ID A0A0R2KIM3_9LACO Unreviewed; 547 AA.
AC A0A0R2KIM3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=proton-translocating NAD(P)(+) transhydrogenase {ECO:0000256|ARBA:ARBA00012943};
DE EC=7.1.1.1 {ECO:0000256|ARBA:ARBA00012943};
GN ORFNames=IV53_GL000161 {ECO:0000313|EMBL:KRN89248.1};
OS Ligilactobacillus ceti DSM 22408.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1122146 {ECO:0000313|EMBL:KRN89248.1, ECO:0000313|Proteomes:UP000051500};
RN [1] {ECO:0000313|EMBL:KRN89248.1, ECO:0000313|Proteomes:UP000051500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22408 {ECO:0000313|EMBL:KRN89248.1,
RC ECO:0000313|Proteomes:UP000051500};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+);
CC Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000006};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN89248.1}.
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DR EMBL; JQBZ01000017; KRN89248.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2KIM3; -.
DR STRING; 1122146.IV53_GL000161; -.
DR PATRIC; fig|1122146.4.peg.163; -.
DR eggNOG; COG1282; Bacteria.
DR Proteomes; UP000051500; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 3.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR034300; PNTB-like.
DR PANTHER; PTHR44758; NAD(P) TRANSHYDROGENASE SUBUNIT BETA; 1.
DR PANTHER; PTHR44758:SF1; NAD(P) TRANSHYDROGENASE SUBUNIT BETA; 1.
DR Pfam; PF02233; PNTB; 3.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000051500};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 15..187
FT /note="NADP transhydrogenase beta-like"
FT /evidence="ECO:0000259|Pfam:PF02233"
FT DOMAIN 194..364
FT /note="NADP transhydrogenase beta-like"
FT /evidence="ECO:0000259|Pfam:PF02233"
FT DOMAIN 372..545
FT /note="NADP transhydrogenase beta-like"
FT /evidence="ECO:0000259|Pfam:PF02233"
SQ SEQUENCE 547 AA; 59127 MW; 93F73A9B0CBC8FF0 CRC64;
MNKLVTNLIQ APKASHVATS VEENNHINVL RNAKKVIIVP GYGMALSQAQ QAVATLAQKL
KDQGTEVKYA IHPVAGRMPG HMSVLLCEAD VDYSELYMME DINDDFKDAD AVIVVGANDV
TNPSANTAEG TPIYGMPILN VEDAQNIIIC NFDTKPGYAG VDNPLYTSEK TTMLLGDAKE
TVNKLITDLA QVPQTTEDSE NNPVQVLRDA KKVIIVPGYG MALSQAQQAV ATLAQKLKDQ
GSEVKYAIHP VAGRMPGHMS VLLCEADVDY SELYMMEDIN DDFKDADVVI VVGANDVTNP
SANTAEGTPI YGMPILNVED AQNIIICNFD TKPGYAGVDN PLYTFEKTTM LLGDAKETVN
KLITDLAQAP QTAEKTTEDV VKDPIKVLHD AKKVIVVPGY GMALSQAQQS VANLAQKLKD
QGTEVKYAIH PVAGRMPGHM SVLLCEANID YSELYMMEDI NEDFKDVDAV IVVGANDVTN
PAANTAEGTP IYGMPILNVE DAPQIIICNF DTKPGYAGVD NPLYTLDKTI MLLGDAKETV
DKLIADF
//
