database: UniProt
Entry: A0A0R1JRA8_9LACO
LinkDB: A0A0R1JRA8_9LACO
Original site: A0A0R1JRA8_9LACO 
ID   A0A0R1JRA8_9LACO        Unreviewed;       331 AA.
AC   A0A0R1JRA8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=D-lactate dehydrogenase {ECO:0000313|EMBL:KRK73823.1};
GN   ORFNames=FD02_GL001653 {ECO:0000313|EMBL:KRK73823.1};
OS   Lacticaseibacillus nasuensis JCM 17158.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1291734 {ECO:0000313|EMBL:KRK73823.1, ECO:0000313|Proteomes:UP000051804};
RN   [1] {ECO:0000313|EMBL:KRK73823.1, ECO:0000313|Proteomes:UP000051804}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 17158 {ECO:0000313|EMBL:KRK73823.1,
RC   ECO:0000313|Proteomes:UP000051804};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC       ECO:0000256|RuleBase:RU003719}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRK73823.1}.
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DR   EMBL; AZDJ01000003; KRK73823.1; -; Genomic_DNA.
DR   RefSeq; WP_056950000.1; NZ_AZDJ01000003.1.
DR   AlphaFoldDB; A0A0R1JRA8; -.
DR   STRING; 1291734.FD02_GL001653; -.
DR   PATRIC; fig|1291734.4.peg.1701; -.
DR   OrthoDB; 9805416at2; -.
DR   Proteomes; UP000051804; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd12186; LDH; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43026; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR   PANTHER; PTHR43026:SF1; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051804}.
FT   DOMAIN          13..328
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          111..297
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   331 AA;  36190 MW;  3C30E5E80B42FAC4 CRC64;
     MKIIAYGARI DEIPYMQQWA KETGNTLTIH EELLDASTVD WAKGYEGVNA LQTTPYSAEV
     FAKLHEFGIH YLAVRNVGTD NIDLAAAAAN DVKISNVPAY SPAAIAEFAV TLTLQVLRRV
     GEVAARLQAD DYDGATKFIG RELGQQTVGV IGAGRIGRTA IRIFEGFGAK VQAYDPYPVT
     DQDHLIDYVG LDELLRTSDV IDLHIPGIPA NTHIIDSAAI ASMKPNAVLI NTARGNLVDT
     EAMVAALREH RLAGAGIDTY EHETADLLTL SKEGRFHDPL WDELLAMPNV VLTPHIAYYT
     ETAVHNMVYF SLQHLVDFLT TGTTSTEVKR T
//
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