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Database: UniProt
Entry: A0A0R2A858_9LACO
LinkDB: A0A0R2A858_9LACO
Original site: A0A0R2A858_9LACO 
ID   A0A0R2A858_9LACO        Unreviewed;       572 AA.
AC   A0A0R2A858;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN   ORFNames=FC14_GL001122 {ECO:0000313|EMBL:KRM62885.1};
OS   Ligilactobacillus agilis DSM 20509.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Ligilactobacillus.
OX   NCBI_TaxID=1423718 {ECO:0000313|EMBL:KRM62885.1, ECO:0000313|Proteomes:UP000051008};
RN   [1] {ECO:0000313|EMBL:KRM62885.1, ECO:0000313|Proteomes:UP000051008}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20509 {ECO:0000313|EMBL:KRM62885.1,
RC   ECO:0000313|Proteomes:UP000051008};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC       nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00728}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRM62885.1}.
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DR   EMBL; AYYP01000072; KRM62885.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R2A858; -.
DR   PATRIC; fig|1423718.3.peg.1180; -.
DR   Proteomes; UP000051008; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW   Rule:MF_00728};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051008};
KW   Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_00728};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_00728}.
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT   TRANSMEM        6..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TOPO_DOM        29..572
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT   COILED          133..192
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   572 AA;  65596 MW;  EBD099834247686E CRC64;
     MKDGIVMVAA LVAIVVLAVV IYLGALYFQR LNNARISAIE DITAKIEANS QEDELAAISK
     LNLTGESLAA FEELDKSYRA LINRELPFLV ERLKDVKEAN QHFSFPTVKS DLETLEAKGA
     AANMAFTKII KQIKQIKQQT DQHQQNIDSL QTKYQEIRKK LLAKNFSYGP AITRLEAALA
     DLEKDFKEYE NIAENGDYVK ADKALAKLKD DTKTLEVALK QIPPIYQKLH NVYPDQLTDL
     KDALAKMQEE KYLFKEDMTA KLADLDQQSQ ALTTALTKLD LETAKLLEKE LGHQIEAAYT
     VFEEEYTARE KVEAKTKFYA DFIEHAEKQE RRLSLELDRL GQNYTLNNDE KARERQLAEQ
     LKEIHAAYTS YQAALMTDGV IYSQILQQME QAFSDLKAIE EEQGRINDGV ANLWKEEKQA
     WEAVNQFNLD LAKYRRDLEK LNLPGLQTEY LDYYYRVKDE VEAVYQSLDH VKIDMAAITK
     DLIDTQADLD ALEEKTKDIV DSSSLTEEML QYSNRYRNRY PEVAQAYQQA KKLFSEDYDY
     VAALDTIAQA VDKVEPGAYD KVSARYHKRQ QG
//
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