ID A0A0R2GAG7_9LACO Unreviewed; 704 AA.
AC A0A0R2GAG7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Pbp2B2 protein {ECO:0000313|EMBL:KRN33764.1};
GN ORFNames=IV38_GL000595 {ECO:0000313|EMBL:KRN29707.1}, IV40_GL000073
GN {ECO:0000313|EMBL:KRN33764.1};
OS Lactobacillus selangorensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=81857 {ECO:0000313|EMBL:KRN33764.1, ECO:0000313|Proteomes:UP000051645};
RN [1] {ECO:0000313|Proteomes:UP000051645, ECO:0000313|Proteomes:UP000051751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-66 {ECO:0000313|EMBL:KRN29707.1,
RC ECO:0000313|Proteomes:UP000051751}, and DSM 13344
RC {ECO:0000313|EMBL:KRN33764.1, ECO:0000313|Proteomes:UP000051645};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN33764.1}.
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DR EMBL; JQAT01000001; KRN29707.1; -; Genomic_DNA.
DR EMBL; JQAZ01000001; KRN33764.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2GAG7; -.
DR STRING; 81857.IV38_GL000595; -.
DR PATRIC; fig|81857.3.peg.600; -.
DR Proteomes; UP000051645; Unassembled WGS sequence.
DR Proteomes; UP000051751; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051645};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..310
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 357..688
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 704 AA; 75939 MW; 100C4448D3A31351 CRC64;
MRPIDSKEKP QKPNRAKSNI PFRLNLLFFI VFLLFAALVG QLAYLQIMYG SKFSSSVNST
DQTTVSGAVP RGMMYDTKGR VLVGNKAQSA ITYTKGADTL STQMYAVANK LGTYITVDTD
TLTPQDKADY YLADAHNLKT TNAKLPKSQK VDSSGSELAE KTVYKNQIAY VEAHHLDELT
ATQKNAAAIY KIMNGAYQMS TVYIKNSGLT SATLAKVSEH LTELPGVSVG TDWERSYPNG
EGITSIIGNV STEKQGLPSD QLTELLSDGY SRNDRVGTSY LEKEYQSILS GTKSQTEVKT
NSEGSVKSTK EVYAGKKGAS LNLTIDSKYQ NQVEAALKKE FKAAVSDGAA KYSDGAYAMA
MDPNTGAVLA IAGVKQNRKT GKITDNALGA INQTFVPGSA VKGATVMGAL MDGVITPTNN
TQSDDAIYLP GTAVKKSVYP VGTFTSLDAV TALEISSNIY MMRLAMKEGN AKYVADSSFS
IDHNIFATER GYFNQFGLGV KTGIDLPGEA SPYIGSTTNS DGSFKSGSAL DLSYGNYDAY
TVVELAQYVS TIANNGRRMQ PYVVKSVEST SNNGKKGQVE SVTMPKVMNT VNATKDEFNV
VHKGFYETIH GTNAWATATR LKSLSPSAAA KTGTAQTFAH TDPDNDNSKQ VETMNLSLVA
YAPYKNPKVA IALIFPNMTD EDGAYNTVLG KEMISDYYKD YNIK
//
