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Database: UniProt
Entry: A0A0R2SFZ3_9ACTN
LinkDB: A0A0R2SFZ3_9ACTN
Original site: A0A0R2SFZ3_9ACTN 
ID   A0A0R2SFZ3_9ACTN        Unreviewed;       476 AA.
AC   A0A0R2SFZ3;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ABS00_06510 {ECO:0000313|EMBL:KRO73733.1};
OS   Actinobacteria bacterium BACL2 MAG-120920-bin34.
OC   Bacteria; Actinobacteria.
OX   NCBI_TaxID=1655602 {ECO:0000313|EMBL:KRO73733.1, ECO:0000313|Proteomes:UP000051188};
RN   [1] {ECO:0000313|EMBL:KRO73733.1, ECO:0000313|Proteomes:UP000051188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BACL20 MAG-120920-bin34 {ECO:0000313|EMBL:KRO73733.1};
RA   Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C.,
RA   Pinhassi J., Andersson A.;
RT   "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRO73733.1}.
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DR   EMBL; LIBS01000102; KRO73733.1; -; Genomic_DNA.
DR   Proteomes; UP000051188; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051188};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895}.
FT   DOMAIN      168    296       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      380    449       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     176    183       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   476 AA;  53147 MW;  4EABFDBB95AC271A CRC64;
     MSIAEPGALE AKEIEADLLE LWKGIVDSVA KESPQNRAFL TLTKPLGLLK SDGGSNLLLA
     APNVFAKDVL ESRLKVLLND ALSAKLGERI NIAVTVDESL DADLSVVEEV DVEVESPRAG
     TGRQEVQSKS SDQTQLNPRY IFETFVIGAS NRFAHAAAVA VAEAPAKAYN PLFIYGESGL
     GKTHLLQAIG AYAKELYGGV RVRYVSSEEF TNDFINSIRD DKSSNFQRRY RDLDVLLVDD
     IQFLENKERT QEEFFHTFNT LYNANKQIVI SSDRPPKQLT TLEDRLRSRF EWGLITDIQP
     PELETRIAIL RKKAAQDKLN APDDVLEYIA SKISTNIREL EGALIRVTAF ASLNRQIVDM
     NLAEIVLKDL IPDDSTPEIT ASLIMAQTAS YFSLTLDDLC GTSRSRVLVN ARQIAMYLCR
     EMTELSLPKI GQTFGGRDHT TVMHADRKVR HLMAERRSIF NQVSELTNRI KLQAKA
//
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