ID A0A0R2Q5W2_9ACTN Unreviewed; 299 AA.
AC A0A0R2Q5W2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=isocitrate dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00013013};
DE EC=1.1.1.42 {ECO:0000256|ARBA:ARBA00013013};
DE Flags: Fragment;
GN ORFNames=ABR70_00760 {ECO:0000313|EMBL:KRO45656.1};
OS Actinobacteria bacterium BACL4 MAG-120813-bin39.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1655578 {ECO:0000313|EMBL:KRO45656.1, ECO:0000313|Proteomes:UP000053569};
RN [1] {ECO:0000313|EMBL:KRO45656.1, ECO:0000313|Proteomes:UP000053569}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BACL4 MAG-120813-bin39 {ECO:0000313|EMBL:KRO45656.1};
RA Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA Andersson A.F.;
RT "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRO45656.1}.
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DR EMBL; LIBC01000080; KRO45656.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2Q5W2; -.
DR Proteomes; UP000053569; Unassembled WGS sequence.
DR GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR004790; Isocitrate_DH_NADP.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR NCBIfam; TIGR00127; nadp_idh_euk; 1.
DR PANTHER; PTHR11822:SF21; ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL; 1.
DR PANTHER; PTHR11822; NADP-SPECIFIC ISOCITRATE DEHYDROGENASE; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KRO45656.1}.
FT DOMAIN 9..299
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
FT NON_TER 299
FT /evidence="ECO:0000313|EMBL:KRO45656.1"
SQ SEQUENCE 299 AA; 34045 MW; 838A58BB766113B3 CRC64;
MNKIKVEGTV VELDGDEMTR IIWQFIKDSL ILPYLDINLE YYDLGVEYRD KTDDQVTIDS
AHAIQKHGVG VKCATITPDE ARVKEFNLKK MWKSPNGTIR NILGGVIFRE PIIIKNVPRL
IPHWNKPIVI GRHAFGDQYR ATDFKVPGAG KLTMTFTPQD GSKPMEFNVF DFPSSGVAMA
MYNLDDSIRD FARASFNYGL IRKYPVFLST KNTILKAYDG RFKDIFAEVF EKEFKAEFDK
NNLEYDHRLI DDMVATSLRW EGGYIWACKN YDGDVQSDTV AQGYGSLGLM TSVLMTPDG
//
