ID A0A0R2JSH9_9LACO Unreviewed; 554 AA.
AC A0A0R2JSH9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=RND superfamily drug exporter {ECO:0000313|EMBL:KRN80064.1};
GN ORFNames=IV52_GL000182 {ECO:0000313|EMBL:KRN80064.1};
OS Fructilactobacillus lindneri DSM 20690 = JCM 11027.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Fructilactobacillus.
OX NCBI_TaxID=1122148 {ECO:0000313|EMBL:KRN80064.1, ECO:0000313|Proteomes:UP000051565};
RN [1] {ECO:0000313|EMBL:KRN80064.1, ECO:0000313|Proteomes:UP000051565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20690 {ECO:0000313|EMBL:KRN80064.1,
RC ECO:0000313|Proteomes:UP000051565};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN80064.1}.
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DR EMBL; JQBT01000012; KRN80064.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2JSH9; -.
DR STRING; 53444.AYR59_00950; -.
DR PATRIC; fig|1122148.6.peg.191; -.
DR Proteomes; UP000051565; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051565};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 148..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..239
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT COILED 48..75
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 554 AA; 62916 MW; 5740262539D7F739 CRC64;
MPNLTHLVET QNIPFNLPAK QVKINWGNHL DHARPLTVVY SNHNHRLSQH NNKQIDSIER
KIQEHKQELG ILKLVSTKTS PYSHHVFSSS DKKVLLLELW VPKNKLQHPN FINKIQHQCN
INGLETHITS PELINHSIAE NTIQKSKVAV LTTFCFALIF FLIVFKSILL PILSIIPLGI
SYIVSLSIIA NLSQRQIIPF SANIPLLVAL TVLLLGTVTT FLIYHRLTVS LTNNLGRKKR
RKYALAALII PLILIVSVIS LAFLSFHWFD FLPIKALSNL IIPILITTIA TISLNSIFIK
IFQTKLFWPG KPQNKIFTGP IWQRLVKFSL WQPLAGIILL SLISFPLLTK SHFKFNFSNY
QIAEKKLIQG QRIIQSHFNF GKSTPVTIYL KNNHKLTNEH DLAVIDHLTT KLQTMKNVAS
VQSVTQPGGT KVKKYYLQSQ LAKFSHSLNR SNQELKLVRQ SLHKINQAEL NKNTINSQQN
ELTQLSQSIN ATLQLSQQES LTTDDANQIN FLAVNLGRLN QLNQNGATVS DQFTQYTQTL
KALNDNLQTI SEKL
//
