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Database: UniProt
Entry: A0A0R2I9H1_9LACO
LinkDB: A0A0R2I9H1_9LACO
Original site: A0A0R2I9H1_9LACO 
ID   A0A0R2I9H1_9LACO        Unreviewed;       420 AA.
AC   A0A0R2I9H1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-SEP-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=IV45_GL001014 {ECO:0000313|EMBL:KRN58564.1};
OS   Lactobacillus secaliphilus.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=396268 {ECO:0000313|EMBL:KRN58564.1, ECO:0000313|Proteomes:UP000050934};
RN   [1] {ECO:0000313|EMBL:KRN58564.1, ECO:0000313|Proteomes:UP000050934}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17896 {ECO:0000313|EMBL:KRN58564.1,
RC   ECO:0000313|Proteomes:UP000050934};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O.,
RA   Ritari J., Douillard F.P., Paul Ross R., Yang R., Briner A.E.,
RA   Felis G.E., de Vos W.M., Barrangou R., Klaenhammer T.R.,
RA   Caufield P.W., Cui Y., Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through
RT   comparative genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRN58564.1}.
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DR   EMBL; JQBW01000010; KRN58564.1; -; Genomic_DNA.
DR   EnsemblBacteria; KRN58564; KRN58564; IV45_GL001014.
DR   PATRIC; fig|396268.3.peg.1026; -.
DR   Proteomes; UP000050934; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050934};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050934}.
FT   DOMAIN      116    245       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      328    397       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     124    131       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   420 AA;  47527 MW;  4DF4B3D03AEDD5AA CRC64;
     MTYDNVVAPA KAYSLSNGRL TVVVPTDYHL DFWQNKLDVQ LKHILKEETG QDIDTRYVLT
     KDLIGAKPTD NVKKEPTFKE TTPLNPEYTF ETFVEGRSNQ FAYASAYGAS EQPGLLYNPL
     LIYGGVGLGK THLMQAIANA MLQRNPNAKI KYVTSENFVN DYINSIKTGT QEQFRQAYRD
     LDALLVDDVQ FLSSKNETQL EFFNTFNVLH DNNKQIVLTA DQNPKEIPNL TERLVSRFVW
     GLTVEITPPD LETRIAILNR KADEEHIENV PNEVFNFIAS KINTNVRELE GALMRVRVFA
     QLHSQPMSLS VAKEALQGIG EDASTELNID LIQKKVAAYF NINQSDITGK KRVKNIVVPR
     QIAMYLSREL TDNSLPRIGR AFGGKDHTTV LHAIDKIEKQ IGQDTQLKNT VDKLQNDLRP
//
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