ID A0A0R2KQ99_9LACO Unreviewed; 683 AA.
AC A0A0R2KQ99;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:KRN88567.1};
GN ORFNames=IV53_GL000532 {ECO:0000313|EMBL:KRN88567.1};
OS Ligilactobacillus ceti DSM 22408.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1122146 {ECO:0000313|EMBL:KRN88567.1, ECO:0000313|Proteomes:UP000051500};
RN [1] {ECO:0000313|EMBL:KRN88567.1, ECO:0000313|Proteomes:UP000051500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22408 {ECO:0000313|EMBL:KRN88567.1,
RC ECO:0000313|Proteomes:UP000051500};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN88567.1}.
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DR EMBL; JQBZ01000025; KRN88567.1; -; Genomic_DNA.
DR RefSeq; WP_027106976.1; NZ_KE383993.1.
DR AlphaFoldDB; A0A0R2KQ99; -.
DR STRING; 1122146.IV53_GL000532; -.
DR PATRIC; fig|1122146.4.peg.547; -.
DR eggNOG; COG0768; Bacteria.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000051500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051500};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..301
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 344..655
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 683 AA; 74503 MW; DF5B7817E45C341F CRC64;
MKFIKKRNKS EHQPKSQLPL RLNILFVIVF ILFAMLIGQL ANLQIINGPK FEAEATNNDV
LTSRKNVPRG MIYDATGKLL AANNSSRAIT YTKPLIVSHK EMYQLANNLV KYIKVDTTNI
SQSNKVDYYL AQPGKEEKVN KHIKQAATLD GSVLYAKQFD YITKHKLYKK FTTAQKEAAV
IYGRMNAAYS LSTVYLKTSD VSDDEMAEVG GHLASLPGVK IGTSWSRSYP EGEAIKSVIG
TVTSEKQGLP STHVNSLLAQ GYSRNDSVGS SYIESEYEDA LKGTKEIVNL ETKNGQITKE
IKKYGGQPGD NIVLTINAKF QTKVQSIIES ALKNSGNPYA PGAYAIVMNP NNGAILALAG
VSRDIKTGKV TENAIGTINR AFVMGSVVKP AMIMGGFHSG VITPRHNTLV DKPIKIAGTP
PKGSWFNHHG NNDMPLTASD ALMVSSNSYM MQLAMKEAHF HYRPGKDLTM NPDIFNKLRS
NFNQFGLGVK TGVDIPGEGT GFEGPGGTAN IGKALDLSFG NYDSYTPIQL AQYISVLANG
GYRLQPHIVQ SIRGTNANGS LGPIKHVFEP NILNVVPGTT AEWNIIKNGL YKVVHSSSRY
RTGSTMASVK PLLVGKTGTA QTFYKNNNTF TLSAITYAPQ KNPQVAVAVV FPGVSHERPI
HMQSTNAIYQ AYWSMVQSSE GLE
//
