ID A0A0R1SDV0_9LACO Unreviewed; 685 AA.
AC A0A0R1SDV0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:KRL64610.1};
GN ORFNames=FC85_GL001124 {ECO:0000313|EMBL:KRL64610.1};
OS Lentilactobacillus diolivorans DSM 14421.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lentilactobacillus.
OX NCBI_TaxID=1423739 {ECO:0000313|EMBL:KRL64610.1, ECO:0000313|Proteomes:UP000052013};
RN [1] {ECO:0000313|EMBL:KRL64610.1, ECO:0000313|Proteomes:UP000052013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14421 {ECO:0000313|EMBL:KRL64610.1,
RC ECO:0000313|Proteomes:UP000052013};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRL64610.1}.
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DR EMBL; AZEY01000090; KRL64610.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R1SDV0; -.
DR STRING; 1423739.FC85_GL001124; -.
DR PATRIC; fig|1423739.3.peg.1175; -.
DR Proteomes; UP000052013; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052013};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..304
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 346..670
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 685 AA; 73655 MW; 7189B0A50AAB44A0 CRC64;
MKIFKKRNRN KKVKKSKAAS LPFRINIIFI VVGILFIALL TQLAYLQVMY GSKFKAEVNR
SDTSVVSGNV QRGMIYDSEG KVLVGNSAHQ AIVYTKGVNE LTTDIYKTAT KLAQYVKVPT
SSLTKRQLAD YYLSEPDRLT NIEGKLSGLS GYSADAKYNK ALAYVEKMPS VTFSKSMKNA
ATIFAKMSGA YQLSTVNIKD DHVSQREVAE VGEHLSEMSG VNVGTSWSRN YPSGTAIQGI
TGTVSNEKTG LPSDRVNELL AQGYSRNDSV GQSYLERQYE PVLRGTKSQT QVVLNSDNEI
KKEIKKYGGQ KGDNLQLTIN GRFQKKLQSL VHSAEQGAGG NSTGTYAVVM DPDNGAIIGM
AGVNRNPSTS KITDNILGTI NSSIVMGSVV KGAMVSGALM DGVITPTNST LTDQPITTGG
VKKSSWFNHG GSANIAVDAS TALEVSSNSY MMQLAMKEGH FHYVEGGALT MKPTVFNTMR
GYFNQFGLGV DTGIDIPGES TGLKGASGSS HIGSALDLAF GNYDAYTTMQ VAQYMSTIAN
GGYRIQPHVV QAIRGTSKDG ELGKIKATVM PHVLNQINMT SSQKAVVKRG LYDVVHGTNT
YKTGGMLDSI KPEISAKTGT AQTFYKGNET VTLSLASYAP STHPQVVVAL AMPNLGVNAE
SNNMALAKQI YAAYWKYVQS TSTVK
//
