ID A0A0R2LJD7_9LACO Unreviewed; 654 AA.
AC A0A0R2LJD7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Translation elongation factor (GTPase) {ECO:0000313|EMBL:KRO01654.1};
GN ORFNames=IV66_GL002170 {ECO:0000313|EMBL:KRO01654.1};
OS Ligilactobacillus pobuzihii.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=449659 {ECO:0000313|EMBL:KRO01654.1, ECO:0000313|Proteomes:UP000051886};
RN [1] {ECO:0000313|EMBL:KRO01654.1, ECO:0000313|Proteomes:UP000051886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 103219 {ECO:0000313|EMBL:KRO01654.1,
RC ECO:0000313|Proteomes:UP000051886};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRO01654.1}.
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DR EMBL; JQCN01000007; KRO01654.1; -; Genomic_DNA.
DR RefSeq; WP_017867189.1; NZ_JQCN01000007.1.
DR AlphaFoldDB; A0A0R2LJD7; -.
DR STRING; 449659.IV66_GL002170; -.
DR PATRIC; fig|449659.4.peg.2231; -.
DR OrthoDB; 9801591at2; -.
DR Proteomes; UP000051886; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Elongation factor {ECO:0000313|EMBL:KRO01654.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:KRO01654.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051886}.
FT DOMAIN 1..237
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 654 AA; 72668 MW; 6A93A525059C603F CRC64;
MKQIVTGIVA HVDAGKTTLS EALLYQTGSL RQLGRVDDQN TFLDPEKLEK QRGITIFSHQ
ARLISNDLEL TLLDTPGHVD FAAQTEQVLS VLDYAVLVVS ASSGIQGYTL ILWRLLARYH
VPVFIFVNKM DTTERNRQQI IEQLQKEFSP GCLDFTKAFA QKGDFNQLND EFCESVALCD
ADVLDGYLEN SELSAETIQQ MIIERQVFPC YFGSALKMTG TAELLLGMEY WTKQPPVVNQ
PFGALVFKVS HSKNDERLTW VRLTSGSLHP KEILLGEQKV NQLRIYNGSK YEVLPEVTCG
QVCAIPGLKE TYPSQGLGSQ KDAVQPQLTP VLTYVVDKKG QDVQVCLKAL RQLQDEDPQL
HVTWSEELKE IQVQLMGEIQ IEVLTNILME RFGLDLGFDQ GSILYKESIK SPVEGVGHFE
PLRHYAEVHL RLEPAPAGSG LTFASECSLE VLASNWQHQV LSNLQAKQHL GVLLGVPLTD
MKITLVSGKA SNVHTVGGDF REATWRAVRQ GLMELRQQDQ CVLLEPWYRF NLQVGSEQVG
RAMTDIERMS GQFKIPGNSA ENSGLVTLTG QAPVSEMQDY AAKVRAYTHG KGQLECVFAG
YFPCHNTTEV VAQQGYDPGS DLNNTPGSIF CAHGAGYPVA WNKVPEMAHV GYSN
//
