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Database: UniProt
Entry: A0A0R1WN70_9LACO
LinkDB: A0A0R1WN70_9LACO
Original site: A0A0R1WN70_9LACO 
ID   A0A0R1WN70_9LACO        Unreviewed;       342 AA.
AC   A0A0R1WN70;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 12.
DE   RecName: Full=Lipoate--protein ligase {ECO:0000256|SAAS:SAAS00603724};
DE            EC=6.3.1.20 {ECO:0000256|SAAS:SAAS00603724};
GN   ORFNames=FC40_GL000179 {ECO:0000313|EMBL:KRM19368.1};
OS   Lactobacillus hayakitensis DSM 18933 = JCM 14209.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1423755 {ECO:0000313|EMBL:KRM19368.1, ECO:0000313|Proteomes:UP000051054};
RN   [1] {ECO:0000313|EMBL:KRM19368.1, ECO:0000313|Proteomes:UP000051054}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18933 {ECO:0000313|EMBL:KRM19368.1,
RC   ECO:0000313|Proteomes:UP000051054};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O.,
RA   Ritari J., Douillard F.P., Paul Ross R., Yang R., Briner A.E.,
RA   Felis G.E., de Vos W.M., Barrangou R., Klaenhammer T.R.,
RA   Caufield P.W., Cui Y., Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through
RT   comparative genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-lipoate + a [lipoyl-carrier
CC       protein]-L-lysine = a [lipoyl-carrier protein]-N(6)-(lipoyl)lysine
CC       + AMP + diphosphate. {ECO:0000256|SAAS:SAAS00603726}.
CC   -!- PATHWAY: Protein modification; protein lipoylation via exogenous
CC       pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.
CC       {ECO:0000256|SAAS:SAAS00701662}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRM19368.1}.
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DR   EMBL; AZGD01000052; KRM19368.1; -; Genomic_DNA.
DR   EnsemblBacteria; KRM19368; KRM19368; FC40_GL000179.
DR   PATRIC; fig|1423755.3.peg.192; -.
DR   UniPathway; UPA00537; UER00595.
DR   Proteomes; UP000051054; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009249; P:protein lipoylation; IEA:InterPro.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR019491; Lipoate_protein_ligase_C.
DR   InterPro; IPR004562; LipoylTrfase_LipoateP_Ligase.
DR   PANTHER; PTHR12561; PTHR12561; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF10437; Lip_prot_lig_C; 1.
DR   TIGRFAMs; TIGR00545; lipoyltrans; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00428641};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051054};
KW   Ligase {ECO:0000256|SAAS:SAAS00603725, ECO:0000313|EMBL:KRM19368.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00026749};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051054};
KW   Transferase {ECO:0000313|EMBL:KRM19368.1}.
FT   DOMAIN       29    220       BPL/LPL catalytic. {ECO:0000259|PROSITE:
FT                                PS51733}.
SQ   SEQUENCE   342 AA;  39178 MW;  A4D62941D675C41C CRC64;
     MEKMKYVIIP TDDIRTNLAT EQYLMNSGKI EPPFMLFYIE KPCIIVGRNQ NTMEEINQKY
     CEEHNITITR RLSGGGAMYQ DLGNMCFSFV VPSKDQKFGD FASLVKPVVD ALHEMGVTKA
     EVTGRNDIVV AGKKFSGNAM YSRNGKTFSH GTLMFDVDTS AVEGALKVPK DKIESKGIKS
     VRSRVTNIKQ YLKPEYQELD IYGFRDELIK HIYQVSDLNE IKDQQYQLDE EDIAAIEELA
     QKNYKNWDWV FGKSPEFTVK RRRHFTGGTI DARFKVDNGI IESLNIYGDF FGTGDKQEVE
     QALIGKKYEP DEIRKQLSEL DLKKYFVGID EADVVELLAF QQ
//
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