ID A0A0R2A858_9LACO Unreviewed; 572 AA.
AC A0A0R2A858;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN ORFNames=FC14_GL001122 {ECO:0000313|EMBL:KRM62885.1};
OS Ligilactobacillus agilis DSM 20509.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1423718 {ECO:0000313|EMBL:KRM62885.1, ECO:0000313|Proteomes:UP000051008};
RN [1] {ECO:0000313|EMBL:KRM62885.1, ECO:0000313|Proteomes:UP000051008}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20509 {ECO:0000313|EMBL:KRM62885.1,
RC ECO:0000313|Proteomes:UP000051008};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRM62885.1}.
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DR EMBL; AYYP01000072; KRM62885.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2A858; -.
DR PATRIC; fig|1423718.3.peg.1180; -.
DR Proteomes; UP000051008; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Reference proteome {ECO:0000313|Proteomes:UP000051008};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..9
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 29..572
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 133..192
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 572 AA; 65596 MW; EBD099834247686E CRC64;
MKDGIVMVAA LVAIVVLAVV IYLGALYFQR LNNARISAIE DITAKIEANS QEDELAAISK
LNLTGESLAA FEELDKSYRA LINRELPFLV ERLKDVKEAN QHFSFPTVKS DLETLEAKGA
AANMAFTKII KQIKQIKQQT DQHQQNIDSL QTKYQEIRKK LLAKNFSYGP AITRLEAALA
DLEKDFKEYE NIAENGDYVK ADKALAKLKD DTKTLEVALK QIPPIYQKLH NVYPDQLTDL
KDALAKMQEE KYLFKEDMTA KLADLDQQSQ ALTTALTKLD LETAKLLEKE LGHQIEAAYT
VFEEEYTARE KVEAKTKFYA DFIEHAEKQE RRLSLELDRL GQNYTLNNDE KARERQLAEQ
LKEIHAAYTS YQAALMTDGV IYSQILQQME QAFSDLKAIE EEQGRINDGV ANLWKEEKQA
WEAVNQFNLD LAKYRRDLEK LNLPGLQTEY LDYYYRVKDE VEAVYQSLDH VKIDMAAITK
DLIDTQADLD ALEEKTKDIV DSSSLTEEML QYSNRYRNRY PEVAQAYQQA KKLFSEDYDY
VAALDTIAQA VDKVEPGAYD KVSARYHKRQ QG
//